LIDOCAINE HCL 1% w/v SINGLE DOSE (10mg/ml) [Gulf Inject] Injection/Solution for

What is LIDOCAINE HCL 1% w/v SINGLE DOSE (10mg/ml) [Gulf Inject]

LIDOCAINE HCL 1% w/v SINGLE DOSE (10 mg/mL) [Gulf Inject] is a sterile injectable solution of Lidocaine Hydrochloride formulated for single use. It is provided in a 10 mL ampoule containing a 1% concentration of Lidocaine, making it a versatile agent for local anesthesia and certain emergency applications. Lidocaine is a local anesthetic and antiarrhythmic drug that blocks nerve signals in the body.

• Concentration: 1% w/v (10 mg/mL)
• Total Lidocaine Content: 100 mg per 10 mL ampoule
• Pharmacological Class: Local anesthetic (amide-type) and antiarrhythmic
• Common Uses: Local anesthesia for minor surgeries, dental procedures, and emergency management of arrhythmias

This formulation is ideal for precise local anesthetic effect and is suitable for use in clinical settings where a single-dose, preservative-free solution is required.

How to use LIDOCAINE HCL 1% w/v SINGLE DOSE (10mg/ml) [Gulf Inject]

LIDOCAINE HCL 1% w/v SINGLE DOSE is intended for parenteral (injection) administration and should only be used under medical supervision.

• Infiltration Anesthesia: Administer 5–10 mL (50–100 mg) depending on the extent of the area to be anesthetized. This is common for minor procedures such as suturing or dental work.
• Nerve Block: Typically, 3–5 mL per nerve depending on the nerve block procedure.
• Emergency Arrhythmia (IV Administration): For ventricular arrhythmias, administer an initial bolus of 1–1.5 mg/kg IV, followed by a continuous infusion if needed. Always adjust based on the patient’s condition and clinical response.
• Discard Unused Portion: This product is for single-use only. Any unused portion should be discarded after the injection.

Ensure careful monitoring of the patient during and after administration, particularly when lidocaine is used intravenously in emergency settings.

Mode of Action LIDOCAINE HCL 1% w/v SINGLE DOSE (10mg/ml) [Gulf Inject]

Lidocaine acts primarily by inhibiting sodium ion influx into nerve cells, thereby blocking action potentials. This results in a loss of sensation in the localized area. In the heart, lidocaine suppresses abnormal electrical activity by stabilizing the cell membrane and blocking sodium channels during depolarization, making it effective for managing arrhythmias.

• Local Anesthesia: Lidocaine works by blocking the nerve fibers responsible for transmitting pain signals, leading to temporary numbness in the targeted area.
• Antiarrhythmic Effect: In cases of arrhythmia, lidocaine stabilizes the cardiac membrane and normalizes the heart rhythm by inhibiting sodium influx during depolarization.
• Onset of Action: Effects are typically rapid, with local anesthesia occurring within 2–5 minutes after injection.
• Duration of Action: Local anesthesia typically lasts from 30 minutes to 2 hours, depending on the dosage and location.

LIDOCAINE HCL 1% w/v SINGLE DOSE (10mg/ml) [Gulf Inject] Interactions LIDOCAINE HCL 1% w/v SINGLE DOSE (10mg/ml) [Gulf Inject]

Several drugs may interact with lidocaine, particularly those affecting its metabolism or influence on the heart’s rhythm.

• Beta-blockers (e.g., propranolol): These may increase lidocaine plasma concentrations, potentially leading to toxicity.
• Amiodarone: Concomitant use can lead to elevated lidocaine levels, increasing the risk of toxicity, particularly in the cardiovascular system.
• CYP3A4 Inhibitors (e.g., ketoconazole, erythromycin): These drugs may inhibit lidocaine metabolism, raising blood levels and increasing the risk of adverse effects.
• Other Local Anesthetics: Using lidocaine with other anesthetics may increase the risk of CNS and cardiovascular toxicity.
• Rifampin, Phenytoin: These may accelerate lidocaine metabolism, reducing its effectiveness.

Prior to administration, it’s important to review the patient’s current medication list to avoid potential drug interactions.

Dosage of LIDOCAINE HCL 1% w/v SINGLE DOSE (10mg/ml) [Gulf Inject]

The appropriate dosage of LIDOCAINE HCL 1% w/v SINGLE DOSE depends on the intended use and the patient’s condition. The following are general guidelines:

• Local Anesthesia (Infiltration): Typically, 5–10 mL (50–100 mg) per site, depending on the size and depth of the area to be anesthetized.
• Nerve Block: For nerve block procedures, 3–5 mL per nerve is typically used.
• Emergency Arrhythmia (IV Use): For ventricular arrhythmias, administer 1–1.5 mg/kg body weight as an initial bolus. A continuous infusion may follow as needed, typically at a dose of 1–4 mg/min.
• Maximum Dosage: In adults, the maximum recommended dose is 4.5 mg/kg of body weight, or up to 300 mg. If used with epinephrine, the maximum dose can be slightly higher, up to 7 mg/kg.

Adjust the dosage based on the patient's clinical condition, age, and weight. Always consult dosage guidelines and recommendations before administering.

Possible side effects of LIDOCAINE HCL 1% w/v SINGLE DOSE (10mg/ml) [Gulf Inject]

Although lidocaine is generally safe when used appropriately, it may cause side effects, especially if overdosed or if there is accidental systemic absorption.

• Local Reactions: Redness, swelling, or pain at the injection site.
• CNS Effects: Dizziness, confusion, blurred vision, or more severe effects such as seizures in the case of toxicity.
• Cardiovascular Effects: Bradycardia, hypotension, or arrhythmias, particularly with IV administration.
• Allergic Reactions: Skin rash, itching, or, in rare cases, anaphylaxis.

Careful monitoring is required, especially when administering large doses or using lidocaine intravenously.

LIDOCAINE HCL 1% w/v SINGLE DOSE (10mg/ml) [Gulf Inject] Contraindications LIDOCAINE HCL 1% w/v SINGLE DOSE (10mg/ml) [Gulf Inject]

• Hypersensitivity to lidocaine or other amide-type local anesthetics
• Severe heart block or advanced AV block (unless a pacemaker is in place)
• Severe hepatic dysfunction
• Porphyria
• Infected or inflamed tissue at the injection site

Confirm that the patient does not have any contraindications before administering lidocaine.

Storage of LIDOCAINE HCL 1% w/v SINGLE DOSE (10mg/ml) [Gulf Inject]

• Store at room temperature between 15°C and 30°C (59°F–86°F)
• Do not freeze
• Protect from light and keep ampoules sealed
• Discard any unused solution after the ampoule is opened

Check the ampoule for any visible defects or discoloration before use. Only use the solution if it appears clear and free from particles.