HUMULIN PROFILE-30 100 IU/ml Injection

What is HUMULIN PROFILE-30 100 IU/ml

HUMULIN PROFILE-30 100 IU/ml is a type of insulin medication used for the management of diabetes mellitus, specifically Type 1 and Type 2 diabetes. It is a biphasic insulin formulation, combining both regular insulin (soluble insulin) and isophane insulin in a 30/70 ratio. This combination is designed to offer both immediate and prolonged action to better mimic the natural insulin release in the body.

• Composition: HUMULIN PROFILE-30 contains 30% regular (soluble) insulin and 70% isophane insulin (NPH). The regular insulin provides a rapid onset of action, while the isophane insulin offers a prolonged effect.
• Indications: It is prescribed to control blood sugar levels in patients with diabetes. It is particularly useful for patients who require both rapid and sustained glucose control.
• Form: Available as an injectable solution in a 10ml vial, designed for subcutaneous injection.
• Dosage: The dosage is individualized based on blood glucose monitoring, diet, exercise, and the patient's overall response to insulin therapy.
• Brand Name: HUMULIN PROFILE-30 is a trademark of Eli Lilly and Company, a well-known pharmaceutical manufacturer.

This insulin formulation is typically administered through an injection under the skin (subcutaneously). Depending on the patient’s needs, it may be used once or twice daily, often combined with other insulin forms for comprehensive blood sugar management.

How to use HUMULIN PROFILE-30 100 IU/ml

p>The proper administration of HUMULIN PROFILE-30 is essential to ensure the effective control of blood sugar levels. Below are step-by-step guidelines on how to use this insulin:

• Preparation: Before using the vial, make sure to check for any particles or cloudiness. Humulin Profile-30 should appear milky, and the vial must be gently mixed by rolling it between your hands. Never shake it vigorously, as this could damage the insulin molecules.
• Injection Site: HUMULIN PROFILE-30 is administered via subcutaneous injection. The injection site can be the fatty layer of the skin in areas such as the abdomen, thighs, upper arms, or buttocks. Rotate injection sites to avoid lipodystrophy (fatty tissue buildup or loss).
• Dosage Administration: The dose of insulin will depend on the specific needs of the patient, and should be based on regular blood glucose monitoring. Typically, the insulin is administered one to two times per day.
• Using the Syringe: Use a clean, sterile syringe or insulin pen. Draw the prescribed amount of insulin into the syringe and check for air bubbles before injecting. Ensure the dosage is accurate, and never reuse syringes to avoid infection or inaccurate dosing.
• Timing: The insulin should be administered approximately 30 minutes before meals, allowing for both the rapid and longer-acting components of the insulin to take effect.

If you're unsure about how to inject insulin, consult with a healthcare professional or diabetes educator for a demonstration. Proper training and technique are crucial for the effectiveness of the treatment.

Mode of Action HUMULIN PROFILE-30 100 IU/ml

HUMULIN PROFILE-30 combines two forms of insulin—regular (soluble) insulin and isophane insulin—in a fixed ratio to mimic the body's natural insulin response. Its mode of action can be broken down into the following points:

• Regular (Soluble) Insulin (30%): The regular insulin in HUMULIN PROFILE-30 is rapidly absorbed into the bloodstream, providing a quick reduction in blood glucose levels. It starts acting within 30 minutes and peaks at approximately 2-4 hours, helping to control postprandial (after meal) blood sugar spikes.
• Isophane (NPH) Insulin (70%): The isophane insulin has a slower onset and provides a sustained release of insulin into the bloodstream, helping to maintain blood sugar control for up to 18 hours. This portion of the insulin formulation helps manage basal (background) insulin levels throughout the day and night.
• Combined Effect: The biphasic nature of this insulin helps address both the rapid and prolonged insulin needs of the body. This allows for better overall blood glucose control with a single injection.
• Peak and Duration: The combination results in an intermediate acting insulin that has a peak effect within 2 to 8 hours, depending on the individual’s metabolism and lifestyle. The duration of action can last up to 24 hours, ensuring steady glucose regulation.

This combination therapy helps prevent both hyperglycemia (high blood sugar) and hypoglycemia (low blood sugar), offering a balanced solution for patients with diabetes.

HUMULIN PROFILE-30 100 IU/ml Interactions HUMULIN PROFILE-30 100 IU/ml

• Oral Hypoglycemic Agents: Medications such as sulfonylureas, meglitinides, and biguanides (like metformin) can enhance the blood-glucose-lowering effects of insulin, leading to an increased risk of hypoglycemia.
• Beta-Blockers: Non-selective beta-blockers can mask the symptoms of hypoglycemia, making it difficult for the patient to recognize low blood sugar. Beta-blockers may also potentiate insulin's glucose-lowering effect, increasing the risk of hypoglycemia.
• Corticosteroids: Corticosteroids like prednisone can elevate blood glucose levels and may counteract the blood-sugar-lowering effects of insulin, requiring an adjustment in insulin dosage during use.
• Alcohol: Alcohol can either increase the risk of hypoglycemia (especially if taken without food) or elevate blood sugar levels. Alcohol's effect on insulin may vary depending on the individual's condition and the timing of the consumption.
• Thyroid Hormones: Levothyroxine (thyroid medication) may interfere with insulin therapy, potentially requiring adjustments to insulin dosage to avoid hypoglycemia or hyperglycemia.

It's essential to inform your healthcare provider of all medications you are taking, including over-the-counter drugs and supplements, before starting insulin therapy. Adjustments to your insulin regimen may be needed based on these interactions.

Dosage of HUMULIN PROFILE-30 100 IU/ml

The correct dosage of HUMULIN PROFILE-30 depends on several factors, including the patient’s age, body weight, blood glucose levels, diet, exercise regimen, and overall response to insulin therapy. Typically, the following guidelines are followed:

• Initial Dosage: For patients who have not been using insulin previously, the starting dose usually ranges between 0.3 to 0.5 IU/kg body weight per day. This can be adjusted based on blood glucose levels and the patient’s individual needs.
• Frequency: HUMULIN PROFILE-30 is often administered once or twice daily, with adjustments based on individual blood sugar levels. Some patients may require a higher dosage if they are unable to achieve target glucose levels with a single injection.
• Individual Adjustments: The insulin dose may need to be adjusted depending on meal schedules, physical activity levels, and any changes in body weight or health status. Regular blood glucose monitoring is essential to fine-tune the insulin regimen.
• Injecting Before Meals: Typically, HUMULIN PROFILE-30 is injected 30 minutes before meals. However, the timing can be adjusted based on how your body responds to the insulin.
• Dosage for Children: Pediatric patients may require lower doses. It's crucial to consult a pediatric endocrinologist to determine the proper dose.

Dosage should always be adjusted under the supervision of a healthcare provider to avoid risks of hypoglycemia or hyperglycemia.

Possible side effects of HUMULIN PROFILE-30 100 IU/ml

• Hypoglycemia (Low Blood Sugar): This is the most common side effect and can occur if the insulin dose is too high relative to food intake, physical activity, or if the patient misses a meal. Symptoms include dizziness, sweating, confusion, and trembling.
• Injection Site Reactions: Pain, redness, swelling, or irritation at the injection site may occur. These reactions are typically mild and resolve over time. Rotating injection sites can help reduce these effects.
• Weight Gain: Weight gain may occur in some individuals when using insulin therapy due to improved glucose utilization, although it is not guaranteed for every patient.
• Allergic Reactions: Although rare, some patients may experience severe allergic reactions to insulin, resulting in rash, difficulty breathing, or swelling of the face and throat. Seek emergency medical care if these symptoms occur.
• Edema (Swelling): Fluid retention in the body can sometimes occur, especially in patients with pre-existing heart conditions.
• Hypokalemia: Low potassium levels can occur as a result of insulin therapy, which can cause muscle weakness, fatigue, and abnormal heart rhythms.

While these side effects are possible, they are not guaranteed. It's essential to regularly monitor blood sugar levels and follow the prescribed regimen to minimize risks. In case of severe or persistent side effects, contact a healthcare professional immediately.

HUMULIN PROFILE-30 100 IU/ml Contraindications HUMULIN PROFILE-30 100 IU/ml

There are certain conditions where HUMULIN PROFILE-30 should not be used or should be used with caution. These include:

• Hypersensitivity: Individuals with known hypersensitivity to insulin or any component of HUMULIN PROFILE-30 should avoid this medication. An allergic reaction may result in severe consequences, such as anaphylaxis.
• Hypoglycemia: HUMULIN PROFILE-30 should not be administered to patients who are currently experiencing hypoglycemia, as it could worsen the condition.
• Severe Liver or Kidney Impairment: Patients with severe liver or kidney disease may require dosage adjustments, as insulin action can be affected by organ function. Close monitoring is essential.
• Pregnancy and Breastfeeding: During pregnancy, insulin requirements may change. Although insulin is generally safe during pregnancy, HUMULIN PROFILE-30 should be used only if clearly needed and under medical supervision. It is also excreted in breast milk, so caution is advised when using this medication while breastfeeding.
• Diabetic Ketoacidosis: This insulin should not be used as the sole treatment for diabetic ketoacidosis, a serious complication of diabetes. Hospitalization and intravenous insulin therapy may be required in such cases.

Always consult with a healthcare provider before starting HUMULIN PROFILE-30 to ensure it is safe for your specific condition and health history.

Storage of HUMULIN PROFILE-30 100 IU/ml

Proper storage of HUMULIN PROFILE-30 is essential to maintain its effectiveness:

• Unopened Vials: Store the vials in the refrigerator at a temperature between 2°C and 8°C (36°F and 46°F). Do not freeze, and avoid storing the insulin vial directly next to the freezer compartment.
• Opened Vials: Once opened, HUMULIN PROFILE-30 can be kept at room temperature (below 30°C or 86°F) for up to 28 days. After this period, discard the vial, even if there is unused insulin left.
• Avoid Heat: Insulin should not be exposed to excessive heat or direct sunlight, as it can degrade the insulin's effectiveness.
• Protect from Freezing: If the insulin vial has been frozen, it should not be used. Dispose of any insulin that has been frozen.

Ensure that the insulin is stored away from children’s reach to prevent accidental misuse.