LEVOTIRON 100 mcg Tablet

What is LEVOTIRON 100 mcg

LEVOTIRON 100 mcg is an oral tablet formulation containing Levothyroxine Sodium (also known as Thyroxine Sodium), a synthetic form of the naturally occurring thyroid hormone, thyroxine (T4). It is used primarily for the treatment of hypothyroidism—a condition where the thyroid gland does not produce enough thyroid hormones.

Key highlights:

• Generic Name: Thyroxine (Levothyroxine Sodium)
• Form: Tablet
• Strength: 100 micrograms (mcg)
• Primary Use: To replace or supplement natural thyroid hormones in hypothyroid patients, and sometimes used to suppress thyroid-stimulating hormone (TSH) in the management of certain thyroid tumors.
• Benefits: Restores normal metabolic activity, energy levels, and overall bodily functions regulated by thyroid hormones.

How to use LEVOTIRON 100 mcg

Using LEVOTIRON 100 mcg correctly is essential to achieve the desired therapeutic outcomes and minimize potential risks.

Usage instructions:

• Take LEVOTIRON 100 mcg orally, ideally on an empty stomach.
• It is recommended to take the tablet at least 30 to 60 minutes before breakfast with a full glass of water.
• Swallow the tablet whole without crushing or chewing to ensure proper absorption.
• Consistency in timing is crucial; take it at the same time every day.
• If you are taking calcium, iron supplements, or antacids, maintain a gap of 4 hours after taking LEVOTIRON to avoid absorption issues.
• Regular blood tests may be necessary to adjust your dose and monitor thyroid levels.

Mode of Action LEVOTIRON 100 mcg

LEVOTIRON 100 mcg acts by supplementing the body with synthetic thyroxine (T4), mimicking the function of the natural thyroid hormone, essential for maintaining normal metabolism, growth, and development.

Mechanism details:

• Levothyroxine is absorbed into the bloodstream and then converted into the more active form, triiodothyronine (T3), inside body tissues.
• T3 binds to thyroid hormone receptors located in the nucleus of cells, regulating gene expression.
• It influences protein synthesis, energy metabolism, and enzyme activity throughout the body.
• By normalizing thyroid hormone levels, LEVOTIRON helps restore normal metabolic rate, cardiac function, digestive health, and neurological balance.

LEVOTIRON 100 mcg Interactions LEVOTIRON 100 mcg

LEVOTIRON 100 mcg can interact with various other medications and supplements, potentially affecting its absorption or efficacy. It's important to manage these interactions to avoid reduced therapeutic effects or increased risk of side effects.

Important drug interactions:

• Antacids, calcium carbonate, and iron supplements: Decrease absorption of Levothyroxine; maintain at least 4 hours gap.
• Warfarin: Levothyroxine may enhance anticoagulant effects; monitor INR levels closely.
• Diabetes medications (e.g., insulin, metformin): May require dosage adjustments as Levothyroxine can affect glucose control.
• Antidepressants (e.g., sertraline, amitriptyline): May alter thyroid hormone levels or increase effects.
• Enzyme-inducing drugs (e.g., rifampin, carbamazepine, phenytoin): May increase metabolism of Levothyroxine, reducing its effectiveness.

Dosage of LEVOTIRON 100 mcg

The dosage of LEVOTIRON 100 mcg is highly individualized and must be tailored based on age, weight, cardiac status, and the severity of hypothyroidism. It is crucial to follow your healthcare provider’s specific instructions.

General dosage guidelines:

• Initial dose for healthy adults: 50-100 mcg daily; adjusted by 25-50 mcg increments every 4-6 weeks based on TSH response.
• Elderly or cardiac patients: Start at a lower dose, such as 12.5-25 mcg daily, to minimize cardiac stress.
• Maintenance dose: Typically 100-200 mcg daily to achieve normal TSH and T4 levels.
• Children: Doses vary by age and body weight; careful monitoring is needed.
• Monitoring: Thyroid function tests (TSH and free T4) should be assessed every 6-8 weeks initially and whenever a dosage change is made.

Possible side effects of LEVOTIRON 100 mcg

While LEVOTIRON 100 mcg is generally well-tolerated when dosed appropriately, incorrect dosing can lead to symptoms of hyperthyroidism or adverse effects.

Common side effects (usually due to overdosage):

• Palpitations or rapid heart rate (tachycardia)
• Increased appetite and weight loss
• Heat intolerance and excessive sweating
• Nervousness, anxiety, or irritability
• Insomnia or trouble sleeping
• Diarrhea or increased bowel movements

Serious adverse reactions (seek medical help):

• Chest pain or signs of heart attack
• Shortness of breath
• Seizures
• Severe allergic reactions (rash, itching/swelling)

LEVOTIRON 100 mcg Contraindications LEVOTIRON 100 mcg

There are specific situations where LEVOTIRON 100 mcg should not be used, or used with extreme caution. Identifying these conditions beforehand can help avoid serious complications.

Contraindications:

• Known hypersensitivity to Levothyroxine or any component of the formulation
• Untreated thyrotoxicosis (overactive thyroid)
• Uncorrected adrenal insufficiency (e.g., Addison’s disease)
• Acute myocardial infarction (heart attack)
• Difficulty swallowing tablets (in which case alternative formulations may be considered)

Storage of LEVOTIRON 100 mcg

Proper storage of LEVOTIRON 100 mcg is crucial to maintain its potency and effectiveness throughout its shelf life.

Storage recommendations:

• Store tablets at room temperature between 15°C and 30°C (59°F to 86°F).
• Protect from light and moisture; always keep tablets in their original blister packs until use.
• Do not store in humid environments such as bathrooms.
• Keep out of reach and sight of children and pets.
• Dispose of any expired medication safely and as per local regulations.