ACTIFED DM Syrup/Cough Linctus

What is ACTIFED DM

ACTIFED DM is a combination syrup formulated to relieve symptoms associated with upper respiratory tract infections, including dry cough, nasal congestion, and allergic reactions. It contains three active ingredients:

• Pseudoephedrine Hydrochloride: A decongestant that narrows the blood vessels in the nasal passages, reducing swelling and congestion.
• Triprolidine Hydrochloride: An antihistamine that blocks histamine receptors, alleviating allergic symptoms like sneezing and runny nose.
• Dextromethorphan Hydrobromide: A cough suppressant that acts on the brain's cough center to reduce the urge to cough.

This combination makes ACTIFED DM effective in treating:

• Dry, non-productive coughs
• Nasal and sinus congestion
• Allergic rhinitis symptoms
• Common cold and flu-related symptoms

How to use ACTIFED DM

Proper usage of ACTIFED DM ensures maximum effectiveness and minimizes potential side effects.

• Administration: Oral – measure the syrup using a calibrated spoon or measuring cup.
• Dosage: Follow the prescribed dosage by your healthcare provider. Do not exceed the recommended amount.
• Timing: Typically taken every 4 to 6 hours as needed. Do not take more than 4 doses in 24 hours.
• With or without food: Can be taken with or without food. Taking with food may reduce stomach upset.

Important Usage Instructions:

• Shake the bottle well before each use.
• Use the provided measuring device for accurate dosing.
• Avoid consuming alcohol or other central nervous system depressants while taking this medication.
• Do not operate heavy machinery or drive until you know how the medication affects you, as it may cause drowsiness.

Missed Dose: If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed one. Do not double the dose to catch up.

Mode of Action ACTIFED DM

ACTIFED DM works through the synergistic action of its three components:

• Pseudoephedrine Hydrochloride:
  • Acts on alpha-adrenergic receptors in the nasal mucosa.
  • Causes vasoconstriction, reducing nasal congestion and sinus swelling.
• Triprolidine Hydrochloride:
  • Blocks H1 histamine receptors.
  • Alleviates allergic symptoms like sneezing, itching, and runny nose.
• Dextromethorphan Hydrobromide:
  • Suppresses the cough reflex by acting on the medullary cough center in the brain.
  • Reduces the frequency and intensity of dry, non-productive coughs.

By targeting different pathways, ACTIFED DM effectively relieves multiple symptoms associated with upper respiratory tract infections.

ACTIFED DM Interactions ACTIFED DM

ACTIFED DM may interact with other medications, leading to increased side effects or reduced effectiveness. Inform your healthcare provider about all the medications and supplements you are taking.

• Monoamine Oxidase Inhibitors (MAOIs): Concurrent use can lead to hypertensive crises. Avoid using ACTIFED DM within 14 days of MAOI therapy.
• Central Nervous System Depressants: Combining with alcohol, sedatives, or tranquilizers can enhance drowsiness and respiratory depression.
• Antihypertensive Agents: Pseudoephedrine may reduce the effectiveness of medications used to lower blood pressure.
• Other Sympathomimetic Agents: Concurrent use can increase the risk of cardiovascular side effects.
• Selective Serotonin Reuptake Inhibitors (SSRIs): May increase the risk of serotonin syndrome when combined with dextromethorphan.

Always consult your healthcare provider before starting or stopping any medication while using ACTIFED DM.

Dosage of ACTIFED DM

The dosage of ACTIFED DM depends on the patient's age, medical condition, and response to treatment. Always follow your healthcare provider's instructions.

• Adults and Children over 12 years: 10 ml (2 teaspoons) every 4 to 6 hours. Do not exceed 4 doses (40 ml) in 24 hours.
• Children 6 to 12 years: 5 ml (1 teaspoon) every 4 to 6 hours. Maximum of 4 doses (20 ml) in 24 hours.
• Children 2 to 6 years: 2.5 ml (½ teaspoon) every 4 to 6 hours. Maximum of 4 doses (10 ml) in 24 hours. Use only under medical supervision.
• Children under 2 years: Not recommended.

Special Populations:

• Elderly: Use with caution. Dosage may need adjustment due to increased sensitivity to side effects.
• Renal or Hepatic Impairment: Dosage adjustments may be necessary. Consult your healthcare provider.

Overdose: In case of overdose, seek immediate medical attention. Symptoms may include restlessness, confusion, hallucinations, and respiratory depression.

Possible side effects of ACTIFED DM

While ACTIFED DM is generally well-tolerated, some individuals may experience side effects. If any of these persist or worsen, contact your healthcare provider.

• Common Side Effects:
  • Drowsiness or dizziness
  • Dry mouth, nose, or throat
  • Nausea or upset stomach
  • Constipation
• Less Common Side Effects:
  • Headache
  • Nervousness or restlessness
  • Blurred vision
  • Difficulty sleeping
• Serious Side Effects (Seek immediate medical attention):
  • Fast or irregular heartbeat
  • Severe dizziness or fainting
  • Hallucinations or confusion
  • Seizures
  • Allergic reactions: rash, itching, swelling, severe dizziness, trouble breathing

Report any unusual or severe side effects to your healthcare provider promptly.

ACTIFED DM Contraindications ACTIFED DM

ACTIFED DM should not be used in certain individuals. Contraindications include:

• Allergy: Known hypersensitivity to pseudoephedrine, triprolidine, dextromethorphan, or any component of the formulation.
• MAOI Therapy: Concurrent use or within 14 days of stopping MAOIs due to risk of hypertensive crisis.
• Severe Hypertension or Coronary Artery Disease: Pseudoephedrine may exacerbate these conditions.
• Glaucoma: Triprolidine may increase intraocular pressure.
• Urinary Retention: Particularly in patients with prostatic hypertrophy.
• Children under 2 years: Safety and efficacy not established.
• Pregnancy and Lactation: Use only if clearly needed and prescribed by a healthcare provider.

Consult your healthcare provider before using ACTIFED DM if you have any of the above conditions.

Storage of ACTIFED DM

Proper storage of ACTIFED DM ensures its effectiveness and safety.

• Temperature: Store at room temperature, between 15°C to 30°C (59°F to 86°F).
• Environment: Keep away from moisture, heat, and direct sunlight.
• Container: Store in the original, tightly closed container.
• Keep Out of Reach of Children: To prevent accidental ingestion.
• Do Not Freeze: Freezing may alter the effectiveness of the syrup.
• Expiration: Do not use after the expiration date printed on the label.
• Disposal: Dispose of unused or expired medication according to local regulations. Do not pour down the drain or flush.

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