What is 50% w/v DEXTROSE INJECTION USP
50% w/v Dextrose Injection USP is a sterile, non-pyrogenic, hypertonic solution used primarily as a source of carbohydrate (caloric energy) and to treat severe hypoglycemia or insulin shock. This formulation contains 50 grams of dextrose (anhydrous) per 100 mL of solution, making it a highly concentrated glucose source administered intravenously.
- Form: Intravenous infusion (Solution for infusion)
- Packaging: 500ml plastic bag
- Active Ingredient: Dextrose (anhydrous), a simple sugar chemically identical to glucose
- Osmolarity: Hypertonic, which means it draws water out of cells and into the bloodstream
This solution is commonly used in emergency and critical care settings to:
- Correct dangerously low blood sugar levels
- Provide rapid energy during metabolic crises
- Serve as a caloric supplement in parenteral nutrition
How to use 50% w/v DEXTROSE INJECTION USP
The administration of 50% w/v Dextrose Injection USP should always be performed by a healthcare professional in a controlled setting, such as a hospital or emergency care unit. Due to its hypertonicity, improper use can lead to serious complications.
- Route: Intravenous (IV) only; should never be administered intramuscularly or subcutaneously
- Method: Can be infused slowly via peripheral or central vein; may require dilution depending on clinical indication
- Equipment: Use sterile IV sets and ensure compatibility with other medications or fluids
General precautions during administration include:
- Monitor blood glucose levels closely before, during, and after infusion
- Check for signs of extravasation (leakage into surrounding tissue) due to risk of tissue damage
- Assess hydration status and serum electrolytes regularly
Important: This product should be used cautiously in patients with impaired renal function, diabetes mellitus, or fluid overload conditions. Administration must be adjusted based on the patient’s metabolic requirements and fluid balance.
Mode of Action 50% w/v DEXTROSE INJECTION USP
The primary pharmacological action of 50% Dextrose Injection lies in its role as a readily available source of glucose. Dextrose, a monosaccharide, is vital for cellular metabolism, particularly in the brain and muscles.
- Rapid Absorption: Once administered intravenously, dextrose enters systemic circulation and is immediately available for cellular uptake.
- Energy Source: It provides an instant supply of energy by entering glycolysis and Krebs cycle pathways to generate ATP (adenosine triphosphate).
- Glycogen Restoration: In cases of hypoglycemia, dextrose helps replenish liver glycogen stores and correct energy deficits.
- Osmotic Effect: The hypertonic nature of 50% Dextrose increases intravascular osmolarity, drawing water into the blood vessels and raising plasma volume temporarily.
This action is particularly useful in emergency management of:
- Severe insulin-induced hypoglycemia
- Coma of unknown origin (suspected hypoglycemia)
- Alcohol-induced hypoglycemia
50% w/v DEXTROSE INJECTION USP Interactions 50% w/v DEXTROSE INJECTION USP
Dextrose Injection may interact with other medications or physiological states, affecting its efficacy or increasing the risk of complications. Below are key interactions to be aware of:
- Insulin: Co-administration increases glucose uptake, potentially leading to hypoglycemia if not properly monitored.
- Diuretics: Loop and thiazide diuretics may increase the risk of hyperglycemia or electrolyte imbalance when combined with dextrose infusions.
- Corticosteroids: These may reduce glucose tolerance and cause persistent hyperglycemia when used alongside dextrose.
- Cardiac Glycosides (e.g., Digoxin): Hypokalemia resulting from dextrose-induced insulin release can enhance the toxicity of digoxin.
- Parenteral Nutrition Components: Dextrose may interact with amino acids, lipids, or electrolytes in multi-nutrient infusions; compatibility must be checked.
Caution: Always inform the healthcare provider about any ongoing medications or supplements, especially in patients receiving chemotherapy, antidiabetics, or electrolyte-altering drugs.
Dosage of 50% w/v DEXTROSE INJECTION USP
The dosage of 50% Dextrose Injection USP must be individualized according to the patient's clinical condition, age, body weight, and severity of hypoglycemia. Always follow institutional protocols or the physician’s prescription.
- Adults (Severe Hypoglycemia): Typically, 25–50 mL (12.5–25 g) of 50% dextrose may be administered slowly via IV push over 3–5 minutes.
- Pediatrics: Not routinely used due to the risk of hyperosmolarity; diluted dextrose concentrations (e.g., 10%) are preferred.
- In Total Parenteral Nutrition (TPN): Infused slowly and titrated based on caloric requirements; usually diluted with other nutrients.
Monitoring Parameters:
- Blood glucose levels (before and after administration)
- Serum electrolytes (especially potassium and sodium)
- Hydration status and signs of fluid overload
Note: Rapid administration or overdose can result in hyperglycemia, osmotic diuresis, or phlebitis. Use with caution and under strict medical supervision.
Possible side effects of 50% w/v DEXTROSE INJECTION USP
While 50% Dextrose Injection is generally safe when used appropriately, it can cause adverse effects, particularly when administered rapidly or in excessive doses.
- Local Reactions:
- Thrombophlebitis
- Injection site pain or inflammation
- Extravasation injuries (necrosis, cellulitis)
- Systemic Effects:
- Hyperglycemia
- Hypokalemia due to insulin release
- Fluid overload or pulmonary edema (especially in renal/cardiac-compromised patients)
- Metabolic Abnormalities:
- Lactic acidosis (rare)
- Electrolyte disturbances such as hyponatremia
Patients should be monitored for these effects and managed accordingly. Discontinue use immediately if signs of hypersensitivity, confusion, or respiratory distress occur.
50% w/v DEXTROSE INJECTION USP Contraindications 50% w/v DEXTROSE INJECTION USP
This product is contraindicated in certain conditions where glucose metabolism is impaired or its administration may worsen the underlying issue.
- Uncontrolled Diabetes Mellitus: Risk of severe hyperglycemia and ketoacidosis
- Hyperosmolar states: Such as severe dehydration or hypernatremia
- Intracranial or Intraspinal Hemorrhage: Can increase intracranial pressure
- Delirium Tremens with Dehydration: Risk of electrolyte imbalance and worsening of symptoms
- Hypersensitivity to Dextrose: Rare but may manifest as rash, urticaria, or anaphylaxis
Precautions:
- Use cautiously in patients with renal impairment or heart failure
- Monitor for rebound hypoglycemia after infusion
- Avoid extravasation, which can lead to severe tissue damage
Storage of 50% w/v DEXTROSE INJECTION USP
Proper storage is essential to maintain the sterility and stability of the product.
- Temperature: Store below 25°C (77°F); do not freeze
- Light Protection: Keep away from direct sunlight and UV exposure
- Packaging Integrity: Use only if the plastic bag is intact and free from leaks or discoloration
- Expiration Date: Always check and adhere to the labeled expiry date
Additional Recommendations:
- Once opened or spiked, the solution should be used immediately or discarded
- Do not mix with incompatible drugs or solutions without verifying compatibility
- Discard any unused portion to prevent microbial contamination
Proper storage ensures both safety and efficacy of the medicine, especially in critical care scenarios.
50% w/v DEXTROSE INJECTION USP features an exceptional active ingredient renowned for its potent effects, comprising Dextrose (anhydrous). This powerful formulation provides a superior solution for addressing diverse health concerns. With 500mg/ml concentration and an easily manageable Infusion/Solution for, it remains a preferred option for countless individuals seeking effective treatment.
Introduction
All you need to know about 50% w/v DEXTROSE INJECTION USP .
Welcome to Dwaey, specifically on 50% w/v DEXTROSE INJECTION USP page.
This medicine contains an important and useful components, as it consists of Dextrose (anhydrous).
50% w/v DEXTROSE INJECTION USP is available in the market in concentration 500mg/ml and in the form of Infusion/Solution for.
QATAR PHARMA is the producer of 50% w/v DEXTROSE INJECTION USP and it is imported from QATAR,
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Frequently Asked Questions
50% w/v DEXTROSE INJECTION USP should be stored according to the instructions provided by QATAR PHARMA.
In general, it is recommended to store 50% w/v DEXTROSE INJECTION USP in a cool, dry place, away from direct sunlight
and out of the reach of children.
The duration of treatment with 50% w/v DEXTROSE INJECTION USP may vary depending on the condition being treated
and the guidance of your healthcare provider. It is important to follow the prescribed treatment
plan and continue taking 50% w/v DEXTROSE INJECTION USP for the recommended duration, even if your symptoms improve.
If you have any concerns or questions about the duration of treatment, consult your healthcare provider.
It is important to check with your healthcare provider or read the medication label for specific
instructions regarding alcohol consumption while taking 50% w/v DEXTROSE INJECTION USP. Some medications, including
50% w/v DEXTROSE INJECTION USP, may have interactions with alcohol that can reduce effectiveness, increase side
effects, or pose other risks to your health. It is best to follow the guidance provided by your
healthcare professional.
If you miss a dose of 50% w/v DEXTROSE INJECTION USP, take it as soon as you remember. However, if it is close
to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing
schedule. Do not take a double dose to make up for a missed one unless advised by your healthcare provider.
No, do not stop taking 50% w/v DEXTROSE INJECTION USP without consulting your healthcare provider, even if your
symptoms improve. It is important to complete the full course of treatment as prescribed. Stopping
the medication prematurely may lead to a relapse or incomplete resolution of the condition. If you
have concerns about the duration of treatment, consult your healthcare provider for guidance.
It is important to consult your healthcare provider before taking 50% w/v DEXTROSE INJECTION USP if you are
pregnant or breastfeeding. They will be able to assess the potential risks and benefits based on your
specific situation. Please note that the safety and suitability of 50% w/v DEXTROSE INJECTION USP during pregnancy
or breastfeeding may depend on the active substance [Active Substance], concentration 500mg/ml,
and the specific recommendations of QATAR PHARMA.
The effects of 50% w/v DEXTROSE INJECTION USP on your ability to drive or operate machinery can vary depending on
the active substance [Active Substance], concentration 500mg/ml, and individual factors.
Some medications may cause drowsiness, dizziness, or other side effects that can impair your judgment
or coordination. It is important to read the medication label or consult your healthcare provider to
understand any potential effects on your ability to perform tasks that require alertness.
The instructions for taking 50% w/v DEXTROSE INJECTION USP with or without food may vary depending on the medication
and the recommendations of QATAR PHARMA. Some medications may be more effective when taken with
food to enhance absorption or reduce stomach irritation, while others may need to be taken on an empty
stomach for optimal absorption. Read the medication label or consult your healthcare provider for specific instructions.
The use of 50% w/v DEXTROSE INJECTION USP in children or elderly individuals may depend on various factors, including
the specific medication, type Infusion/Solution for, and the recommendations of QATAR PHARMA. Some
medications may have specific dosing instructions or precautions for these age groups. Consult your
healthcare provider or read the medication label for information regarding the safe and appropriate use
of 50% w/v DEXTROSE INJECTION USP in children or elderly individuals.
Dwaey
All medical information published on the Dwaey website aims to increase medical awareness and health education among users. However, it is not a substitute for professional medical advice. Always consult with a specialist doctor. We strongly advise against using any information or medicine found on the site without referring to your healthcare provider.
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