ADACEL-POLIO Suspension for injection in prefilled syringe

What is ADACEL-POLIO

ADACEL-POLIO is a combination vaccine formulated to provide active booster immunization against four serious diseases: Diphtheria: Caused by Corynebacterium diphtheriae, leading to respiratory issues and potential heart and nerve damage. Tetanus: Caused by Clostridium tetani, leading to muscle stiffness and spasms. Pertussis (Whooping Cough): Caused by Bordetella pertussis, leading to severe coughing spells. Poliomyelitis (Polio): Caused by poliovirus, leading to paralysis and muscle weakness. ADACEL-POLIO is approved for use in individuals aged 4 years and older as a single-dose booster vaccine. It is particularly recommended for those who have previously completed a primary vaccination series against these diseases. mims.com

How to use ADACEL-POLIO

Administration Guidelines: Dosage: A single 0.5 mL dose administered intramuscularly. Injection Site: Preferably the deltoid muscle of the upper arm. Booster Timing: For children aged 4 years and older, adolescents, and adults: Administer as a booster dose following the completion of the primary vaccination series. For wound management: Can be used as a tetanus prophylaxis in individuals with wounds at risk of tetanus infection. medbroadcast.com mims.com Co-administration with Other Vaccines: ADACEL-POLIO can be administered concurrently with other vaccines, using separate syringes and injection sites.

Mode of Action ADACEL-POLIO

ADACEL-POLIO stimulates the body's immune system to produce antibodies against the toxins and pathogens responsible for diphtheria, tetanus, pertussis, and poliomyelitis. Components and Their Functions: Diphtheria Toxoid: Induces immunity against diphtheria toxin. Tetanus Toxoid: Induces immunity against tetanus toxin. Acellular Pertussis Antigens: Pertussis Toxoid (PT): Neutralizes the main toxin produced by B. pertussis. Filamentous Haemagglutinin (FHA): Prevents bacterial adhesion to respiratory epithelial cells. Pertactin (PRN): Aids in bacterial adhesion and invasion. Fimbriae Types 2 and 3 (FIM): Enhance bacterial attachment to host cells. Inactivated Poliovirus Types 1, 2, and 3: Induce immunity against poliovirus strains responsible for poliomyelitis. By introducing these antigens, ADACEL-POLIO primes the immune system to recognize and combat these pathogens upon future exposures.

ADACEL-POLIO Interactions ADACEL-POLIO

Drug Interactions: No significant drug interactions have been reported with ADACEL-POLIO. However, immunosuppressive therapies may reduce the vaccine's effectiveness. mims.com Disease Interactions: Individuals with the following conditions should consult healthcare providers before vaccination: Neurologic Disorders: History of encephalopathy not attributable to another identifiable cause within 7 days of a previous pertussis-containing vaccine. Immunodeficiency: May result in a diminished immune response to the vaccine.

Dosage of ADACEL-POLIO

Standard Dosage: A single 0.5 mL intramuscular injection. Booster Recommendations: Children (≥4 years), Adolescents, and Adults: Administer as a booster dose following the completion of the primary vaccination series against diphtheria, tetanus, pertussis, and poliomyelitis. mims.com Note: The safety and efficacy of ADACEL-POLIO in individuals under 4 years have not been established.

Possible side effects of ADACEL-POLIO

Common Side Effects: Local Reactions: Pain, redness, or swelling at the injection site. Systemic Reactions: Fever. Headache. Fatigue. Gastrointestinal symptoms such as nausea, vomiting, or diarrhea. Less Common Side Effects: Body aches. Mild fever. Diarrhea. Tiredness. mesvaccins.net +2 medicine.com +2 medsinfo.com.au +2 medbroadcast.com Rare but Serious Side Effects: Anaphylaxis (a severe allergic reaction). Guillain-Barré Syndrome. Encephalopathy. Note: Any unusual or severe symptoms following vaccination should be reported to a healthcare provider immediately.

ADACEL-POLIO Contraindications ADACEL-POLIO

Absolute Contraindications: Severe allergic reaction (e.g., anaphylaxis) to any component of ADACEL-POLIO or following a previous dose of a diphtheria, tetanus, pertussis, or poliomyelitis-containing vaccine. Encephalopathy within 7 days of a previous pertussis-containing vaccine not attributable to another identifiable cause. Precautions: Progressive or unstable neurologic disorders, uncontrolled seizures, or progressive encephalopathy. Moderate or severe acute illness with or without fever (vaccination should be postponed until recovery). mims.com

Storage of ADACEL-POLIO

Storage Conditions: Temperature: Store refrigerated at 2°C to 8°C (36°F to 46°F). Do Not Freeze: Freezing destroys the vaccine's potency. Light Protection: Keep the vaccine in its original packaging to protect from light. Handling Instructions: If the vaccine has been frozen, it should be discarded. Before administration, visually inspect the vaccine for particulate matter and discoloration.