ADACEL Suspension for injection

What is ADACEL

ADACEL is a combination vaccine formulated to provide active booster immunization against three serious bacterial infections: fda.gov +3 sanofi.com +3 leg.state.nv.us +3 Tetanus: Caused by Clostridium tetani, leading to painful muscle stiffness and spasms. Diphtheria: Caused by Corynebacterium diphtheriae, affecting the throat and potentially leading to heart and nerve damage. Pertussis (Whooping Cough): Caused by Bordetella pertussis, leading to severe coughing spells that can interfere with breathing. verywellfamily.com ADACEL is approved for use in individuals aged 10 through 64 years as a single-dose booster vaccine. It is also recommended during the third trimester of pregnancy to protect newborns from pertussis in their early months of life.

How to use ADACEL

Administration Guidelines: Dosage: A single 0.5 mL dose administered intramuscularly. Injection Site: Preferably the deltoid muscle of the upper arm. Booster Timing: For adolescents and adults: Administer at least 5 years after the last dose of DTaP or Td vaccine. For pregnant women: Administer during the third trimester (preferably between 27 and 36 weeks gestation). nmsincusa.com drugs.com Co-administration with Other Vaccines: ADACEL can be administered concurrently with other vaccines, using separate syringes and injection sites. cdc.gov

Mode of Action ADACEL

ADACEL stimulates the body's immune system to produce antibodies against the toxins produced by the bacteria responsible for tetanus, diphtheria, and pertussis. medsafe.govt.nz +11 sanofi.com +11 drugs.com +11 Components and Their Functions: Tetanus Toxoid: Induces immunity against tetanus toxin. Diphtheria Toxoid: Induces immunity against diphtheria toxin. Acellular Pertussis Antigens: Pertussis Toxin (PT): Neutralizes the main toxin produced by B. pertussis. Filamentous Hemagglutinin (FHA): Prevents bacterial adhesion to respiratory epithelial cells. Pertactin (PRN): Aids in bacterial adhesion and invasion. Fimbriae Types 2 and 3 (FIM): Enhance bacterial attachment to host cells. By introducing these antigens, ADACEL primes the immune system to recognize and combat these pathogens upon future exposures.

ADACEL Interactions ADACEL

Drug Interactions: No significant drug interactions have been reported with ADACEL. However, immunosuppressive therapies may reduce the vaccine's effectiveness. Disease Interactions: Individuals with the following conditions should consult healthcare providers before vaccination: Neurologic Disorders: History of encephalopathy not attributable to another identifiable cause within 7 days of a previous pertussis-containing vaccine. Immunodeficiency: May result in a diminished immune response to the vaccine. empr.com

Dosage of ADACEL

Standard Dosage: A single 0.5 mL intramuscular injection. nmsincusa.com Booster Recommendations: Adolescents and Adults (10–64 years): Administer at least 5 years after the last dose of DTaP or Td vaccine. Pregnant Women: Administer during each pregnancy, preferably between 27 and 36 weeks gestation, to protect the newborn from pertussis. cdc.gov +2 drugs.com +2 nmsincusa.com +2 verywellfamily.com Note: The safety and efficacy of ADACEL in individuals under 10 years or over 64 years have not been established. drugs.com +2 fda.gov +2 medicomart.com +2

Possible side effects of ADACEL

Common Side Effects: Local Reactions: Pain, redness, or swelling at the injection site. Systemic Reactions: Fever. Headache. Fatigue. Gastrointestinal symptoms such as nausea, vomiting, or diarrhea. cdc.gov Less Common Side Effects: Body aches. Mild fever. Diarrhea. Tiredness. drugs.com cdc.gov +1 drugs.com +1 Rare but Serious Side Effects: Anaphylaxis (a severe allergic reaction). Guillain-Barré Syndrome. Encephalopathy. merckmanuals.com +1 empr.com +1 Note: Any unusual or severe symptoms following vaccination should be reported to a healthcare provider immediately.

ADACEL Contraindications ADACEL

Absolute Contraindications: Severe allergic reaction (e.g., anaphylaxis) to any component of ADACEL or following a previous dose of a tetanus, diphtheria, or pertussis-containing vaccine. Encephalopathy within 7 days of a previous pertussis-containing vaccine not attributable to another identifiable cause. bccdc.ca +1 medicomart.com +1 empr.com Precautions: Progressive or unstable neurologic disorders, uncontrolled seizures, or progressive encephalopathy. Moderate or severe acute illness with or without fever (vaccination should be postponed until recovery). merckmanuals.com

Storage of ADACEL

Storage Conditions: Temperature: Store refrigerated at 2°C to 8°C (36°F to 46°F). Do Not Freeze: Freezing destroys the vaccine's potency. Light Protection: Keep the vaccine in its original packaging to protect from light. nps.org.au +4 cdc.gov +4 fda.gov +4 news-medical.net +1 nps.org.au +1 medicines.org.uk Handling Instructions: If the vaccine has been frozen, it should be discarded. Before administration, visually inspect the vaccine for particulate matter and discoloration. medicines.org.uk