What is ADDAVEN
ADDAVEN is a concentrate formulated for preparation of an intravenous infusion solution, designed to provide essential trace elements required for normal metabolic and physiological functions. It is supplied in 10 ml polypropylene ampoules, typically in packs of 20.
This medication contains a combination of vital trace elements, including:
- Chromic chloride hexahydrate
- Copper chloride dihydrate
- Ferric chloride hexahydrate
- Manganese chloride tetrahydrate
- Potassium iodide
- Sodium fluoride
- Sodium molybdate dihydrate
- Sodium selenite anhydrous
- Zinc chloride
The trace elements contained in ADDAVEN play crucial roles in enzymatic reactions, antioxidant defense, hormone production, and immune system maintenance. It is primarily used in clinical settings for patients who require parenteral supplementation due to malnutrition, malabsorption, or during total parenteral nutrition (TPN).
ADDAVEN helps to prevent or treat deficiencies of these trace elements in individuals unable to absorb sufficient amounts through oral intake, such as those with gastrointestinal disorders, burns, chronic illnesses, or post-surgical recovery.
How to use ADDAVEN
The administration of ADDAVEN requires careful preparation and monitoring:
- Route: Administered intravenously after dilution according to specific protocols.
- Preparation: The concentrate must be diluted in a compatible infusion solution, usually as part of a total parenteral nutrition regimen.
- Infusion: Infuse slowly to reduce the risk of vein irritation and adverse reactions.
- Dosage regimen: Dosage is individualized based on the patient’s clinical condition, laboratory monitoring of trace element levels, and nutritional needs.
- Monitoring: Regular monitoring of serum trace elements, electrolytes, and clinical parameters is essential to avoid toxicity or deficiency.
- Compatibility: Confirm compatibility with other medications and parenteral nutrition components prior to co-administration.
- Administration environment: Should be administered under sterile conditions by trained healthcare professionals.
Any deviation from recommended preparation and infusion procedures may compromise patient safety and treatment efficacy.
Mode of Action ADDAVEN
ADDAVEN acts by supplying essential trace elements that function as cofactors and structural components in numerous physiological processes:
- Chromium: Enhances insulin action and supports carbohydrate, lipid, and protein metabolism.
- Copper: Vital for enzymatic processes involved in energy production, connective tissue synthesis, and antioxidant defense.
- Iron (Ferric chloride): Central to oxygen transport via hemoglobin and myoglobin.
- Manganese: Participates in amino acid, lipid, and carbohydrate metabolism and bone formation.
- Potassium iodide: Necessary for thyroid hormone biosynthesis, regulating metabolism and growth.
- Sodium fluoride: Supports bone mineralization and dental health.
- Molybdenum: Cofactor for enzymes involved in detoxification and metabolism of sulfur-containing amino acids.
- Selenium: Integral to antioxidant enzymes like glutathione peroxidase, protecting cells from oxidative stress.
- Zinc: Critical for immune function, wound healing, DNA synthesis, and cell division.
By restoring adequate levels of these elements, ADDAVEN supports normal enzymatic functions, immune defense, growth, and tissue repair in patients with deficiencies.
ADDAVEN Interactions ADDAVEN
Due to its multiple trace elements, ADDAVEN may interact with various drugs and substances, including:
- Chelating agents: Drugs like penicillamine, EDTA, or tetracyclines can chelate metals such as copper, zinc, and iron, reducing their bioavailability.
- Antibiotics: Certain antibiotics (e.g., fluoroquinolones, tetracyclines) may form complexes with metals, reducing absorption or efficacy.
- Thyroid medications: Iodide in ADDAVEN can affect thyroid hormone synthesis and may interfere with thyroid treatment.
- Diuretics: Medications that alter potassium and magnesium levels may affect trace element balance.
- Other mineral supplements: Concurrent administration of oral or intravenous trace elements may cause additive effects or imbalances.
- Drugs metabolized by the liver: Elements like copper and molybdenum influence hepatic enzyme systems, potentially altering drug metabolism.
Always inform the healthcare provider of all medications being taken to manage potential interactions effectively.
Dosage of ADDAVEN
The dosage of ADDAVEN depends on the individual patient’s clinical condition, nutritional status, and laboratory evaluations:
- Standard dosing: Typically, one 10 ml ampoule diluted appropriately and administered once daily, or as recommended by the healthcare provider.
- Adjustments: Dose should be tailored according to serum trace element concentrations to avoid deficiency or toxicity.
- Duration: The length of therapy depends on the patient’s needs, which may range from a few days to several weeks.
- Special populations: Dose modifications may be necessary for patients with renal or hepatic impairment.
- Monitoring: Frequent blood tests to monitor trace element levels and organ function are essential during therapy.
Clinical judgment and laboratory monitoring guide precise dosing to optimize therapeutic outcomes safely.
Possible side effects of ADDAVEN
Possible side effects of ADDAVEN stem from its components or intravenous administration and may include:
- Local reactions: Pain, irritation, or thrombophlebitis at the infusion site.
- Allergic responses: Rash, itching, fever, chills, or rare anaphylactic reactions.
- Metal toxicity symptoms:
- Copper overload: May cause nausea, vomiting, jaundice, or neurological symptoms.
- Iron toxicity: Can lead to oxidative tissue damage and systemic toxicity if overdosed.
- Manganese excess: Neurological symptoms like tremors or muscle stiffness.
- Zinc overdose: Gastrointestinal upset and interference with copper absorption.
- Electrolyte imbalance: Imbalance of potassium, magnesium, or other electrolytes potentially causing cardiac or neuromuscular effects.
- Systemic reactions: Fever, malaise, or chills during or following infusion.
Any adverse effects should be reported promptly to a healthcare professional.
ADDAVEN Contraindications ADDAVEN
ADDAVEN should not be used in patients with:
- Known hypersensitivity: Allergy to any ingredient in the formulation.
- Severe renal insufficiency: Risk of trace element accumulation and toxicity.
- Metal overload disorders: Such as hemochromatosis or Wilson’s disease, where iron or copper accumulation occurs.
- Metabolic disorders: Disorders affecting mineral metabolism that contraindicate supplementation.
- Active infections: Use cautiously as some trace elements can influence microbial growth or immune responses.
Use only under strict medical supervision with appropriate monitoring.
Storage of ADDAVEN
Proper storage is essential for maintaining the safety and efficacy of ADDAVEN:
- Temperature: Store refrigerated at 2°C to 8°C. Avoid freezing.
- Light protection: Keep ampoules in original packaging to protect from light exposure.
- Inspection: Check ampoules for discoloration or particulate matter before use. Do not use if compromised.
- Expiration: Do not use beyond the expiry date indicated on the packaging.
- Handling: Maintain aseptic conditions when preparing and administering the solution.
- Disposal: Dispose of unused or expired product as per local regulations for pharmaceutical waste.
Adhering to storage guidelines preserves the medication’s integrity and safety.
ADDAVEN features an exceptional active ingredient renowned for its potent effects, comprising Chromic chloride hexahydrate ,
Copper chloride dihydrate,
Ferric chloride hexahydrate,
Manganese chloride tetrahydrate,
Potassium iodide,
Sodium fluoride,
Sodium molybdate dihydrate,
Sodium selenite anhydrous,
Zinc chloride. This powerful formulation provides a superior solution for addressing diverse health concerns. With 53.3 µg/10 ml, 1.02 mg /10 ml, 5.40 mg/10 ml , 198 µg/10 ml, 166 µg/10 ml, 2.10 mg/10 ml, 48.5 µg/10 ml, 173 µg/ 10 ml, 10.5 mg/10 ml concentration and an easily manageable Concentrate for solution for infusion, it remains a preferred option for countless individuals seeking effective treatment.
Introduction
All you need to know about ADDAVEN .
Welcome to Dwaey, specifically on ADDAVEN page.
This medicine contains an important and useful components, as it consists of Chromic chloride hexahydrate ,
Copper chloride dihydrate,
Ferric chloride hexahydrate,
Manganese chloride tetrahydrate,
Potassium iodide,
Sodium fluoride,
Sodium molybdate dihydrate,
Sodium selenite anhydrous,
Zinc chloride.
ADDAVEN is available in the market in concentration 53.3 µg/10 ml, 1.02 mg /10 ml, 5.40 mg/10 ml , 198 µg/10 ml, 166 µg/10 ml, 2.10 mg/10 ml, 48.5 µg/10 ml, 173 µg/ 10 ml, 10.5 mg/10 ml and in the form of Concentrate for solution for infusion.
FRESENIUS KABI NORGE AS is the producer of ADDAVEN and it is imported from NORWAY,
The most popular alternatives of ADDAVEN are listed downward .
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Active Substance
Chromic chloride hexahydrate ,
Copper chloride dihydrate,
Ferric chloride hexahydrate,
Manganese chloride tetrahydrate,
Potassium iodide,
Sodium fluoride,
Sodium molybdate dihydrate,
Sodium selenite anhydrous,
Zinc chloride
-
Size
20 Polypropylene Ampoules (10 ml)
-
Indications
- No indications available.
-
Type
Concentrate for solution for infusion
-
Company
Frequently Asked Questions
ADDAVEN should be stored according to the instructions provided by FRESENIUS KABI NORGE AS.
In general, it is recommended to store ADDAVEN in a cool, dry place, away from direct sunlight
and out of the reach of children.
The duration of treatment with ADDAVEN may vary depending on the condition being treated
and the guidance of your healthcare provider. It is important to follow the prescribed treatment
plan and continue taking ADDAVEN for the recommended duration, even if your symptoms improve.
If you have any concerns or questions about the duration of treatment, consult your healthcare provider.
It is important to check with your healthcare provider or read the medication label for specific
instructions regarding alcohol consumption while taking ADDAVEN. Some medications, including
ADDAVEN, may have interactions with alcohol that can reduce effectiveness, increase side
effects, or pose other risks to your health. It is best to follow the guidance provided by your
healthcare professional.
If you miss a dose of ADDAVEN, take it as soon as you remember. However, if it is close
to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing
schedule. Do not take a double dose to make up for a missed one unless advised by your healthcare provider.
No, do not stop taking ADDAVEN without consulting your healthcare provider, even if your
symptoms improve. It is important to complete the full course of treatment as prescribed. Stopping
the medication prematurely may lead to a relapse or incomplete resolution of the condition. If you
have concerns about the duration of treatment, consult your healthcare provider for guidance.
It is important to consult your healthcare provider before taking ADDAVEN if you are
pregnant or breastfeeding. They will be able to assess the potential risks and benefits based on your
specific situation. Please note that the safety and suitability of ADDAVEN during pregnancy
or breastfeeding may depend on the active substance [Active Substance], concentration 53.3 µg/10 ml, 1.02 mg /10 ml, 5.40 mg/10 ml , 198 µg/10 ml, 166 µg/10 ml, 2.10 mg/10 ml, 48.5 µg/10 ml, 173 µg/ 10 ml, 10.5 mg/10 ml ,
and the specific recommendations of FRESENIUS KABI NORGE AS.
The effects of ADDAVEN on your ability to drive or operate machinery can vary depending on
the active substance [Active Substance], concentration 53.3 µg/10 ml, 1.02 mg /10 ml, 5.40 mg/10 ml , 198 µg/10 ml, 166 µg/10 ml, 2.10 mg/10 ml, 48.5 µg/10 ml, 173 µg/ 10 ml, 10.5 mg/10 ml , and individual factors.
Some medications may cause drowsiness, dizziness, or other side effects that can impair your judgment
or coordination. It is important to read the medication label or consult your healthcare provider to
understand any potential effects on your ability to perform tasks that require alertness.
The instructions for taking ADDAVEN with or without food may vary depending on the medication
and the recommendations of FRESENIUS KABI NORGE AS. Some medications may be more effective when taken with
food to enhance absorption or reduce stomach irritation, while others may need to be taken on an empty
stomach for optimal absorption. Read the medication label or consult your healthcare provider for specific instructions.
The use of ADDAVEN in children or elderly individuals may depend on various factors, including
the specific medication, type Concentrate for solution for infusion, and the recommendations of FRESENIUS KABI NORGE AS. Some
medications may have specific dosing instructions or precautions for these age groups. Consult your
healthcare provider or read the medication label for information regarding the safe and appropriate use
of ADDAVEN in children or elderly individuals.
Dwaey
All medical information published on the Dwaey website aims to increase medical awareness and health education among users. However, it is not a substitute for professional medical advice. Always consult with a specialist doctor. We strongly advise against using any information or medicine found on the site without referring to your healthcare provider.
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