LIDOCAINE HCL 1% w/v SINGLE DOSE (10mg/ml) [Gulf Inject] Injection/Solution for

What is LIDOCAINE HCL 1% w/v SINGLE DOSE (10mg/ml) [Gulf Inject]

LIDOCAINE HCL 1% w/v SINGLE DOSE (10 mg/mL) [Gulf Inject] is a sterile, preservative-free injectable solution designed for single-use applications. It contains 1% Lidocaine Hydrochloride, providing 10 mg of Lidocaine per 1 mL. This formulation is intended for local anesthesia, as well as for emergency arrhythmia management. The product is delivered in a 15 mL LDPE ampoule.

• Concentration: 1% w/v (10 mg/mL)
• Total Lidocaine Content: 150 mg per 15 mL ampoule
• Pharmacological Class: Local anesthetic (amide-type) and antiarrhythmic
• Common Uses: Local anesthesia for minor surgical procedures, dental work, and in emergency settings for arrhythmia management

This solution is suitable for professional use in hospitals or clinics where precise control over anesthetic dosing is required.

How to use LIDOCAINE HCL 1% w/v SINGLE DOSE (10mg/ml) [Gulf Inject]

LIDOCAINE HCL 1% w/v SINGLE DOSE is designed for parenteral (injection) administration. It should only be used under medical supervision by qualified healthcare professionals.

• Infiltration Anesthesia: Administer 5–10 mL (50–100 mg) depending on the procedure and the size of the area to be anesthetized.
• Nerve Block: For specific nerve blocks, use approximately 3–5 mL per nerve.
• Emergency Arrhythmia: For ventricular arrhythmias, the recommended initial dose is 1–1.5 mg/kg body weight intravenously, with the potential for a continuous infusion thereafter.
• Single-Use Only: Dispose of any unused solution immediately after opening the ampoule.

Always ensure the patient is monitored closely, especially during intravenous use, as lidocaine can affect heart rhythm and other vital functions.

Mode of Action LIDOCAINE HCL 1% w/v SINGLE DOSE (10mg/ml) [Gulf Inject]

Lidocaine acts by inhibiting sodium ion influx through voltage-gated sodium channels in nerves and the heart. This results in the blockage of nerve signal transmission, leading to local anesthesia. When used intravenously for arrhythmias, it stabilizes the cardiac membrane and suppresses abnormal electrical impulses.

• Local Anesthesia: Blocks nerve fibers responsible for pain transmission, leading to a temporary loss of sensation.
• Antiarrhythmic Effect: Lidocaine stabilizes the cardiac membrane by inhibiting sodium influx during depolarization, which normalizes heart rhythm in cases of arrhythmia.
• Rapid Onset: Anesthetic effects occur within minutes of administration.
• Duration: Anesthesia typically lasts between 30 minutes and 2 hours depending on the site and dosage.

LIDOCAINE HCL 1% w/v SINGLE DOSE (10mg/ml) [Gulf Inject] Interactions LIDOCAINE HCL 1% w/v SINGLE DOSE (10mg/ml) [Gulf Inject]

Certain medications can interact with Lidocaine, potentially altering its effects or increasing the risk of side effects.

• Beta-blockers (e.g., propranolol): May elevate plasma lidocaine levels, increasing the risk of toxicity.
• Amiodarone: Co-administration may increase lidocaine concentrations, raising the risk of adverse cardiovascular effects.
• CYP3A4 Inhibitors (e.g., ketoconazole, erythromycin): These may inhibit the metabolism of lidocaine, leading to elevated blood levels.
• Rifampin, Phenytoin: These drugs may speed up lidocaine metabolism, reducing its effectiveness.
• Other Local Anesthetics: Use with other local anesthetics can increase the risk of toxicity, particularly in the central nervous and cardiovascular systems.

Always consult with a healthcare professional before administering lidocaine alongside other medications.

Dosage of LIDOCAINE HCL 1% w/v SINGLE DOSE (10mg/ml) [Gulf Inject]

Dosage depends on the procedure, patient condition, and the area of application. Below are typical guidelines:

• Local Anesthesia (Infiltration): Typically 5–10 mL (50–100 mg) per site, depending on the extent of anesthesia required.
• Nerve Block: 3–5 mL per nerve, adjusted based on the type of block and the area affected.
• Emergency Arrhythmia (IV Use): 1–1.5 mg/kg body weight as an initial bolus, followed by a continuous infusion of 1–4 mg/min if necessary.
• Maximum Dosage: The maximum recommended dose for adults is 4.5 mg/kg, not to exceed 300 mg. For use with epinephrine, the limit can be raised slightly (up to 7 mg/kg).

Ensure the patient’s clinical status is taken into account when determining the dosage, especially in individuals with pre-existing health conditions.

Possible side effects of LIDOCAINE HCL 1% w/v SINGLE DOSE (10mg/ml) [Gulf Inject]

Like all medications, lidocaine may cause side effects. These are typically more likely when the drug is administered in excess or improperly.

• Local Reactions: Pain, redness, or swelling at the injection site.
• CNS Symptoms: Dizziness, tinnitus, blurred vision, confusion, or, in severe cases, seizures.
• Cardiovascular Reactions: Bradycardia, hypotension, or arrhythmias, particularly in high doses or when administered intravenously.
• Allergic Reactions: Rash, itching, or anaphylaxis (though rare).

Immediate medical intervention may be necessary if severe symptoms arise, particularly if the patient develops signs of lidocaine toxicity.

LIDOCAINE HCL 1% w/v SINGLE DOSE (10mg/ml) [Gulf Inject] Contraindications LIDOCAINE HCL 1% w/v SINGLE DOSE (10mg/ml) [Gulf Inject]

• Hypersensitivity to lidocaine or any other amide-type local anesthetic
• Severe heart block or advanced atrioventricular (AV) block (unless a pacemaker is in place)
• Severe liver disease
• Porphyria
• Active infection or severe inflammation at the injection site

It is essential to confirm the patient does not have any of these contraindications before administering the drug.

Storage of LIDOCAINE HCL 1% w/v SINGLE DOSE (10mg/ml) [Gulf Inject]

• Store at room temperature between 15°C and 30°C (59°F–86°F)
• Do not freeze
• Keep the ampoules sealed and protected from light
• Dispose of any unused portion after opening

Inspect the solution for clarity and particulate matter before use. Do not use if the solution appears discolored or contains visible particles.