FIBURIK 80mg F/C tablet

What is FIBURIK 80mg

FIBURIK 80 mg is a prescription medication containing 80 milligrams of febuxostat, an active ingredient used to manage hyperuricemia associated with gout. It belongs to the class of drugs called xanthine oxidase inhibitors and is designed to lower elevated levels of uric acid in the blood.

This medicine is indicated for adult patients who suffer from gout, a condition characterized by painful inflammation in the joints caused by uric acid crystal deposits. FIBURIK 80 mg helps prevent gout attacks by reducing uric acid levels, which minimizes the formation of these painful crystals.

The medication comes as film-coated tablets, typically supplied in blister packs containing 30 tablets (3 strips of 10 tablets each). It offers an effective alternative for patients who have not achieved desired uric acid control with other medications or who are intolerant to them.

How to use FIBURIK 80mg

FIBURIK 80 mg tablets are taken orally once daily, with or without food. It is recommended to swallow the tablets whole with a glass of water. The medication should be taken at the same time every day to maintain consistent blood levels and ensure effectiveness.

Patients often experience an initial increase in gout flare-ups during the first few weeks of treatment as uric acid levels adjust. To minimize this, doctors typically advise co-administration with anti-inflammatory drugs like colchicine or NSAIDs during the first 3 to 6 months.

It is important not to stop taking FIBURIK suddenly without consulting your healthcare provider, even if symptoms improve, as this may cause uric acid levels to rise again. Regular monitoring of uric acid levels and kidney function tests is advisable during therapy.

Mode of Action FIBURIK 80mg

Febuxostat, the active ingredient in FIBURIK 80 mg, is a selective inhibitor of the enzyme xanthine oxidase. This enzyme plays a crucial role in the metabolic pathway that converts purines into uric acid.

By selectively inhibiting xanthine oxidase, febuxostat reduces the production of uric acid, lowering its concentration in the blood. This decrease helps prevent the formation and accumulation of uric acid crystals in joints and tissues, which cause the symptoms of gout.

Febuxostat’s selectivity means it targets xanthine oxidase specifically without significantly affecting other enzymes, making it well tolerated with a favorable safety profile. This targeted action also makes it suitable for use in patients with mild to moderate kidney impairment.

FIBURIK 80mg Interactions FIBURIK 80mg

FIBURIK 80 mg (febuxostat) may interact with several medications. It is essential to disclose all current medications to your healthcare provider to avoid potential drug interactions.

• Mercaptopurine and Azathioprine: Febuxostat inhibits enzymes that metabolize these drugs, increasing their toxicity. Concurrent use is contraindicated.
• Theophylline: Febuxostat may increase theophylline levels; monitoring for toxicity is recommended.
• Warfarin: Although interactions are uncommon, patients should have their blood coagulation parameters (INR) closely monitored when starting or stopping febuxostat.
• NSAIDs and Colchicine: Commonly used alongside febuxostat to prevent gout flares during treatment initiation, but dosing and monitoring are necessary.

Patients should avoid starting or stopping medications without consulting their healthcare provider.

Dosage of FIBURIK 80mg

The recommended starting dose of FIBURIK is usually 40 mg once daily. If serum uric acid levels remain above 6 mg/dL after two weeks, the dose can be increased to 80 mg once daily for better control.

FIBURIK 80 mg is usually prescribed for patients requiring higher potency to reach target uric acid levels. Dosage adjustments are generally unnecessary in mild to moderate renal impairment but should be done cautiously in severe hepatic or renal dysfunction.

The medication should be taken consistently, and patients are advised to maintain hydration and lifestyle modifications to support treatment.

Possible side effects of FIBURIK 80mg

Common side effects may include:

• Headache
• Nausea or stomach upset
• Rash or skin reactions
• Elevated liver enzymes (usually reversible)

Less common but serious side effects include:

• Severe allergic reactions such as Stevens-Johnson syndrome
• Liver injury requiring discontinuation
• Cardiovascular events including heart attack or stroke, especially in patients with pre-existing heart disease

Patients should promptly report severe symptoms like rash, jaundice, chest pain, or shortness of breath. Regular blood tests are recommended to monitor safety during treatment.

FIBURIK 80mg Contraindications FIBURIK 80mg

FIBURIK 80 mg should not be used in patients with:

• Known hypersensitivity to febuxostat or formulation components
• Concurrent use of mercaptopurine or azathioprine
• Severe liver impairment
• Pregnant or breastfeeding women unless clearly advised by a healthcare professional
• History of serious cardiovascular disease should be considered cautiously

Patients with severe renal or hepatic disease require careful monitoring and individualized risk-benefit assessment.

Storage of FIBURIK 80mg

Proper storage is essential to maintain the drug’s efficacy:

• Store at room temperature between 15°C and 30°C (59°F to 86°F)
• Keep in original blister packs to protect from moisture and light
• Store away from children and pets
• Do not use beyond the expiration date on the package

Expired or unused tablets should be disposed of according to local regulations or pharmacy guidelines to prevent environmental contamination or accidental ingestion.