LIDOCAINE HCL 2% W/V INJECTION (20mg/ml) [Gulf Inject] Injection/Solution for

What is LIDOCAINE HCL 2% W/V INJECTION (20mg/ml) [Gulf Inject]

LIDOCAINE HCL 2% w/v INJECTION (20 mg/mL) [Gulf Inject] is a sterile solution for injection, designed for local anesthesia and other medical procedures requiring nerve blockage. The formulation contains 2% Lidocaine Hydrochloride, providing 20 mg of Lidocaine per 1 mL. It is packaged in 5 mL LDPE ampoules and is intended for professional medical use only.

• Concentration: 2% w/v (20 mg/mL)
• Total Lidocaine Content: 100 mg per 5 mL ampoule
• Pharmacological Class: Local anesthetic (amide-type)
• Common Uses: Local anesthesia for minor surgical procedures, dental work, or nerve blocks.

This solution is commonly used in hospitals or clinics for short-term localized pain relief. It is essential that it is administered under the supervision of healthcare professionals.

How to use LIDOCAINE HCL 2% W/V INJECTION (20mg/ml) [Gulf Inject]

Lidocaine HCL 2% w/v is designed for parenteral (injection) administration only. Below are typical guidelines for use:

• Infiltration Anesthesia: Administer 5–10 mL (100–200 mg) of solution depending on the size of the area to be anesthetized.
• Nerve Block: Inject 3–5 mL per nerve to block pain effectively in a specific region.
• Maximum Dosage: The total dose should not exceed 4.5 mg/kg of body weight. Adjustments may be required based on the patient’s condition and procedure.
• Single-Use: This solution is intended for single-dose use. Discard any unused solution after administration.

It is crucial to ensure that the solution is administered by a trained healthcare professional to avoid complications and side effects.

Mode of Action LIDOCAINE HCL 2% W/V INJECTION (20mg/ml) [Gulf Inject]

Lidocaine works by inhibiting sodium ion influx through voltage-gated sodium channels in nerves, leading to the stabilization of the neuronal membrane. This prevents the generation and conduction of nerve impulses, resulting in local numbness in the treated area. For emergency arrhythmias, Lidocaine suppresses abnormal electrical activity in the heart.

• Local Anesthesia: Blocks nerve signals, leading to temporary loss of sensation in the treated area.
• Antiarrhythmic Action: Lidocaine stabilizes the cardiac membrane and restores normal heart rhythms, particularly in cases of ventricular arrhythmias.
• Rapid Onset: Anesthetic effects are typically achieved within minutes of administration.
• Duration: The duration of action for local anesthesia ranges from 30 minutes to 2 hours, depending on dosage and the specific area treated.

LIDOCAINE HCL 2% W/V INJECTION (20mg/ml) [Gulf Inject] Interactions LIDOCAINE HCL 2% W/V INJECTION (20mg/ml) [Gulf Inject]

Certain medications can interact with Lidocaine, either increasing its effects or causing side effects. Below are some notable interactions:

• Beta-blockers (e.g., propranolol): These can increase plasma Lidocaine levels, raising the risk of toxicity.
• Amiodarone: Co-administration may elevate Lidocaine levels, which can lead to an increased risk of adverse effects.
• CYP3A4 Inhibitors (e.g., ketoconazole, erythromycin): These may slow the metabolism of Lidocaine, leading to an increased risk of side effects.
• Rifampin and Phenytoin: These medications can speed up Lidocaine metabolism, reducing its effectiveness.
• Other Local Anesthetics: The use of other local anesthetics simultaneously may increase the risk of systemic toxicity, particularly in the central nervous and cardiovascular systems.

Always consult with a healthcare provider before using Lidocaine alongside other medications to avoid harmful interactions.

Dosage of LIDOCAINE HCL 2% W/V INJECTION (20mg/ml) [Gulf Inject]

The dosage of Lidocaine varies based on the procedure and the patient's condition. Below are typical dosages for different uses:

• Infiltration Anesthesia: The standard dose is 5–10 mL (100–200 mg) depending on the area and type of procedure being performed.
• Nerve Block: Typically, 3–5 mL of Lidocaine per nerve for effective block.
• Maximum Dose: For adults, the maximum recommended dose is 4.5 mg/kg body weight, with a typical upper limit of 300 mg. For procedures that require epinephrine, the upper limit can increase.

It is important that dosing is individualized based on patient response and specific procedural needs.

Possible side effects of LIDOCAINE HCL 2% W/V INJECTION (20mg/ml) [Gulf Inject]

While Lidocaine is generally well tolerated, there are potential side effects, especially with improper dosing or administration. Common side effects may include:

• Local Reactions: Pain, redness, or swelling at the injection site.
• CNS Symptoms: Dizziness, confusion, blurred vision, or seizures in case of overdose or rapid administration.
• Cardiovascular Effects: Bradycardia, hypotension, or arrhythmias (more likely with high doses).
• Allergic Reactions: Rash, itching, or severe reactions such as anaphylaxis (though rare).

Any severe side effects, particularly those affecting the heart or nervous system, require immediate medical attention.

LIDOCAINE HCL 2% W/V INJECTION (20mg/ml) [Gulf Inject] Contraindications LIDOCAINE HCL 2% W/V INJECTION (20mg/ml) [Gulf Inject]

• Known hypersensitivity to Lidocaine or other amide-type local anesthetics
• Severe heart block or AV block without a pacemaker
• Severe liver impairment
• Porphyria
• Active infection at the injection site

Patients with these conditions should not receive Lidocaine without consultation with a healthcare provider.

Storage of LIDOCAINE HCL 2% W/V INJECTION (20mg/ml) [Gulf Inject]

• Store at room temperature (15°C to 30°C / 59°F to 86°F).
• Protect from light and avoid freezing.
• Use only once, and discard any unused solution immediately.
• Keep out of reach of children.

Always check the product before use to ensure the solution is clear and free from particles.