LEVOTAB 500 Tablets/Film-coated

What is LEVOTAB 500

LEVOTAB 500 is a film-coated oral tablet containing Levofloxacin as its active ingredient. Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic that is highly effective against a wide variety of bacterial infections. LEVOTAB 500 is particularly useful in treating respiratory tract infections, urinary tract infections, skin infections, and certain gastrointestinal infections.

Key highlights:

• Generic Name: Levofloxacin
• Form: Film-coated oral tablet
• Strength: 500mg
• Primary Use: Management of bacterial infections where other antibiotics may not be effective.
• Advantages: Convenient once-daily dosing with excellent oral absorption and systemic availability.

How to use LEVOTAB 500

Correct usage of LEVOTAB 500 ensures maximum effectiveness and reduces the risk of side effects or resistance. Always follow your healthcare provider's instructions precisely.

Usage instructions:

• Take LEVOTAB 500 orally, with or without food.
• Swallow the tablet whole with a sufficient amount of water; do not crush or chew the tablet.
• Administer at the same time each day to maintain even levels of the drug in your body.
• If you are taking antacids, iron supplements, or multivitamins, ensure at least a 2-hour gap before or after LEVOTAB 500 to prevent reduced absorption.
• Complete the full course of therapy, even if symptoms improve earlier, to prevent bacterial resistance.
• If you miss a dose, take it as soon as possible. If it’s close to your next dose, skip the missed dose—do not double up.

Mode of Action LEVOTAB 500

LEVOTAB 500 works through a potent bactericidal mechanism by targeting bacterial DNA replication processes, effectively killing the bacteria and stopping the infection.

Mechanism details:

• Inhibits bacterial enzymes known as DNA gyrase and topoisomerase IV.
• DNA gyrase is essential for supercoiling of DNA, necessary for DNA replication and transcription.
• Topoisomerase IV is vital for the separation of replicated DNA strands before bacterial cell division.
• By blocking these critical enzymes, LEVOTAB 500 prevents bacterial reproduction and survival.
• This mechanism gives LEVOTAB broad-spectrum activity against Gram-positive, Gram-negative, and atypical bacteria.

LEVOTAB 500 Interactions LEVOTAB 500

Several drug interactions can influence the effectiveness and safety of LEVOTAB 500. Being aware of these is critical for optimal treatment outcomes.

Important drug interactions:

• Antacids containing aluminum, magnesium, or calcium: Reduce the absorption of Levofloxacin. Administer with a time gap.
• Warfarin: Enhanced anticoagulant effects leading to increased bleeding risk; monitor INR closely.
• Antiarrhythmic drugs (e.g., amiodarone, sotalol): Increase the risk of QT prolongation.
• NSAIDs (e.g., ibuprofen): Can increase the risk of central nervous system side effects like seizures.
• Oral hypoglycemics and insulin: Risk of blood sugar disturbances; monitor glucose regularly.

Dosage of LEVOTAB 500

The dosage of LEVOTAB 500 must be carefully tailored to the infection type, severity, patient's renal function, and response to therapy. Always consult a healthcare provider for individual dosing instructions.

Common dosage recommendations:

• Community-acquired pneumonia: 500mg once daily for 7–14 days.
• Urinary tract infections (complicated or uncomplicated): 500mg once daily for 7–10 days.
• Acute bacterial sinusitis: 500mg once daily for 10–14 days.
• Skin and soft tissue infections: 500mg once daily for 7–14 days.
• Renal impairment: Dosage adjustment is required based on creatinine clearance (CrCl).

Possible side effects of LEVOTAB 500

While LEVOTAB 500 is generally safe and effective, like all medications, it can cause side effects in some individuals. Awareness allows for early detection and management.

Common side effects:

• Gastrointestinal upset (nausea, diarrhea, vomiting)
• Headache, dizziness, or lightheadedness
• Insomnia or difficulty sleeping
• Changes in taste sensation

Serious adverse reactions (seek immediate medical care):

• Tendon rupture or inflammation, especially in older adults
• Peripheral neuropathy (numbness, burning, or weakness)
• Severe allergic reactions such as swelling, difficulty breathing, or rash
• QT interval prolongation leading to serious heart rhythm disturbances
• Mental health changes including confusion, hallucinations, depression, or suicidal thoughts

LEVOTAB 500 Contraindications LEVOTAB 500

There are specific situations where LEVOTAB 500 should not be used due to a heightened risk of serious adverse events. Always discuss your full medical history with your healthcare provider before starting therapy.

Contraindications:

• Hypersensitivity to Levofloxacin, other quinolone antibiotics, or any tablet components
• History of tendon disorders related to fluoroquinolone use
• Children or adolescents under 18 years old (due to risk of musculoskeletal disorders)
• Pregnant or breastfeeding women unless benefits outweigh risks
• Patients with epilepsy or history of seizures
• Patients with known QT prolongation or uncorrected electrolyte imbalances

Storage of LEVOTAB 500

Proper storage ensures that LEVOTAB 500 maintains its quality and efficacy until the end of its shelf life.

Storage instructions:

• Store at controlled room temperature, between 15°C and 30°C (59°F and 86°F).
• Keep tablets in their original blister packaging until use to protect them from moisture and light.
• Do not use tablets past the expiration date printed on the package.
• Keep out of reach of children and pets.
• Do not store in bathrooms or near damp areas to prevent tablet degradation.