FIBRO-VEIN 1% Injection/Solution for

What is FIBRO-VEIN 1%

FIBRO-VEIN 1% is a sterile injectable solution that contains the active ingredient sodium tetradecyl sulfate, a synthetic surfactant used as a sclerosing agent. It is formulated for intravenous use to treat varicose veins and other chronic venous insufficiencies. Each 2 ml ampoule contains a 1% concentration, equivalent to 20 mg of sodium tetradecyl sulfate.

Therapeutic Class

It belongs to the class of medications called sclerosing agents, designed to damage the inner lining of veins, causing them to collapse and eventually be reabsorbed by the body.

Indications

• Treatment of small to medium-sized varicose veins
• Management of spider veins (telangiectasias)
• Adjunct therapy in chronic venous insufficiency

How to use FIBRO-VEIN 1%

FIBRO-VEIN 1% must be administered by a qualified healthcare provider in a clinical setting. This is to ensure correct placement and technique, as improper use can lead to serious complications.

Administration Steps

• 1. Preparation: Ensure the injection site is sterile and the patient is positioned appropriately.
• 2. Injection: Inject the medication slowly into the targeted vein using a fine needle.
• 3. Post-injection care: Apply compression to the treated area to enhance efficacy and reduce adverse reactions.
• 4. Monitoring: Observe the patient for 15–30 minutes post-procedure to manage any acute reactions.

Patient Instructions

• Wear compression stockings as advised by the physician.
• Avoid prolonged standing, hot baths, and strenuous activities for at least 48 hours post-treatment.

Mode of Action FIBRO-VEIN 1%

Sodium tetradecyl sulfate acts as a detergent that irritates the endothelium of veins upon contact. This irritation causes inflammation, leading to thrombosis of the vein and subsequent fibrosis. Over time, the occluded vein is reabsorbed and no longer visible under the skin.

Pharmacodynamics

• Destroys endothelial cells lining the vein wall
• Triggers localized clotting within the vessel
• Leads to fibrotic closure of the vein over time

Therapeutic Goal

The ultimate aim is to eliminate unsightly or symptomatic varicosities while preserving overall venous return via unaffected vessels.

FIBRO-VEIN 1% Interactions FIBRO-VEIN 1%

FIBRO-VEIN 1% generally has a low risk of drug interactions due to its local action. However, caution is warranted in patients taking systemic medications that affect vascular function or coagulation.

Notable Drug Interactions

• Anticoagulants (e.g., warfarin): May increase risk of excessive bleeding at injection sites.
• Oral contraceptives: Can raise the baseline risk for thromboembolic events.
• Other sclerosants: Avoid concurrent use to prevent overdose or cumulative vein damage.

Clinical Advice

Inform your healthcare provider about all ongoing medications, herbal supplements, and any known allergies before receiving treatment with FIBRO-VEIN 1%.

Dosage of FIBRO-VEIN 1%

Dosage depends on the size, number, and location of varicosities. It is tailored per session by the treating physician. One session can include multiple injections, and multiple sessions may be needed for complete therapy.

Typical Dosage Range

• 0.1 to 1.0 mL per injection site
• Not more than 10 mL per treatment session
• Intervals between sessions: 4–6 weeks

Clinical Notes

• Inject slowly and avoid intra-arterial administration.
• Avoid treatment of more than 10 sites in one session unless otherwise advised.

Possible side effects of FIBRO-VEIN 1%

As with any injectable medication, FIBRO-VEIN 1% can cause side effects ranging from mild and localized to systemic and rare.

Common Adverse Effects

• Pain, redness, or swelling at the injection site
• Skin hyperpigmentation
• Temporary bruising or discomfort

Rare But Serious Effects

• Allergic reaction (rash, hives, anaphylaxis)
• Tissue necrosis if injected outside the vein
• Superficial or deep thrombophlebitis
• Pulmonary embolism or deep vein thrombosis (DVT)

Monitoring

Patients should be monitored during and after treatment, especially if there is a history of clotting disorders or allergic reactions.

FIBRO-VEIN 1% Contraindications FIBRO-VEIN 1%

FIBRO-VEIN 1% should not be administered to patients with conditions that may be exacerbated by vein occlusion or who are at heightened risk of adverse vascular events.

Absolute Contraindications

• Known hypersensitivity to sodium tetradecyl sulfate
• Active thromboembolic disorders (e.g., DVT)
• Severe arterial insufficiency or ischemia
• Local or systemic infection

Relative Contraindications

• Pregnancy and breastfeeding (insufficient safety data)
• Immobility or bed confinement
• History of severe allergic reactions

Storage of FIBRO-VEIN 1%

Proper storage conditions are essential to preserve the stability and sterility of FIBRO-VEIN 1%.

Storage Instructions

• Store between 2°C and 25°C (36°F to 77°F)
• Protect from direct light and moisture
• Do not freeze
• Keep in original packaging until use
• Discard any unused solution according to medical waste guidelines