HUMULIN PROFILE-50 100 IU/ml Injection

What is HUMULIN PROFILE-50 100 IU/ml

HUMULIN PROFILE-50 100 IU/ml is a biphasic insulin preparation used for managing blood glucose levels in patients with diabetes mellitus. It combines two forms of insulin: Isophane insulin (NPH) and Regular insulin (soluble insulin). This combination consists of 50% regular insulin and 50% isophane insulin, offering both rapid and long-acting effects to provide better control of blood glucose throughout the day.

• Generic Name: Isophane biphasic insulin (human) (50% regular insulin and 50% isophane insulin)
• Form: Injection
• Concentration: 100 IU/ml
• Packaging: 10 ml vial
• Indication: Used to treat both Type 1 and Type 2 diabetes by maintaining blood glucose control.
• Mechanism: Provides rapid action post-meal and long-lasting control for basal insulin requirements.

How to use HUMULIN PROFILE-50 100 IU/ml

Correct administration of HUMULIN PROFILE-50 ensures effective blood glucose control. Follow these steps carefully for proper usage:

1. Preparation: Roll the vial gently between your palms to mix the insulin. Avoid shaking it.
2. Injection Site: Choose an injection site like the abdomen, thigh, or upper arm and clean it with an alcohol swab.
3. Draw the Insulin: Use a sterile syringe to draw the prescribed amount of insulin. Be sure to remove any air bubbles.
4. Inject: Pinch the skin at the injection site, insert the needle at a 90-degree angle, and slowly push the plunger.
5. Post-Injection Care: Dispose of the needle in a sharps container and massage the injection site gently.
6. Timing: Inject the insulin 15–30 minutes before meals, typically twice a day (morning and evening).

Mode of Action HUMULIN PROFILE-50 100 IU/ml

HUMULIN PROFILE-50’s biphasic formulation combines two types of insulin, each working at different rates to regulate blood glucose:

• Regular Insulin (50%): Starts working within 30 minutes, peaks at 2–4 hours, and lasts for 6–8 hours, controlling post-meal glucose spikes.
• Isophane Insulin (50%): Takes 1–2 hours to take effect, peaks at 4–12 hours, and provides a sustained action lasting 12–16 hours for basal glucose control.

This combination provides both rapid action for immediate post-meal glucose control and long-lasting effects for steady blood glucose regulation throughout the day.

HUMULIN PROFILE-50 100 IU/ml Interactions HUMULIN PROFILE-50 100 IU/ml

HUMULIN PROFILE-50 may interact with certain medications, affecting its blood glucose-lowering effects. It's crucial to understand these interactions to manage your insulin therapy effectively:

• Oral Hypoglycemics: Medications like metformin or sulfonylureas can increase insulin effects, raising the risk of hypoglycemia.
• Beta-Blockers: Drugs such as propranolol may mask hypoglycemia symptoms, making it difficult to detect low blood sugar.
• Corticosteroids: Medications like prednisone can raise blood sugar levels, requiring adjustments to insulin dosages.
• Thiazide Diuretics: Drugs like hydrochlorothiazide may increase blood sugar levels, potentially necessitating higher insulin doses.
• Alcohol: Excessive alcohol consumption can increase the risk of hypoglycemia.
• ACE Inhibitors: Medications like enalapril may improve insulin sensitivity, requiring dose adjustments.

It is essential to inform your healthcare provider about all medications you are taking to avoid unwanted interactions.

Dosage of HUMULIN PROFILE-50 100 IU/ml

The dosage of HUMULIN PROFILE-50 is individualized based on factors like body weight, blood glucose levels, and the patient's specific needs. Here are general guidelines:

• Initial Dose: Typically, 0.5 to 1.0 units per kg of body weight per day.
• Frequency: Administered twice daily (morning and evening), typically 15–30 minutes before meals.
• Adjustment: Dosing may be adjusted based on blood glucose monitoring and lifestyle factors.

Patients should monitor blood glucose regularly and consult with a healthcare provider to adjust dosages as needed for optimal control.

Possible side effects of HUMULIN PROFILE-50 100 IU/ml

As with any medication, HUMULIN PROFILE-50 may cause side effects. While not everyone experiences these, common and serious side effects should be carefully monitored:

• Common Side Effects:
  • Hypoglycemia: Symptoms include shaking, sweating, dizziness, confusion, and in severe cases, loss of consciousness.
  • Injection Site Reactions: Pain, redness, or swelling at the injection site.
  • Weight Gain: Some patients may experience weight gain due to improved glucose utilization.
• Serious Side Effects:
  • Insulin Resistance: Over time, some patients may develop resistance, requiring higher doses.
  • Lipodystrophy: Repeated injection at the same site may cause fat tissue changes, leading to lumps or indentations.
  • Severe Hypoglycemia: Rare cases can lead to coma or seizures, requiring immediate medical attention.

HUMULIN PROFILE-50 100 IU/ml Contraindications HUMULIN PROFILE-50 100 IU/ml

There are certain conditions where HUMULIN PROFILE-50 should not be used, or should be used with caution:

• Hypersensitivity to Insulin: Not suitable for individuals allergic to insulin or its components.
• Severe Hypoglycemia: Should not be used during episodes of severe hypoglycemia until blood sugar is corrected.
• Renal and Hepatic Impairment: Patients with severe kidney or liver dysfunction should exercise caution, as insulin metabolism may be altered.
• Pregnancy and Breastfeeding: Generally safe under medical supervision but may require dose adjustments.

Storage of HUMULIN PROFILE-50 100 IU/ml

Proper storage of HUMULIN PROFILE-50 is vital for ensuring its effectiveness:

• Unopened Vials: Store in the refrigerator (2°C to 8°C/36°F to 46°F). Do not freeze.
• Opened Vials: Can be kept at room temperature (<30°C/86°F) for up to 28 days. Do not refrigerate after opening.
• Avoid Heat and Light: Store away from direct sunlight and heat sources.
• Disposal: Dispose of syringes and needles in a proper sharps container after use.