What is 5% w/v DEXTROSE & 0.225% w/v SODIUM CHLORIDE INJECTION USP
5% w/v Dextrose & 0.225% w/v Sodium Chloride (MEDISAL) is a sterile, non-pyrogenic intravenous (IV) infusion solution used for rehydration and electrolyte replenishment. It combines dextrose (glucose) and sodium chloride to support metabolic and fluid balance in the body.
- Generic components: Dextrose (anhydrous) 5% and Sodium Chloride 0.225% per 100ml
- Form: Infusion solution for intravenous administration
- Packaging: 500ml plastic bottle (single-use, sterile)
- Use: Maintenance fluid therapy, mild electrolyte correction, and as a carrier fluid for IV medications
This hypotonic solution is commonly used in pediatric, neonatal, and adult patients for fluid therapy when a moderate volume of low-sodium IV fluid is required. The dextrose provides calories, while the sodium chloride helps maintain osmotic and electrolyte balance.
How to use 5% w/v DEXTROSE & 0.225% w/v SODIUM CHLORIDE INJECTION USP
This intravenous fluid must be administered carefully under the guidance of a healthcare professional. The 500ml plastic bottle allows for medium-volume fluid replacement or maintenance therapy.
- Pre-administration Checks:
- Inspect the solution for clarity and absence of particles.
- Ensure the bottle is intact and the expiration date is valid.
- Administration:
- Use a sterile IV set and connect to a peripheral or central venous line.
- Administer via IV drip or infusion pump depending on required control over the rate.
- Rate of infusion should be based on patient weight, clinical condition, and laboratory results.
- During Infusion:
- Monitor vital signs, serum glucose, and electrolytes periodically.
- Adjust infusion rate based on ongoing fluid loss or electrolyte levels.
Do not administer with blood products in the same line. Always use aseptic techniques and discard any unused portion after opening.
Mode of Action 5% w/v DEXTROSE & 0.225% w/v SODIUM CHLORIDE INJECTION USP
The therapeutic action of this solution is derived from its two active ingredients, working in synergy to rehydrate the body and support metabolism.
- Dextrose (5% w/v):
- Acts as a carbohydrate source, providing approximately 200 kcal per liter.
- Gets metabolized to CO₂ and water, releasing energy used by body cells.
- Prevents ketosis and muscle protein catabolism, especially in fasting or catabolic patients.
- Sodium Chloride (0.225% w/v):
- Supplies sodium and chloride ions, essential for neuromuscular function and fluid distribution.
- Supports osmotic equilibrium and maintains extracellular fluid volume.
This solution is hypotonic relative to plasma, leading to fluid shift into intracellular compartments, which can be beneficial in cases of cellular dehydration but must be used with caution to avoid hyponatremia.
5% w/v DEXTROSE & 0.225% w/v SODIUM CHLORIDE INJECTION USP Interactions 5% w/v DEXTROSE & 0.225% w/v SODIUM CHLORIDE INJECTION USP
Although this infusion fluid is considered safe, it may interact with certain drugs and conditions, especially those affecting glucose metabolism or fluid-electrolyte balance.
- Potential Drug Interactions:
- Insulin: Accelerates glucose uptake from dextrose, increasing the risk of hypoglycemia if glucose levels are not monitored.
- Corticosteroids: May lead to fluid retention and electrolyte imbalance.
- Diuretics: Particularly loop or thiazide diuretics can disturb sodium and potassium balance.
- Cardiac glycosides (e.g., digoxin): Hypokalemia induced by fluid therapy may enhance toxicity.
- Other Considerations:
- Avoid mixing with blood products due to risk of hemolysis.
- Ensure compatibility when using this solution as a diluent for intravenous medications.
- Concurrent use with nephrotoxic agents may increase renal stress.
Healthcare providers should evaluate the patient's medication profile and perform regular electrolyte monitoring to prevent adverse interactions during therapy.
Dosage of 5% w/v DEXTROSE & 0.225% w/v SODIUM CHLORIDE INJECTION USP
Dosage is individualized depending on the clinical condition, age, weight, and ongoing losses. The 500ml volume is commonly used for moderate hydration needs or maintenance therapy over a few hours.
- Adults:
- Typically used in volumes of 500–3000 ml/day depending on clinical need and fluid deficit.
- Infusion rate generally ranges from 50 to 150 ml/hour in adults.
- Pediatric:
- Maintenance fluids are calculated as 100 ml/kg for the first 10 kg, 50 ml/kg for the next 10 kg, and 20 ml/kg for any weight above 20 kg.
- Infusion rate is tailored per kg of body weight per hour.
- Neonates:
- Requires cautious administration. Daily fluid intake typically ranges from 60 to 100 ml/kg/day in the early days.
Adjustment may be needed for patients with renal or hepatic impairment, or in the presence of ongoing fluid loss (e.g., diarrhea, vomiting, burns). Regular lab monitoring is advised to guide ongoing therapy.
Possible side effects of 5% w/v DEXTROSE & 0.225% w/v SODIUM CHLORIDE INJECTION USP
While generally well tolerated, this IV solution can cause adverse reactions, particularly with improper administration, rapid infusion, or in vulnerable populations such as elderly or critically ill patients.
- Common Side Effects:
- Localized swelling or inflammation at the infusion site (phlebitis).
- Hyperglycemia, especially in patients with glucose intolerance or diabetes.
- Serious Side Effects:
- Fluid overload: Presents as pulmonary edema, hypertension, or heart failure symptoms.
- Electrolyte disturbances: Includes dilutional hyponatremia, hypokalemia, or hyperchloremia.
- Osmotic diuresis: Excess dextrose may lead to increased urination and fluid loss.
- Hypersensitivity Reactions:
- Rare, but may include rash, itching, or anaphylactic reactions.
Monitoring is essential during therapy to identify early signs of complications. Discontinue the infusion immediately if signs of intolerance or adverse reactions appear.
5% w/v DEXTROSE & 0.225% w/v SODIUM CHLORIDE INJECTION USP Contraindications 5% w/v DEXTROSE & 0.225% w/v SODIUM CHLORIDE INJECTION USP
This solution is not suitable for all patients. A thorough patient evaluation must be completed before administration to avoid complications.
- Absolute Contraindications:
- Known hypersensitivity to dextrose or sodium chloride.
- Severe hyperglycemia or glucose intolerance.
- Clinically significant hypernatremia or hyperchloremia.
- Relative Contraindications (Use with caution):
- Renal impairment – risk of fluid and sodium retention.
- Congestive heart failure – potential to worsen fluid overload.
- Head trauma or post-operative states – hypotonic solutions may worsen cerebral edema.
- Diabetes mellitus – may require insulin adjustment and close glucose monitoring.
Contraindications may vary based on the patient’s clinical scenario. Medical supervision is crucial when administering to at-risk groups.
Storage of 5% w/v DEXTROSE & 0.225% w/v SODIUM CHLORIDE INJECTION USP
Maintaining proper storage conditions ensures the safety and efficacy of the IV solution.
- Temperature:
- Store between 15°C and 25°C (room temperature).
- Avoid exposure to direct sunlight and freezing temperatures.
- Handling Instructions:
- Check the bottle integrity and clarity of the solution before use.
- Do not use if the solution is cloudy, discolored, or contains visible particles.
- Use aseptic technique when connecting to infusion sets.
- After Opening:
- Single-use only. Discard any unused portion after opening.
- Do not reconnect partially used bottles.
Always follow institutional protocols for storage, handling, and disposal of IV fluids to ensure patient safety and product stability.
5% w/v DEXTROSE & 0.225% w/v SODIUM CHLORIDE INJECTION USP features an exceptional active ingredient renowned for its potent effects, comprising Dextrose (anhydrous), Sodium chloride. This powerful formulation provides a superior solution for addressing diverse health concerns. With 50mg, 2.25mg/ml concentration and an easily manageable Infusion/Solution for, it remains a preferred option for countless individuals seeking effective treatment.
Introduction
All you need to know about 5% w/v DEXTROSE & 0.225% w/v SODIUM CHLORIDE INJECTION USP .
Welcome to Dwaey, specifically on 5% w/v DEXTROSE & 0.225% w/v SODIUM CHLORIDE INJECTION USP page.
This medicine contains an important and useful components, as it consists of Dextrose (anhydrous), Sodium chloride.
5% w/v DEXTROSE & 0.225% w/v SODIUM CHLORIDE INJECTION USP is available in the market in concentration 50mg, 2.25mg/ml and in the form of Infusion/Solution for.
QATAR PHARMA is the producer of 5% w/v DEXTROSE & 0.225% w/v SODIUM CHLORIDE INJECTION USP and it is imported from QATAR,
The most popular alternatives of 5% w/v DEXTROSE & 0.225% w/v SODIUM CHLORIDE INJECTION USP are listed downward .
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Dextrose (anhydrous), Sodium chloride
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Frequently Asked Questions
5% w/v DEXTROSE & 0.225% w/v SODIUM CHLORIDE INJECTION USP should be stored according to the instructions provided by QATAR PHARMA.
In general, it is recommended to store 5% w/v DEXTROSE & 0.225% w/v SODIUM CHLORIDE INJECTION USP in a cool, dry place, away from direct sunlight
and out of the reach of children.
The duration of treatment with 5% w/v DEXTROSE & 0.225% w/v SODIUM CHLORIDE INJECTION USP may vary depending on the condition being treated
and the guidance of your healthcare provider. It is important to follow the prescribed treatment
plan and continue taking 5% w/v DEXTROSE & 0.225% w/v SODIUM CHLORIDE INJECTION USP for the recommended duration, even if your symptoms improve.
If you have any concerns or questions about the duration of treatment, consult your healthcare provider.
It is important to check with your healthcare provider or read the medication label for specific
instructions regarding alcohol consumption while taking 5% w/v DEXTROSE & 0.225% w/v SODIUM CHLORIDE INJECTION USP. Some medications, including
5% w/v DEXTROSE & 0.225% w/v SODIUM CHLORIDE INJECTION USP, may have interactions with alcohol that can reduce effectiveness, increase side
effects, or pose other risks to your health. It is best to follow the guidance provided by your
healthcare professional.
If you miss a dose of 5% w/v DEXTROSE & 0.225% w/v SODIUM CHLORIDE INJECTION USP, take it as soon as you remember. However, if it is close
to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing
schedule. Do not take a double dose to make up for a missed one unless advised by your healthcare provider.
No, do not stop taking 5% w/v DEXTROSE & 0.225% w/v SODIUM CHLORIDE INJECTION USP without consulting your healthcare provider, even if your
symptoms improve. It is important to complete the full course of treatment as prescribed. Stopping
the medication prematurely may lead to a relapse or incomplete resolution of the condition. If you
have concerns about the duration of treatment, consult your healthcare provider for guidance.
It is important to consult your healthcare provider before taking 5% w/v DEXTROSE & 0.225% w/v SODIUM CHLORIDE INJECTION USP if you are
pregnant or breastfeeding. They will be able to assess the potential risks and benefits based on your
specific situation. Please note that the safety and suitability of 5% w/v DEXTROSE & 0.225% w/v SODIUM CHLORIDE INJECTION USP during pregnancy
or breastfeeding may depend on the active substance [Active Substance], concentration 50mg, 2.25mg/ml,
and the specific recommendations of QATAR PHARMA.
The effects of 5% w/v DEXTROSE & 0.225% w/v SODIUM CHLORIDE INJECTION USP on your ability to drive or operate machinery can vary depending on
the active substance [Active Substance], concentration 50mg, 2.25mg/ml, and individual factors.
Some medications may cause drowsiness, dizziness, or other side effects that can impair your judgment
or coordination. It is important to read the medication label or consult your healthcare provider to
understand any potential effects on your ability to perform tasks that require alertness.
The instructions for taking 5% w/v DEXTROSE & 0.225% w/v SODIUM CHLORIDE INJECTION USP with or without food may vary depending on the medication
and the recommendations of QATAR PHARMA. Some medications may be more effective when taken with
food to enhance absorption or reduce stomach irritation, while others may need to be taken on an empty
stomach for optimal absorption. Read the medication label or consult your healthcare provider for specific instructions.
The use of 5% w/v DEXTROSE & 0.225% w/v SODIUM CHLORIDE INJECTION USP in children or elderly individuals may depend on various factors, including
the specific medication, type Infusion/Solution for, and the recommendations of QATAR PHARMA. Some
medications may have specific dosing instructions or precautions for these age groups. Consult your
healthcare provider or read the medication label for information regarding the safe and appropriate use
of 5% w/v DEXTROSE & 0.225% w/v SODIUM CHLORIDE INJECTION USP in children or elderly individuals.
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All medical information published on the Dwaey website aims to increase medical awareness and health education among users. However, it is not a substitute for professional medical advice. Always consult with a specialist doctor. We strongly advise against using any information or medicine found on the site without referring to your healthcare provider.
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