ACTIFED Tablets

What is ACTIFED

ACTIFED is a combination medication used to relieve symptoms associated with the common cold, hay fever, and upper respiratory allergies. It contains two active ingredients:

• Pseudoephedrine Hydrochloride: A nasal decongestant that works by narrowing the blood vessels in the nasal passages, reducing swelling and congestion.
• Triprolidine Hydrochloride: An antihistamine that blocks the action of histamine, a substance in the body that causes allergic symptoms like sneezing, runny nose, and watery eyes.

ACTIFED is typically formulated in tablet form and is available in a 12-tablet blister pack. It is an over-the-counter (OTC) medication in many countries, though it may be restricted due to the pseudoephedrine component, which is regulated in some regions.

This medicine is primarily indicated for:

• Nasal congestion
• Sneezing
• Runny nose
• Watery eyes
• Itchy throat or nose

ACTIFED offers temporary relief from these symptoms but does not treat the underlying cause of the infection or allergy. It's suitable for short-term use under the direction of a healthcare provider or as per labeled instructions.

How to use ACTIFED

ACTIFED should be used according to the instructions provided on the packaging or as directed by a healthcare professional. Misuse or overuse can increase the risk of side effects and reduce effectiveness.

• Dosage form: Oral tablets in a 12-tablet blister pack.
• Administration: Swallow the tablet whole with a glass of water. Do not crush or chew the tablet.
• Recommended adult dosage: Typically, 1 tablet every 4–6 hours, not exceeding 4 doses (4 tablets) in 24 hours.
• Children: Not recommended for children under 12 years unless specifically prescribed.
• Duration: Should not be used for more than 7 consecutive days without medical supervision.

Important usage tips:

• Do not exceed the recommended dose.
• If a dose is missed, take it as soon as remembered, unless it is almost time for the next dose. Do not double up.
• Do not take with other cold or allergy medications unless instructed by a doctor.
• Avoid alcohol and sedatives while using ACTIFED, as they may enhance drowsiness.

Always read the label before use, and consult a healthcare provider if symptoms persist or worsen.

Mode of Action ACTIFED

ACTIFED works through the complementary actions of its two active ingredients—pseudoephedrine and triprolidine—to relieve multiple symptoms of colds and allergies.

• Pseudoephedrine Hydrochloride:
  • A sympathomimetic amine that acts as a decongestant.
  • Stimulates α-adrenergic receptors in the respiratory tract mucosa.
  • This leads to vasoconstriction (narrowing of blood vessels), reducing nasal congestion and sinus pressure.
• Triprolidine Hydrochloride:
  • A first-generation antihistamine belonging to the alkylamine class.
  • Blocks H1 histamine receptors in respiratory and vascular tissues.
  • This action reduces symptoms like sneezing, watery eyes, and runny nose by preventing the histamine response triggered by allergens.

In combination, these agents provide a multi-symptom relief by targeting both nasal obstruction and allergic manifestations. The onset of action usually occurs within 30 minutes, with symptom control lasting for 4–6 hours.

ACTIFED Interactions ACTIFED

ACTIFED can interact with several types of medications. These interactions can either enhance side effects or reduce the efficacy of one or more of the drugs involved.

Major drug interactions include:

• Monoamine oxidase inhibitors (MAOIs): Such as phenelzine or tranylcypromine. Concurrent use may cause hypertensive crises. Avoid ACTIFED if MAOIs were used in the last 14 days.
• Other decongestants or antihistamines: Increases the risk of additive side effects like insomnia, dry mouth, or dizziness.
• Beta-blockers (e.g., propranolol): May increase the risk of high blood pressure when taken with pseudoephedrine.
• Antidepressants (tricyclics): May potentiate the pressor effects of pseudoephedrine.
• Alcohol or CNS depressants: Can exacerbate sedation from triprolidine.

Herbal and OTC interactions:

• Herbal products with sedative properties (e.g., valerian root) may intensify drowsiness.
• OTC cough/cold medications may lead to accidental duplication of active ingredients.

It is crucial to inform your doctor or pharmacist about all medications and supplements you are currently taking before starting ACTIFED.

Dosage of ACTIFED

The dosage of ACTIFED should be individualized based on patient age, health status, and symptom severity. Below is a general guideline:

• Adults and children over 12 years:
  • 1 tablet every 4 to 6 hours as needed.
  • Do not exceed 4 tablets in 24 hours.
• Children under 12 years:
  • Use not recommended unless directed by a healthcare professional.

Special populations:

• Elderly: Use with caution due to higher sensitivity to antihistamines.
• Renal impairment: Dosage adjustment may be necessary due to pseudoephedrine accumulation.

Administration tips:

• Take with or without food.
• Swallow tablets whole with water.
• Do not chew or crush.

Always follow the dosage instructions on the label or as prescribed. Do not self-medicate beyond the recommended duration.

Possible side effects of ACTIFED

Like all medications, ACTIFED can cause side effects, although not everyone experiences them. Most are mild and transient but some may require medical attention.

Common side effects:

• Drowsiness or sedation
• Dry mouth, nose, or throat
• Headache
• Nervousness or restlessness
• Insomnia
• Increased heart rate (tachycardia)

Less common or serious side effects:

• Allergic reactions such as rash, itching, or swelling
• High blood pressure
• Blurred vision
• Urinary retention, particularly in men with prostate enlargement
• Hallucinations (rare and usually dose-related)

Seek immediate medical attention if:

• You experience difficulty breathing, chest pain, or facial swelling
• There are signs of a severe allergic reaction (anaphylaxis)

Report any unusual or persistent symptoms to a healthcare provider promptly.

ACTIFED Contraindications ACTIFED

ACTIFED is contraindicated in the following situations and should not be used unless approved by a healthcare provider:

• Hypersensitivity: Known allergy to pseudoephedrine, triprolidine, or any excipients in the tablet.
• Severe hypertension or coronary artery disease: Pseudoephedrine may worsen cardiovascular symptoms.
• Concurrent or recent use of MAO inhibitors: Must be avoided within 14 days due to risk of hypertensive crisis.
• Narrow-angle glaucoma: Triprolidine may exacerbate intraocular pressure.
• Severe urinary retention: Particularly in patients with prostatic hypertrophy.

Use with caution:

• In elderly patients prone to anticholinergic side effects.
• In individuals with diabetes, hyperthyroidism, or epilepsy.
• During pregnancy and breastfeeding (consult physician).

Always consult a healthcare provider if you have underlying medical conditions or are on long-term medications before using ACTIFED.

Storage of ACTIFED

Proper storage of ACTIFED helps maintain its effectiveness and prevents degradation or contamination.

• Temperature: Store at room temperature between 20°C to 25°C (68°F to 77°F).
• Keep away from:
  • Heat sources and direct sunlight
  • Moisture (avoid storing in bathrooms)
• Packaging: Keep the tablets in their original 12-tablet blister pack until use to protect them from air and moisture.
• Child safety: Store out of the reach and sight of children.
• Expiry: Do not use after the expiration date printed on the packaging.

Dispose of unused or expired medication according to local regulations or return to a pharmacy. Do not flush down the toilet unless specifically instructed.