FIBRO-VEIN 3% Injection/Solution for

What is FIBRO-VEIN 3%

Description

FIBRO-VEIN 3% is a sterile, injectable solution that contains 30 mg/mL of sodium tetradecyl sulfate. It is used in the treatment of varicose veins through a medical procedure called sclerotherapy.

Pharmaceutical Form

It comes in 2 mL ampoules, with each pack containing 5 ampoules. The solution is clear and colorless and is administered directly into the affected veins.

Classification

It belongs to a class of medicines known as sclerosing agents, which work by irritating the vein wall, causing it to collapse and be absorbed by the body over time.

Indications

• Treatment of small to medium-sized varicose veins
• Management of reticular veins and spider veins
• Adjunct therapy in chronic venous insufficiency

How to use FIBRO-VEIN 3%

Administration Method

FIBRO-VEIN 3% is administered by a healthcare professional using a fine needle. The medication is injected directly into the affected vein under sterile conditions.

Steps for Use

• Preparation: Clean and disinfect the injection area.
• Injection: Slowly inject into the vein, avoiding extravasation.
• Compression: Apply compression post-injection to help close the vein.
• Post-treatment Monitoring: Monitor the patient for allergic reactions or complications.

Patient Instructions

Patients should wear compression stockings after the procedure and avoid strenuous activities for 48 hours. Standing for long periods and sun exposure to the treated area should also be minimized.

Mode of Action FIBRO-VEIN 3%

Pharmacological Action

Sodium tetradecyl sulfate acts as a detergent, damaging the endothelium (inner lining) of the vein. This causes a localized inflammatory response that leads to clot formation and fibrosis.

Physiological Response

The vein becomes occluded, and over time the body reabsorbs the fibrosed vein, rerouting blood through healthier veins. This improves circulation and reduces visible varicosities.

Outcome

Proper use results in the elimination of dysfunctional veins, improving both cosmetic appearance and venous function.

FIBRO-VEIN 3% Interactions FIBRO-VEIN 3%

Interactions with Other Medications

Overview

FIBRO-VEIN 3% has minimal systemic absorption, but some precautions should be taken if used with certain medications.

Potential Drug Interactions

• Anticoagulants (e.g., warfarin, heparin): May increase bleeding risk post-injection.
• Hormonal contraceptives: May compound the risk of venous thromboembolism (VTE).
• Other sclerosing agents: Using multiple agents together may increase irritation or toxicity.

Clinical Advice

Always inform your healthcare provider of all current medications, including supplements and herbal remedies, to prevent adverse interactions or complications.

Dosage of FIBRO-VEIN 3%

Typical Dosage

The exact dose depends on vein size and number of areas being treated. The dose is determined by a physician based on clinical evaluation.

Dosage Guidelines

• Inject 0.1 to 1.0 mL per vein segment.
• Maximum recommended total dose per session: 10 mL.
• Do not exceed treatment of more than 10 sites per session unless under strict medical supervision.

Frequency

Sessions are typically spaced 4–6 weeks apart. Multiple treatments may be needed for complete resolution.

Possible side effects of FIBRO-VEIN 3%

Common Side Effects

• Injection site redness, swelling, or bruising
• Temporary skin discoloration (hyperpigmentation)
• Mild pain or tingling sensation post-procedure

Less Common but Serious Side Effects

• Superficial thrombophlebitis (inflammation of the treated vein)
• Tissue necrosis if injected outside the vein (extravasation)
• Allergic reactions including rash or anaphylaxis
• Deep vein thrombosis (DVT) or pulmonary embolism (rare)

Monitoring and Reporting

Patients should be monitored after administration and instructed to report any severe pain, respiratory issues, or signs of infection immediately.

FIBRO-VEIN 3% Contraindications FIBRO-VEIN 3%

Absolute Contraindications

• Known allergy or hypersensitivity to sodium tetradecyl sulfate
• Active local or systemic infections
• Severe arterial insufficiency
• Acute thromboembolic disorders

Relative Contraindications

• Pregnancy and breastfeeding
• Bedridden patients or those with limited mobility
• Uncontrolled diabetes or hypertension
• Recent surgery or trauma at the site of injection

Storage of FIBRO-VEIN 3%

Storage Conditions

• Store between 2°C and 25°C (36°F to 77°F).
• Do not freeze.
• Keep the ampoules in original packaging to protect from light.
• Use before the expiration date printed on the label.

Handling and Disposal

Open ampoules must be used immediately. Discard any unused solution and used containers as per local medical waste disposal guidelines.