ACTOS 30mg Tablets

What is ACTOS 30mg

ACTOS 30mg is an oral tablet containing pioglitazone hydrochloride, a medication used to manage blood sugar levels in adults with type 2 diabetes mellitus. It belongs to the thiazolidinedione (TZD) class of drugs and is typically prescribed when diet, exercise, and other medications do not provide adequate glycemic control.

• Generic Name: Pioglitazone hydrochloride
• Form: Oral tablet
• Strength: 30 mg
• Packaging: 30 tablets per plastic bottle

ACTOS enhances the body's sensitivity to insulin, thereby improving blood sugar control. It is not intended for the treatment of type 1 diabetes or diabetic ketoacidosis.

How to use ACTOS 30mg

To achieve optimal results with ACTOS 30mg, adhere to the following guidelines:

• Dosage: Take one 30 mg tablet orally once daily.
• Timing: Can be taken with or without food.
• Consistency: Take the medication at the same time each day to maintain steady blood levels.
• Missed Dose: If you miss a dose, take it as soon as you remember. If it's close to your next dose, skip the missed one. Do not double up.
• Monitoring: Regularly check your blood sugar levels as directed by your healthcare provider.
• Medical Appointments: Attend all scheduled appointments for blood tests and assessments to monitor your response to the medication.

Always follow your doctor's instructions and consult them before making any changes to your medication regimen.

Mode of Action ACTOS 30mg

ACTOS 30mg functions by enhancing the body's sensitivity to insulin, which helps lower blood glucose levels. Its mechanism involves:

• PPARγ Activation: Pioglitazone activates peroxisome proliferator-activated receptor gamma (PPARγ), a nuclear receptor that regulates gene expression involved in glucose and lipid metabolism.
• Improved Insulin Sensitivity: Activation of PPARγ increases insulin sensitivity in adipose tissue, skeletal muscle, and the liver, facilitating better glucose uptake and utilization.
• Reduced Hepatic Glucose Production: Decreases the amount of glucose produced by the liver, contributing to lower blood sugar levels.
• Lipid Profile Improvement: May lead to favorable changes in lipid profiles, such as increased HDL cholesterol and decreased triglycerides.

These combined effects help in achieving better glycemic control in individuals with type 2 diabetes.

ACTOS 30mg Interactions ACTOS 30mg

ACTOS 30mg can interact with various medications, which may affect its efficacy or increase the risk of adverse effects. Notable interactions include:

• Gemfibrozil: A strong CYP2C8 inhibitor that can increase pioglitazone levels, necessitating a maximum ACTOS dose of 15 mg daily.
• Rifampin: A CYP2C8 inducer that may decrease pioglitazone levels, potentially reducing its effectiveness.
• Insulin and Sulfonylureas: Concurrent use may increase the risk of hypoglycemia; dose adjustments may be required.
• Clopidogrel: May increase pioglitazone levels, raising the risk of side effects such as hypoglycemia and fluid retention.
• Oral Contraceptives: Pioglitazone may reduce the effectiveness of hormonal contraceptives; alternative methods should be considered.
• Alcohol: Excessive consumption can affect blood sugar control and increase the risk of hypoglycemia.

Always inform your healthcare provider about all medications and supplements you are taking to avoid potential interactions.

Dosage of ACTOS 30mg

The dosage of ACTOS 30mg should be individualized based on patient needs and response:

• Starting Dose: 15 mg or 30 mg once daily.
• Titration: Dosage may be increased in 15 mg increments up to a maximum of 45 mg once daily, based on glycemic response.
• Combination Therapy: When used with insulin or sulfonylureas, monitor for hypoglycemia and adjust doses accordingly.
• Renal Impairment: No dosage adjustment is necessary, but use with caution.
• Hepatic Impairment: Not recommended in patients with active liver disease or elevated liver enzymes.

Regular monitoring of blood glucose and HbA1c levels is essential to assess the effectiveness of the therapy and make necessary adjustments.

Possible side effects of ACTOS 30mg

While ACTOS 30mg is generally well-tolerated, some individuals may experience side effects:

• Common: Weight gain, edema (swelling), headache, and upper respiratory tract infections.
• Serious: Heart failure, especially in patients with pre-existing cardiac conditions; bladder cancer risk; liver enzyme elevations; and bone fractures, particularly in women.
• Hypoglycemia: More likely when used in combination with insulin or sulfonylureas.
• Visual Disturbances: Changes in vision due to fluid retention in the eye.

If you experience any severe or persistent side effects, contact your healthcare provider immediately.

ACTOS 30mg Contraindications ACTOS 30mg

ACTOS 30mg should not be used in the following situations:

• Heart Failure: Contraindicated in patients with NYHA Class III or IV heart failure.
• Bladder Cancer: Not recommended for patients with active bladder cancer or a history of the disease.
• Liver Disease: Avoid in patients with active liver disease or elevated liver enzymes.
• Diabetic Ketoacidosis: Not suitable for treating this acute condition.
• Hypersensitivity: Contraindicated in individuals with known hypersensitivity to pioglitazone or any component of the product.

Always consult your healthcare provider to determine if ACTOS 30mg is appropriate for your condition.

Storage of ACTOS 30mg

Proper storage of ACTOS 30mg ensures its effectiveness and safety:

• Temperature: Store at room temperature, between 20°C to 25°C (68°F to 77°F).
• Environment: Keep away from moisture, heat, and direct sunlight.
• Container: Store in the original container with the lid tightly closed.
• Keep Out of Reach: Ensure that children and pets do not have access to the medication.
• Disposal: Do not use after the expiration date. Dispose of unused medication properly, following local regulations or pharmacy guidelines.

Do not store ACTOS 30mg in the bathroom or other damp areas to prevent degradation.