LIDOCAINE HCL 2% w/v MULTIDOSE (20mg/ml) [Gulf Inject] Injection/Solution for

What is LIDOCAINE HCL 2% w/v MULTIDOSE (20mg/ml) [Gulf Inject]

LIDOCAINE HCL 2% w/v MULTIDOSE (20 mg/mL) [Gulf Inject] is a multi-dose injectable solution of Lidocaine Hydrochloride, a commonly used local anesthetic. It is formulated to contain 2% Lidocaine, or 20 mg/mL, and is packaged in a 50 mL LDPE (Low-Density Polyethylene) ampoule. This solution is designed for use in medical procedures that require local anesthesia or regional nerve block, providing temporary pain relief during surgeries or diagnostic procedures.

• Concentration: 2% w/v (20 mg/mL)
• Total Lidocaine Content: 1000 mg per 50 mL ampoule
• Common Uses: Infiltration anesthesia, nerve block procedures, and emergency arrhythmia management (as an antiarrhythmic agent).
• Pharmacological Class: Local anesthetic (amide-type) and antiarrhythmic.

This formulation is for use by healthcare professionals in controlled environments such as hospitals or clinics.

How to use LIDOCAINE HCL 2% w/v MULTIDOSE (20mg/ml) [Gulf Inject]

The LIDOCAINE HCL 2% w/v MULTIDOSE solution is intended for parenteral (injection) use. It is essential to follow the correct dosage and administration procedures based on the type of procedure being performed and the patient's condition.

• Infiltration Anesthesia: 5–10 mL (100–200 mg) depending on the size of the area being anesthetized.
• Nerve Block: 3–5 mL per nerve for most block procedures.
• Maximum Dose: The total dose should not exceed 4.5 mg/kg body weight. For an adult, the maximum dose is typically 300 mg per administration.
• Multi-Dose Use: This product is designed for multi-dose use, meaning multiple procedures can be completed from one ampoule. However, any unused solution should be discarded after the procedure.

Ensure that the injection is administered by trained healthcare personnel who can manage any potential side effects and adverse reactions.

Mode of Action LIDOCAINE HCL 2% w/v MULTIDOSE (20mg/ml) [Gulf Inject]

Lidocaine exerts its effects by inhibiting sodium ion channels in nerve membranes. This prevents the depolarization of nerve cells, effectively blocking the transmission of pain signals to the brain. The action of Lidocaine is reversible, meaning once the drug is metabolized and eliminated from the body, normal nerve function is restored.

• Local Anesthesia: Provides localized numbing at the injection site, allowing for pain-free procedures.
• Antiarrhythmic Action: By stabilizing cardiac cell membranes, Lidocaine can help prevent abnormal heart rhythms (arrhythmias), especially during medical emergencies.
• Duration of Effect: The anesthetic effect typically lasts from 30 minutes to 2 hours, depending on the procedure and site of injection.

LIDOCAINE HCL 2% w/v MULTIDOSE (20mg/ml) [Gulf Inject] Interactions LIDOCAINE HCL 2% w/v MULTIDOSE (20mg/ml) [Gulf Inject]

Lidocaine can interact with various medications, which may enhance its effects or lead to undesirable side effects. Some key interactions to consider include:

• Beta-Blockers (e.g., propranolol): These can increase Lidocaine plasma levels, raising the risk of toxicity.
• CYP3A4 Inhibitors (e.g., ketoconazole, erythromycin): These drugs can slow Lidocaine metabolism, leading to elevated blood levels and possible adverse effects.
• Amiodarone: Amiodarone may increase Lidocaine levels, increasing the risk of cardiac toxicity, especially in patients with arrhythmias.
• Phenytoin: Co-administration may lower the efficacy of Lidocaine, as both drugs share metabolic pathways.
• Other Local Anesthetics: Concurrent use with other local anesthetics may lead to an additive toxic effect, particularly on the central nervous system and heart.

Always inform your healthcare provider about any medications you are currently taking to avoid potential interactions with Lidocaine.

Dosage of LIDOCAINE HCL 2% w/v MULTIDOSE (20mg/ml) [Gulf Inject]

The proper dosage of Lidocaine depends on the medical procedure being performed and the patient's health condition. As a guideline, the following doses are typically used:

• Infiltration Anesthesia: Typically, 5–10 mL (100–200 mg) is sufficient for most minor surgical procedures.
• Nerve Block: Usually, 3–5 mL per nerve is adequate for most block techniques.
• Maximum Dosage: The total dose should not exceed 4.5 mg/kg body weight. The maximum adult dose is generally considered to be 300 mg per administration.

Adjustments may be necessary based on the patient's weight, medical history, or underlying conditions, such as liver or kidney impairment.

Possible side effects of LIDOCAINE HCL 2% w/v MULTIDOSE (20mg/ml) [Gulf Inject]

While Lidocaine is generally safe when used correctly, it can cause side effects, especially if overdosed or improperly administered. Some common side effects include:

• Injection Site Reactions: Mild irritation, redness, or swelling.
• CNS Effects: Symptoms like dizziness, confusion, lightheadedness, or in severe cases, seizures.
• Cardiovascular Effects: Bradycardia (slow heart rate), hypotension (low blood pressure), or arrhythmias, particularly in high doses.
• Allergic Reactions: In rare cases, Lidocaine can cause allergic reactions such as rash, itching, or even anaphylaxis.

If any of these severe reactions occur, immediate medical attention is necessary.

LIDOCAINE HCL 2% w/v MULTIDOSE (20mg/ml) [Gulf Inject] Contraindications LIDOCAINE HCL 2% w/v MULTIDOSE (20mg/ml) [Gulf Inject]

Lidocaine should not be used in certain patients, including those with the following conditions:

• Known hypersensitivity or allergy to Lidocaine or other amide-type local anesthetics.
• Severe heart block (without a pacemaker).
• Acute porphyria (a rare metabolic disorder).
• Severe liver dysfunction, which may hinder the metabolism of Lidocaine.
• Infected areas at the intended injection site.

A careful medical history review and physical examination should be conducted before administering Lidocaine to ensure safety.

Storage of LIDOCAINE HCL 2% w/v MULTIDOSE (20mg/ml) [Gulf Inject]

• Store the product at room temperature (15°C to 30°C / 59°F to 86°F).
• Protect from light and do not freeze the solution.
• Keep the ampoules tightly sealed and out of reach of children.
• Discard any unused portion after administration—do not reuse.

Ensure the solution is clear and free from particles before use. If the solution appears discolored or contains visible particles, discard the ampoule.