LIDOCAINE HCL 2% w/v MULTIDOSE (20mg/ml) [Gulf Inject] Injection/Solution for

What is LIDOCAINE HCL 2% w/v MULTIDOSE (20mg/ml) [Gulf Inject]

LIDOCAINE HCL 2% w/v MULTIDOSE (20 mg/mL) [Gulf Inject] is an injectable solution containing Lidocaine Hydrochloride, a commonly used local anesthetic. It is formulated to provide a 2% concentration of Lidocaine, which is equivalent to 20 mg/mL, and is presented in a 100 mL LDPE (Low-Density Polyethylene) ampoule for multi-dose use. This formulation is intended to be used for local anesthesia in various medical procedures requiring pain relief.

• Concentration: 2% w/v (20 mg/mL)
• Total Lidocaine Content: 2000 mg per 100 mL ampoule
• Common Uses: Local anesthesia for minor surgeries, dental procedures, nerve blocks, and emergency arrhythmia management.
• Pharmacological Class: Local anesthetic (amide-type) and antiarrhythmic agent.

The multi-dose feature allows multiple administrations from a single ampoule, which is especially useful in clinical settings where multiple doses are required for different patients or procedures.

How to use LIDOCAINE HCL 2% w/v MULTIDOSE (20mg/ml) [Gulf Inject]

LIDOCAINE HCL 2% w/v MULTIDOSE solution is administered via injection by healthcare professionals. It is essential to adhere to proper dosing and injection techniques to ensure safety and effectiveness.

• Infiltration Anesthesia: Typically, 5–10 mL (100–200 mg) is sufficient to anesthetize the desired area.
• Nerve Block: The amount required for nerve blocks can vary depending on the procedure, but typically 3–5 mL per nerve is used.
• Maximum Dose: For an adult patient, the maximum recommended dose should not exceed 4.5 mg/kg of body weight, which is generally equivalent to a total dose of 300 mg.
• Multi-Dose Use: This product is suitable for multiple doses from a single ampoule. Discard any unused solution after administration to avoid contamination.

It is important to monitor the patient for any adverse reactions during and after administration, particularly if the total dosage is approaching the maximum safe limits.

Mode of Action LIDOCAINE HCL 2% w/v MULTIDOSE (20mg/ml) [Gulf Inject]

Lidocaine works by blocking sodium channels in nerve membranes, which inhibits the generation and conduction of nerve impulses. This prevents the transmission of pain signals to the brain, resulting in local numbness in the area where it is applied. The action of Lidocaine is reversible, meaning that once the drug is metabolized and eliminated, normal nerve function is restored.

• Local Anesthesia: Lidocaine temporarily numbs the area where it is administered, making it useful for a wide variety of minor medical procedures.
• Antiarrhythmic Effect: Lidocaine also has antiarrhythmic properties, stabilizing the electrical activity of the heart and preventing abnormal heart rhythms.
• Duration of Action: The anesthetic effects typically last between 30 minutes and 2 hours, depending on the dosage, procedure, and site of injection.

LIDOCAINE HCL 2% w/v MULTIDOSE (20mg/ml) [Gulf Inject] Interactions LIDOCAINE HCL 2% w/v MULTIDOSE (20mg/ml) [Gulf Inject]

Lidocaine can interact with various drugs, and these interactions can alter its effects, sometimes leading to adverse outcomes. Here are some key drug interactions to be aware of:

• Beta-Blockers (e.g., propranolol): These may increase the plasma levels of Lidocaine, raising the risk of toxicity.
• CYP3A4 Inhibitors (e.g., ketoconazole, erythromycin): These drugs can slow the metabolism of Lidocaine, potentially leading to increased serum concentrations and heightened risk of side effects.
• Amiodarone: Can increase Lidocaine levels in the blood, which may lead to cardiac toxicity, especially in patients with heart arrhythmias.
• Phenytoin: Lidocaine may have a reduced effect when used with phenytoin, as both drugs are metabolized through similar liver enzymes.
• Other Local Anesthetics: Using multiple local anesthetics together may cause additive toxicity, especially to the central nervous system (CNS) and heart.

Consult a healthcare provider about all medications you are currently taking, including over-the-counter drugs and supplements, to avoid potential interactions with Lidocaine.

Dosage of LIDOCAINE HCL 2% w/v MULTIDOSE (20mg/ml) [Gulf Inject]

The appropriate dose of Lidocaine depends on the medical procedure being performed and the individual patient's characteristics. Below is a typical guideline for the use of LIDOCAINE HCL 2% w/v MULTIDOSE:

• Infiltration Anesthesia: Typically 5–10 mL (100–200 mg), depending on the size of the area requiring anesthesia.
• Nerve Block: Usually, 3–5 mL per nerve is adequate for most nerve block procedures.
• Maximum Dosage: The maximum recommended dose is generally 4.5 mg/kg body weight, or up to 300 mg for an average adult. Dosing may need adjustment based on patient weight or health status.

It is important to monitor for signs of overdose or toxicity, especially in patients with compromised liver or kidney function.

Possible side effects of LIDOCAINE HCL 2% w/v MULTIDOSE (20mg/ml) [Gulf Inject]

While Lidocaine is generally well-tolerated when used appropriately, side effects can occur, especially if the medication is administered in excess. Some of the possible side effects include:

• CNS Reactions: Dizziness, drowsiness, blurred vision, or in severe cases, seizures or loss of consciousness.
• Cardiovascular Effects: Hypotension (low blood pressure), bradycardia (slow heart rate), or arrhythmias, particularly at high doses or when administered too quickly.
• Injection Site Reactions: Pain, swelling, or redness at the site of injection.
• Allergic Reactions: In rare cases, Lidocaine can cause allergic reactions such as rash, itching, or more severe reactions like anaphylaxis.

If you experience any severe symptoms or signs of an allergic reaction, seek medical attention immediately.

LIDOCAINE HCL 2% w/v MULTIDOSE (20mg/ml) [Gulf Inject] Contraindications LIDOCAINE HCL 2% w/v MULTIDOSE (20mg/ml) [Gulf Inject]

Lidocaine should not be used in the following circumstances:

• Allergy or Hypersensitivity: A known allergy to Lidocaine or any other amide-type local anesthetics.
• Severe Heart Conditions: Patients with significant heart block (without a pacemaker), severe bradycardia, or untreated arrhythmias.
• Liver Dysfunction: Severe liver disease may impair the metabolism of Lidocaine, increasing the risk of toxicity.
• Infected Sites: Lidocaine should not be administered to areas with active infections, as this may complicate the procedure.
• Acute Porphyria: A condition that may be aggravated by the use of Lidocaine.

Always consult a healthcare provider before using Lidocaine to ensure that it is safe and appropriate based on individual health conditions.

Storage of LIDOCAINE HCL 2% w/v MULTIDOSE (20mg/ml) [Gulf Inject]

• Storage Temperature: Store at room temperature (15°C to 30°C / 59°F to 86°F). Do not refrigerate or freeze.
• Protection from Light: Keep the ampoule protected from direct sunlight and excessive light exposure.
• Keep Out of Reach of Children: Ensure that the product is stored safely, out of the reach of children and unauthorized personnel.
• Discard Unused Portion: Discard any unused solution after a single administration. Do not reuse ampoules or share between patients.

Ensure that the solution remains clear and free from visible particles. If the solution appears discolored or contains particles, it should be discarded.