What is ADAKVEO 10mg/ml
ADAKVEO (crizanlizumab-tmca) is a humanized monoclonal antibody that targets P-selectin, a cell adhesion molecule involved in the pathophysiology of sickle cell disease (SCD). It is indicated to reduce the frequency of vaso-occlusive crises (VOCs) in adults and pediatric patients aged 16 years and older with SCD.
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Key Features:
Mechanism: Blocks P-selectin to prevent interactions between endothelial cells, platelets, red blood cells, and leukocytes, thereby reducing vaso-occlusion.
Administration: Intravenous infusion over 30 minutes.
Dosage Form: Sterile concentrate solution for infusion, supplied in a 10 mL glass vial containing 100 mg of crizanlizumab-tmca.
Approval: Received FDA approval in November 2019 for the treatment of SCD-related VOCs.
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How to use ADAKVEO 10mg/ml
Administration Guidelines:
Dosage: 5 mg/kg administered by intravenous infusion over 30 minutes at Week 0, Week 2, and every 4 weeks thereafter.
Preparation: Dilute the required dose in 0.9% sodium chloride or 5% dextrose to a total volume of 100 mL. Use infusion bags made of polyvinyl chloride, polyethylene, or polypropylene.
Infusion: Administer through an intravenous line containing a sterile, nonpyrogenic 0.2-micron inline filter.
Post-Infusion: Flush the line with at least 25 mL of 0.9% sodium chloride or 5% dextrose.
Missed Dose: If a dose is missed, administer as soon as possible. If administered within 2 weeks after the missed dose, continue dosing according to the original schedule. If administered more than 2 weeks after the missed dose, continue dosing every 4 weeks thereafter.
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Mode of Action ADAKVEO 10mg/ml
ADAKVEO functions by binding to P-selectin, a cell adhesion molecule expressed on activated endothelial cells and platelets. By inhibiting P-selectin, ADAKVEO prevents the adhesion of sickled red blood cells, leukocytes, and platelets to the endothelium, thereby reducing vascular inflammation and the occurrence of vaso-occlusive crises.
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Mechanistic Highlights:
Target: P-selectin on endothelial cells and platelets.
Effect: Reduces cell-cell interactions that contribute to vaso-occlusion.
Outcome: Decreases the frequency of VOCs in patients with SCD.
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ADAKVEO 10mg/ml Interactions ADAKVEO 10mg/ml
Laboratory Test Interference:
ADAKVEO may interfere with automated platelet counts, particularly when blood samples are collected in tubes containing EDTA, leading to platelet clumping and potentially inaccurate results. To mitigate this:
Use citrate-containing tubes for blood collection.
Run blood samples within 4 hours of collection.
Consider estimating platelet counts via peripheral blood smear when necessary.
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Drug Interactions:
No significant drug-drug interactions have been reported. However, caution is advised when using corticosteroids in patients with SCD, as they may increase the risk of complications such as acute chest syndrome and fat embolism.
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Dosage of ADAKVEO 10mg/ml
Recommended Dosage:
Initial Dose: 5 mg/kg via intravenous infusion over 30 minutes at Week 0 and Week 2.
Maintenance Dose: 5 mg/kg every 4 weeks thereafter.
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Administration Notes:
Use the patient's actual body weight to calculate the dose.
ADAKVEO may be administered with or without hydroxyurea.
Monitor patients for signs and symptoms of infusion-related reactions during and after administration.
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Possible side effects of ADAKVEO 10mg/ml
Common Adverse Reactions (≥10%):
Nausea (18%)
Arthralgia (18%)
Back pain (15%)
Pyrexia (11%)
Fatigue (13%)
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Less Common Side Effects (<10%):
Oropharyngeal pain
Abdominal pain
Diarrhea
Vomiting
Pruritus
Infusion-site reactions
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Serious Adverse Reactions:
Infusion-related reactions, including severe pain events, have been reported, particularly during the first and second infusions. Management may include:
Temporarily interrupting or slowing the infusion rate.
Symptomatic treatment with acetaminophen, NSAIDs, opioids, antihistamines, intravenous fluids, and/or oxygen therapy.
For severe reactions, discontinuation of the infusion and appropriate medical care.
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ADAKVEO 10mg/ml Contraindications ADAKVEO 10mg/ml
There are no known contraindications for ADAKVEO.
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Precautions:
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Animal studies have shown potential fetal harm.
It is unknown whether ADAKVEO is excreted in human milk. Caution should be exercised when administered to breastfeeding women.
Safety and efficacy have not been established in patients younger than 16 years.
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Storage of ADAKVEO 10mg/ml
Storage Conditions:
Store refrigerated at 2°C to 8°C (36°F to 46°F) in the original carton to protect from light.
Do not freeze.
Do not shake.
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In-Use Stability:
If not administered immediately after preparation, the diluted solution may be stored:
At room temperature (up to 25°C or 77°F) for up to 4.5 hours, including infusion time.
Under refrigeration (2°C to 8°C or 36°F to 46°F) for no more than 24 hours, including time to warm up to room temperature.
Protect the diluted solution from light during storage.
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ADAKVEO 10mg/ml features an exceptional active ingredient renowned for its potent effects, comprising Crizanlizumab. This powerful formulation provides a superior solution for addressing diverse health concerns. With 10mg/ml concentration and an easily manageable Sterile Concentrate Solution for infusion, it remains a preferred option for countless individuals seeking effective treatment.
Introduction
All you need to know about ADAKVEO 10mg/ml .
Welcome to Dwaey, specifically on ADAKVEO 10mg/ml page.
This medicine contains an important and useful components, as it consists of Crizanlizumab.
ADAKVEO 10mg/ml is available in the market in concentration 10mg/ml and in the form of Sterile Concentrate Solution for infusion.
NOVARTIS PHARMACEUTICALS CORPORATION is the producer of ADAKVEO 10mg/ml and it is imported from USA,
The most popular alternatives of ADAKVEO 10mg/ml are listed downward .
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Active Substance
-
Size
-
Indications
- No indications available.
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Type
Sterile Concentrate Solution for infusion
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Company
NOVARTIS PHARMACEUTICALS CORPORATION
Frequently Asked Questions
ADAKVEO 10mg/ml should be stored according to the instructions provided by NOVARTIS PHARMACEUTICALS CORPORATION.
In general, it is recommended to store ADAKVEO 10mg/ml in a cool, dry place, away from direct sunlight
and out of the reach of children.
The duration of treatment with ADAKVEO 10mg/ml may vary depending on the condition being treated
and the guidance of your healthcare provider. It is important to follow the prescribed treatment
plan and continue taking ADAKVEO 10mg/ml for the recommended duration, even if your symptoms improve.
If you have any concerns or questions about the duration of treatment, consult your healthcare provider.
It is important to check with your healthcare provider or read the medication label for specific
instructions regarding alcohol consumption while taking ADAKVEO 10mg/ml. Some medications, including
ADAKVEO 10mg/ml, may have interactions with alcohol that can reduce effectiveness, increase side
effects, or pose other risks to your health. It is best to follow the guidance provided by your
healthcare professional.
If you miss a dose of ADAKVEO 10mg/ml, take it as soon as you remember. However, if it is close
to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing
schedule. Do not take a double dose to make up for a missed one unless advised by your healthcare provider.
No, do not stop taking ADAKVEO 10mg/ml without consulting your healthcare provider, even if your
symptoms improve. It is important to complete the full course of treatment as prescribed. Stopping
the medication prematurely may lead to a relapse or incomplete resolution of the condition. If you
have concerns about the duration of treatment, consult your healthcare provider for guidance.
It is important to consult your healthcare provider before taking ADAKVEO 10mg/ml if you are
pregnant or breastfeeding. They will be able to assess the potential risks and benefits based on your
specific situation. Please note that the safety and suitability of ADAKVEO 10mg/ml during pregnancy
or breastfeeding may depend on the active substance [Active Substance], concentration 10mg/ml,
and the specific recommendations of NOVARTIS PHARMACEUTICALS CORPORATION.
The effects of ADAKVEO 10mg/ml on your ability to drive or operate machinery can vary depending on
the active substance [Active Substance], concentration 10mg/ml, and individual factors.
Some medications may cause drowsiness, dizziness, or other side effects that can impair your judgment
or coordination. It is important to read the medication label or consult your healthcare provider to
understand any potential effects on your ability to perform tasks that require alertness.
The instructions for taking ADAKVEO 10mg/ml with or without food may vary depending on the medication
and the recommendations of NOVARTIS PHARMACEUTICALS CORPORATION. Some medications may be more effective when taken with
food to enhance absorption or reduce stomach irritation, while others may need to be taken on an empty
stomach for optimal absorption. Read the medication label or consult your healthcare provider for specific instructions.
The use of ADAKVEO 10mg/ml in children or elderly individuals may depend on various factors, including
the specific medication, type Sterile Concentrate Solution for infusion, and the recommendations of NOVARTIS PHARMACEUTICALS CORPORATION. Some
medications may have specific dosing instructions or precautions for these age groups. Consult your
healthcare provider or read the medication label for information regarding the safe and appropriate use
of ADAKVEO 10mg/ml in children or elderly individuals.
Dwaey
All medical information published on the Dwaey website aims to increase medical awareness and health education among users. However, it is not a substitute for professional medical advice. Always consult with a specialist doctor. We strongly advise against using any information or medicine found on the site without referring to your healthcare provider.
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