FIBRO-VEIN 0.5% Injection/Solution for

What is FIBRO-VEIN 0.5%

FIBRO-VEIN 0.5% is a sterile injectable solution that contains sodium tetradecyl sulfate, which acts as a sclerosing agent. It is primarily used for the treatment of small to medium-sized varicose veins and spider veins.

The solution is presented in 2 ml ampoules, with each milliliter containing 5 mg of sodium tetradecyl sulfate, making it a 0.5% concentration.

Key Features:

• Generic Name: Sodium tetradecyl sulfate
• Form: Injectable solution
• Strength: 0.5% (5 mg/mL)
• Packaging: 2ml ampoule x 5
• Use: Sclerotherapy for varicose/spider veins

Indications:

• Treatment of telangiectasias (spider veins)
• Treatment of reticular veins
• Adjunct in the treatment of larger varicose veins

How to use FIBRO-VEIN 0.5%

FIBRO-VEIN 0.5% is administered by a healthcare professional through an injection into the affected vein using a fine needle. The treatment must be conducted under sterile conditions to avoid complications.

Steps for Use:

• 1. Preparation: Clean the skin and identify the target vein.
• 2. Injection: Inject a small volume of the solution directly into the vein.
• 3. Compression: Apply compression to promote vein closure and prevent clotting.
• 4. Post-Care: The patient may need to wear compression stockings and avoid vigorous activity for 24-48 hours.

Mode of Action FIBRO-VEIN 0.5%

Sodium tetradecyl sulfate works as a surfactant that damages the endothelial lining of veins upon contact.

This leads to inflammation, clot formation, and eventual fibrosis of the vessel, resulting in permanent vein occlusion and disappearance of the varicosity.

Pharmacodynamics:

• Endothelial disruption triggers platelet aggregation and thrombus formation.
• Fibrotic tissue replaces the damaged vein over time.
• Blood is rerouted to healthy veins, improving circulation and reducing varicosities.

FIBRO-VEIN 0.5% Interactions FIBRO-VEIN 0.5%

Though not commonly associated with significant drug interactions, caution is advised when used with medications that affect blood clotting or vascular tone.

Potential Drug Interactions:

• Anticoagulants/Antiplatelets: May increase the risk of bleeding or bruising.
• Hormonal contraceptives: Combined use may heighten thrombotic risk.
• Other sclerosants: Avoid simultaneous use to prevent overdose or compounded effects.

Dosage of FIBRO-VEIN 0.5%

The dosage depends on the extent of the venous condition and patient-specific factors. It must always be individualized and administered by a trained clinician.

Typical Dosage Guidelines:

• 0.1 to 1.0 mL per injection site.
• Maximum 10 mL of solution per treatment session.
• Sessions can be repeated every 4–6 weeks as needed.

Administration Advice:

• Use a fine-gauge needle to minimize trauma.
• Do not inject into arteries or extravascular tissues.
• Observe the patient post-injection for adverse reactions.

Possible side effects of FIBRO-VEIN 0.5%

Like all medications, FIBRO-VEIN 0.5% can cause side effects, ranging from mild to serious. Most are local and transient.

Common Side Effects:

• Redness or irritation at the injection site
• Bruising, tenderness, or swelling
• Hyperpigmentation along the treated vein

Serious or Rare Effects:

• Allergic reactions including rash or anaphylaxis
• Superficial thrombophlebitis
• Tissue necrosis if extravasation occurs
• Deep vein thrombosis (DVT) or pulmonary embolism

FIBRO-VEIN 0.5% Contraindications FIBRO-VEIN 0.5%

FIBRO-VEIN 0.5% should not be used in certain populations or clinical situations due to potential risks.

Absolute Contraindications:

• Known hypersensitivity to sodium tetradecyl sulfate
• Acute superficial or deep vein thrombosis
• Severe arterial disease
• Severe systemic infections or uncontrolled diabetes
• Immobility or bedridden patients

Relative Contraindications:

• Pregnancy and lactation
• History of thromboembolic events
• Recent surgery or trauma to the area

Storage of FIBRO-VEIN 0.5%

Storage of FIBRO-VEIN 0.5%

Proper storage ensures the efficacy and safety of FIBRO-VEIN 0.5% over its shelf life.

Storage Instructions:

• Store at 2°C to 25°C (36°F to 77°F).
• Protect from direct light and moisture.
• Do not freeze the solution.
• Keep ampoules in original packaging until use.
• Dispose of unused product according to local regulations.