ACTILOR 5mg Tablets/Film-coated

What is ACTILOR 5mg

ACTILOR 5mg tablets are a pharmaceutical preparation containing Desloratadine as the active ingredient. Desloratadine is a second-generation antihistamine used primarily to treat allergic conditions by blocking the effects of histamine, a chemical released during allergic reactions.

• Formulated as film-coated tablets for ease of swallowing and stability.
• Supplied in packs of 30 tablets (three blisters of 10 tablets each), designed for adults and adolescents.
• Commonly indicated for symptomatic relief of seasonal allergic rhinitis (hay fever) including sneezing, runny nose, nasal congestion, and itchy or watery eyes.
• Also effective for chronic idiopathic urticaria (hives) by reducing itching and rash.
• Known for minimal sedation effects compared to first-generation antihistamines due to its selective peripheral action.

Overall, ACTILOR 5mg tablets provide effective, once-daily relief from allergy symptoms with a favorable safety profile.

How to use ACTILOR 5mg

Proper use of ACTILOR 5mg tablets ensures optimal symptom control and safety. Consider the following guidelines:

• Dosage: Typically, one tablet (5mg) once daily for adults and adolescents aged 12 years and older.
• Administration: Swallow the tablet whole with water; it can be taken with or without food.
• Consistency: Take the tablet at the same time each day to maintain steady medication levels in the body.
• Missed Dose: If a dose is missed, take it as soon as remembered unless it is close to the next dose. Do not double the dose.
• Duration: Follow the healthcare provider’s instructions regarding the length of treatment, even if symptoms improve earlier.
• Precautions: Inform your doctor if you are pregnant, breastfeeding, or have liver/kidney issues prior to starting.
• Do Not Share: Use only as prescribed for you; sharing medication can lead to inappropriate dosing or adverse effects.

Adhering to these instructions will maximize treatment effectiveness and minimize potential risks.

Mode of Action ACTILOR 5mg

The effectiveness of ACTILOR 5mg tablets is due to the pharmacological activity of desloratadine, which works by:

• Histamine Blockade: Desloratadine selectively blocks peripheral H1 histamine receptors, preventing histamine from binding and causing allergic symptoms such as itching, swelling, and increased mucus production.
• Peripheral Action: Minimal penetration across the blood-brain barrier reduces sedation and CNS side effects common to older antihistamines.
• Anti-inflammatory Effects: Besides histamine receptor blockade, desloratadine may reduce the release of other inflammatory mediators from mast cells, enhancing symptom relief.
• Long Half-life: Its long duration allows once-daily dosing with sustained antihistaminic effects over 24 hours.

By inhibiting histamine’s action at the receptor level, ACTILOR reduces the hallmark symptoms of allergic reactions, improving patient comfort.

ACTILOR 5mg Interactions ACTILOR 5mg

Drug interactions can alter the effectiveness or safety of ACTILOR 5mg. Important interaction considerations include:

• CYP3A4 and CYP2D6 Inhibitors: Drugs such as ketoconazole, erythromycin, cimetidine, and ritonavir can inhibit desloratadine metabolism, possibly increasing its plasma levels and side effects.
• Alcohol and CNS Depressants: Although desloratadine is non-sedating, concomitant use with alcohol or sedatives may enhance CNS depression.
• Other Antihistamines: Combining with other H1 antihistamines may increase side effects and is generally not recommended.
• MAO Inhibitors: No significant direct interaction noted, but caution advised with CNS-acting agents.
• Herbal Supplements and Over-the-Counter Medications: Always disclose all medications to your healthcare provider to evaluate potential interactions.

Careful monitoring and communication with healthcare professionals help minimize risks related to drug interactions.

Dosage of ACTILOR 5mg

The appropriate dosage of ACTILOR 5mg tablets depends on the patient's age and medical condition. Standard dosing guidelines include:

• Adults and Adolescents (≥12 years): One 5mg tablet once daily, orally.
• Children under 12 years: ACTILOR tablets are not recommended; syrup form preferred.
• Elderly Patients: Typically, standard dosing is appropriate, but monitor for tolerability.
• Patients with Hepatic or Renal Impairment: Dose adjustments may be necessary; consult a healthcare provider.
• Duration of Therapy: Should be guided by the physician based on clinical response; long-term use requires periodic evaluation.

Strict adherence to prescribed dosage maximizes benefits and limits side effects.

Possible side effects of ACTILOR 5mg

ACTILOR 5mg tablets are generally well tolerated, but some patients may experience adverse effects:

• Common Side Effects: Headache, fatigue, dry mouth, and mild dizziness.
• Gastrointestinal Issues: Nausea, abdominal pain, and diarrhea can occasionally occur.
• CNS Effects: Rare reports of sedation or nervousness.
• Allergic Reactions: Although rare, symptoms such as rash, itching, swelling, or difficulty breathing require immediate medical attention.
• Other Rare Effects: Palpitations or sleep disturbances.

If you experience severe or persistent side effects, consult your healthcare provider promptly for guidance.

ACTILOR 5mg Contraindications ACTILOR 5mg

The use of ACTILOR 5mg tablets is contraindicated in the following cases:

• Known hypersensitivity to desloratadine, loratadine, or any tablet components.
• Severe hepatic impairment due to altered drug metabolism risks.
• Children under 12 years for the tablet form (syrup recommended instead).
• Pregnant or breastfeeding women should use only if clearly indicated and under medical supervision.
• Patients with any history of severe allergic reactions to antihistamines.

Always consult your healthcare provider before starting treatment to rule out contraindications.

Storage of ACTILOR 5mg

Proper storage is essential to maintain the potency and safety of ACTILOR 5mg tablets:

• Store at room temperature between 15°C and 30°C (59°F to 86°F).
• Keep tablets in their original blister packaging to protect from moisture and light exposure.
• Avoid storing in humid places like bathrooms.
• Keep out of reach of children to prevent accidental ingestion.
• Do not use tablets past the expiration date printed on the package.
• Dispose of expired or unused medication according to local regulations or pharmacy guidelines.

Following these storage recommendations ensures that the medication remains effective and safe for use throughout its shelf life.