LIDOCAINE HCL 2% W/V INJECTION (20mg/ml) [Gulf Inject] Injection/Solution for

What is LIDOCAINE HCL 2% W/V INJECTION (20mg/ml) [Gulf Inject]

LIDOCAINE HCL 2% w/v INJECTION (20 mg/mL) [Gulf Inject] is a sterile solution for local anesthesia and other medical uses, containing 2% Lidocaine Hydrochloride, equating to 20 mg of Lidocaine per 1 mL of solution. This medication is packaged in 10 mL LDPE ampoules, making it suitable for injection in a medical setting. It is used for various procedures requiring localized pain relief or nerve blockage.

• Concentration: 2% w/v (20 mg/mL)
• Total Lidocaine Content: 200 mg per 10 mL ampoule
• Pharmacological Class: Local anesthetic (amide-type)
• Common Uses: Local anesthesia for dental procedures, minor surgeries, or nerve blocks.

This solution is intended for use in clinical settings and should only be administered by trained healthcare professionals.

How to use LIDOCAINE HCL 2% W/V INJECTION (20mg/ml) [Gulf Inject]

Lidocaine HCL 2% w/v is designed for parenteral (injection) administration. Here are the general guidelines for its use:

• Infiltration Anesthesia: The typical dosage is 5–10 mL (100–200 mg) depending on the area and type of procedure being performed.
• Nerve Block: Typically, 3–5 mL of Lidocaine per nerve is effective for most local nerve blocks.
• Maximum Dosage: The total dose should not exceed 4.5 mg/kg body weight, with a maximum of 300 mg for an adult. This may vary based on the procedure and patient condition.
• Single-Use: Each ampoule is intended for single-use only. Discard any remaining solution after administration.

Ensure that a qualified healthcare professional administers the injection, and follow proper aseptic techniques to minimize the risk of infection.

Mode of Action LIDOCAINE HCL 2% W/V INJECTION (20mg/ml) [Gulf Inject]

Lidocaine works by blocking sodium ion influx through voltage-gated sodium channels in nerves, inhibiting the transmission of nerve impulses. This prevents the sensation of pain in the injected area, causing localized numbness. Additionally, Lidocaine has antiarrhythmic properties, which can stabilize abnormal heart rhythms.

• Local Anesthesia: Lidocaine blocks pain signals, leading to a temporary loss of sensation in the targeted area.
• Antiarrhythmic Effects: In the cardiovascular system, Lidocaine restores normal rhythm and suppresses abnormal electrical impulses in the heart.
• Rapid Onset: The anesthetic effect is typically rapid, with action occurring within minutes of injection.
• Duration of Action: The local anesthesia effect typically lasts between 30 minutes and 2 hours, depending on dosage and application method.

LIDOCAINE HCL 2% W/V INJECTION (20mg/ml) [Gulf Inject] Interactions LIDOCAINE HCL 2% W/V INJECTION (20mg/ml) [Gulf Inject]

Certain drugs can interact with Lidocaine, either enhancing its effects or causing side effects. Below are some notable interactions:

• Beta-blockers (e.g., propranolol): These can increase plasma levels of Lidocaine, potentially leading to toxicity.
• Amiodarone: The combination may increase the concentration of Lidocaine, heightening the risk of side effects such as cardiac arrhythmias.
• CYP3A4 Inhibitors (e.g., ketoconazole, erythromycin): These medications may slow down the metabolism of Lidocaine, leading to higher blood levels and potential toxicity.
• Rifampin and Phenytoin: These can accelerate the breakdown of Lidocaine, reducing its effectiveness.
• Other Local Anesthetics: Using multiple local anesthetics simultaneously can increase the risk of systemic toxicity.

Always consult a healthcare professional before combining Lidocaine with other medications to avoid adverse effects or interactions.

Dosage of LIDOCAINE HCL 2% W/V INJECTION (20mg/ml) [Gulf Inject]

The dosage of Lidocaine is determined based on the type of procedure and patient characteristics. Here are common dosing recommendations:

• Infiltration Anesthesia: Typical doses range from 5–10 mL (100–200 mg) depending on the procedure.
• Nerve Block: Usually, 3–5 mL per nerve for adequate pain control.
• Maximum Dose: The upper limit for an adult is generally 4.5 mg/kg body weight (up to 300 mg in most cases), though this can vary for specific patients or procedures.

Dosing should always be tailored to the patient's needs and carefully adjusted to avoid toxicity.

Possible side effects of LIDOCAINE HCL 2% W/V INJECTION (20mg/ml) [Gulf Inject]

Lidocaine is generally safe when used appropriately, but improper dosing or administration can lead to side effects. Common side effects may include:

• Injection Site Reactions: Pain, redness, or swelling at the injection site.
• CNS Symptoms: Dizziness, confusion, or, in rare cases, seizures if excessive amounts are administered.
• Cardiovascular Effects: Bradycardia (slow heart rate), hypotension, or arrhythmias, especially if too much Lidocaine is administered.
• Allergic Reactions: Rash, itching, or severe reactions like anaphylaxis, though rare.

Any signs of severe reactions, especially affecting the heart or nervous system, require immediate medical attention.

LIDOCAINE HCL 2% W/V INJECTION (20mg/ml) [Gulf Inject] Contraindications LIDOCAINE HCL 2% W/V INJECTION (20mg/ml) [Gulf Inject]

• Known hypersensitivity to Lidocaine or other amide-type local anesthetics.
• Severe heart block without a functioning pacemaker.
• Severe liver dysfunction.
• Porphyria (a rare metabolic disorder).
• Active infections at the site of injection.

Patients with any of these conditions should not use Lidocaine without proper medical consultation.

Storage of LIDOCAINE HCL 2% W/V INJECTION (20mg/ml) [Gulf Inject]

• Store at room temperature (15°C to 30°C / 59°F to 86°F).
• Protect from light and do not freeze.
• Discard any unused portion immediately after administration.
• Keep the medication out of reach of children.

Ensure that the ampoule is intact and that the solution is clear before use. Do not use if the solution is discolored or contains particles.