What is 25% w/v DEXTROSE INJECTION USP
25% w/v Dextrose Injection USP is a sterile, hypertonic intravenous solution containing 25 grams of anhydrous dextrose per 100 milliliters of water. It is commonly supplied in a 500ml plastic bottle for medical use.
- Purpose: This medication is primarily used to provide a source of calories and fluids for patients who cannot consume food orally or require intravenous supplementation due to illness or surgery.
- Composition: The active ingredient, dextrose (an anhydrous form of glucose), acts as a carbohydrate source, supplying energy to the body's cells.
- Indications: It is indicated for patients with hypoglycemia, dehydration, or as part of parenteral nutrition. It may also be used in cases of insulin shock, to correct electrolyte imbalances, or to dilute other medications for intravenous administration.
- Form: The solution is clear, colorless, and free from visible particles, making it safe for intravenous infusion.
- Clinical Setting: Used extensively in hospitals, clinics, and emergency care to restore blood sugar levels and provide essential hydration and nutrition when oral intake is not possible or inadequate.
How to use 25% w/v DEXTROSE INJECTION USP
Administering 25% Dextrose Injection requires careful clinical assessment and strict adherence to protocols to ensure safety and efficacy.
- Administration Route: This medication is administered intravenously (IV) only. It should never be given by intramuscular or subcutaneous routes due to tissue irritation and potential complications.
- Preparation: Prior to administration, the solution should be inspected for clarity and absence of particles. If mixed with other drugs, compatibility must be verified to avoid precipitation or loss of efficacy.
- Dilution: In some cases, dilution with sterile water or normal saline might be necessary depending on the patient’s fluid and sugar requirements.
- Infusion Rate: The infusion rate must be carefully controlled and adjusted according to patient age, weight, and clinical condition to prevent complications such as hyperglycemia or fluid overload.
- Monitoring: Blood glucose levels, electrolytes, and fluid balance should be regularly monitored during infusion to adjust dosage and avoid adverse effects.
- Use in Emergency: In hypoglycemic emergencies, it can be administered as a bolus injection under close supervision.
Mode of Action 25% w/v DEXTROSE INJECTION USP
The primary mechanism by which 25% w/v Dextrose Injection exerts its therapeutic effect is by supplying glucose directly into the bloodstream.
- Energy Supply: Dextrose is a simple sugar that is rapidly absorbed and metabolized by the body's cells to produce energy (ATP), vital for cellular function, especially in the brain and muscles.
- Metabolic Pathways: Once administered intravenously, dextrose enters glycolysis and the Krebs cycle, leading to ATP generation.
- Blood Glucose Regulation: It increases blood glucose levels promptly, which is crucial in treating hypoglycemia or maintaining energy balance in fasting or critically ill patients.
- Osmotic Effect: Due to its hypertonic nature, it draws water from intracellular to extracellular compartments, helping to correct dehydration and maintain plasma volume.
- Supporting Nutrition: When used as part of parenteral nutrition, it serves as a key carbohydrate source alongside amino acids and lipids.
25% w/v DEXTROSE INJECTION USP Interactions 25% w/v DEXTROSE INJECTION USP
Dextrose infusion can interact with various medications, potentially affecting efficacy and safety.
- Insulin and Hypoglycemics: Dextrose may reduce the effectiveness of insulin and other antidiabetic drugs by increasing blood sugar levels, requiring dose adjustments.
- Diuretics: Concomitant use with diuretics like furosemide can affect electrolyte balance, particularly potassium levels, necessitating close monitoring.
- Warfarin: High glucose levels can alter warfarin metabolism, affecting anticoagulant control.
- Drugs Requiring Dilution: Compatibility must be checked before co-administration with other IV drugs, as dextrose solutions can cause precipitation or inactivation of some medications (e.g., aminoglycosides, amphotericin B in certain solutions).
- Corticosteroids and Catecholamines: These can increase blood glucose levels, potentially intensifying hyperglycemia risks when combined with dextrose infusion.
Dosage of 25% w/v DEXTROSE INJECTION USP
Dosage of 25% Dextrose Injection depends on the patient’s clinical condition, age, weight, and metabolic needs.
- Adults: Typical maintenance or replacement doses range from 100 to 300 ml infused over several hours, adjusted based on blood glucose and fluid status.
- Emergency Use: In hypoglycemic shock, 25-50 ml may be given as a rapid intravenous bolus to quickly restore blood glucose levels.
- Pediatric Use: Dosage is carefully calculated on a weight basis, often between 0.5 to 1 gram/kg of dextrose, administered slowly with continuous monitoring.
- Continuous Infusion: May be used in combination with electrolytes and other nutrients in parenteral nutrition solutions for critically ill patients.
- Adjustment: Dosage should be modified based on blood glucose levels, kidney function, and patient response to avoid hyperglycemia or fluid overload.
Possible side effects of 25% w/v DEXTROSE INJECTION USP
While generally safe when administered appropriately, 25% Dextrose Injection can cause side effects, especially if given improperly or in excess.
- Local Reactions: Pain, irritation, or phlebitis at the injection site due to hypertonic solution.
- Hyperglycemia: Elevated blood sugar levels may cause symptoms such as increased thirst, frequent urination, headache, and in severe cases, diabetic ketoacidosis.
- Electrolyte Imbalance: Can cause shifts in sodium, potassium, and fluid balance leading to complications like edema, hypokalemia, or hypernatremia.
- Fluid Overload: Excessive administration may lead to pulmonary edema, hypertension, and congestive heart failure, especially in patients with cardiac or renal impairment.
- Allergic Reactions: Rare, but may include rash, itching, or anaphylaxis.
- Other: Headache, dizziness, or nausea may occur in some cases.
25% w/v DEXTROSE INJECTION USP Contraindications 25% w/v DEXTROSE INJECTION USP
Certain medical conditions and patient factors contraindicate the use of 25% Dextrose Injection.
- Hyperglycemia: Patients with uncontrolled diabetes or hyperosmolar states should avoid dextrose solutions to prevent exacerbation of hyperglycemia.
- Severe Dehydration Without Electrolyte Replacement: Using hypertonic dextrose alone can worsen electrolyte imbalance.
- Known Allergy: Hypersensitivity to dextrose or any component of the formulation.
- Intracranial or Intraspinal Hemorrhage: Hyperosmolar solutions may worsen cerebral edema or increase intracranial pressure.
- Severe Renal or Cardiac Failure: Due to risk of fluid overload and electrolyte disturbances.
Storage of 25% w/v DEXTROSE INJECTION USP
Proper storage of 25% w/v Dextrose Injection ensures its potency and safety.
- Temperature: Store at controlled room temperature, ideally between 20°C and 25°C (68°F and 77°F). Avoid freezing as it can damage the solution and container.
- Light Protection: Keep the solution in its original packaging to protect from light exposure that could degrade the product.
- Handling: Avoid shaking vigorously to prevent foaming or contamination.
- Expiry: Use before the expiration date indicated on the bottle. Do not use if the solution appears discolored, cloudy, or contains particles.
- Storage Environment: Store in a clean, dry place away from direct heat sources and incompatible substances.
25% w/v DEXTROSE INJECTION USP features an exceptional active ingredient renowned for its potent effects, comprising Dextrose (anhydrous). This powerful formulation provides a superior solution for addressing diverse health concerns. With 250mg/ml concentration and an easily manageable Infusion/Solution for, it remains a preferred option for countless individuals seeking effective treatment.
Introduction
All you need to know about 25% w/v DEXTROSE INJECTION USP .
Welcome to Dwaey, specifically on 25% w/v DEXTROSE INJECTION USP page.
This medicine contains an important and useful components, as it consists of Dextrose (anhydrous).
25% w/v DEXTROSE INJECTION USP is available in the market in concentration 250mg/ml and in the form of Infusion/Solution for.
QATAR PHARMA is the producer of 25% w/v DEXTROSE INJECTION USP and it is imported from QATAR,
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Frequently Asked Questions
25% w/v DEXTROSE INJECTION USP should be stored according to the instructions provided by QATAR PHARMA.
In general, it is recommended to store 25% w/v DEXTROSE INJECTION USP in a cool, dry place, away from direct sunlight
and out of the reach of children.
The duration of treatment with 25% w/v DEXTROSE INJECTION USP may vary depending on the condition being treated
and the guidance of your healthcare provider. It is important to follow the prescribed treatment
plan and continue taking 25% w/v DEXTROSE INJECTION USP for the recommended duration, even if your symptoms improve.
If you have any concerns or questions about the duration of treatment, consult your healthcare provider.
It is important to check with your healthcare provider or read the medication label for specific
instructions regarding alcohol consumption while taking 25% w/v DEXTROSE INJECTION USP. Some medications, including
25% w/v DEXTROSE INJECTION USP, may have interactions with alcohol that can reduce effectiveness, increase side
effects, or pose other risks to your health. It is best to follow the guidance provided by your
healthcare professional.
If you miss a dose of 25% w/v DEXTROSE INJECTION USP, take it as soon as you remember. However, if it is close
to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing
schedule. Do not take a double dose to make up for a missed one unless advised by your healthcare provider.
No, do not stop taking 25% w/v DEXTROSE INJECTION USP without consulting your healthcare provider, even if your
symptoms improve. It is important to complete the full course of treatment as prescribed. Stopping
the medication prematurely may lead to a relapse or incomplete resolution of the condition. If you
have concerns about the duration of treatment, consult your healthcare provider for guidance.
It is important to consult your healthcare provider before taking 25% w/v DEXTROSE INJECTION USP if you are
pregnant or breastfeeding. They will be able to assess the potential risks and benefits based on your
specific situation. Please note that the safety and suitability of 25% w/v DEXTROSE INJECTION USP during pregnancy
or breastfeeding may depend on the active substance [Active Substance], concentration 250mg/ml,
and the specific recommendations of QATAR PHARMA.
The effects of 25% w/v DEXTROSE INJECTION USP on your ability to drive or operate machinery can vary depending on
the active substance [Active Substance], concentration 250mg/ml, and individual factors.
Some medications may cause drowsiness, dizziness, or other side effects that can impair your judgment
or coordination. It is important to read the medication label or consult your healthcare provider to
understand any potential effects on your ability to perform tasks that require alertness.
The instructions for taking 25% w/v DEXTROSE INJECTION USP with or without food may vary depending on the medication
and the recommendations of QATAR PHARMA. Some medications may be more effective when taken with
food to enhance absorption or reduce stomach irritation, while others may need to be taken on an empty
stomach for optimal absorption. Read the medication label or consult your healthcare provider for specific instructions.
The use of 25% w/v DEXTROSE INJECTION USP in children or elderly individuals may depend on various factors, including
the specific medication, type Infusion/Solution for, and the recommendations of QATAR PHARMA. Some
medications may have specific dosing instructions or precautions for these age groups. Consult your
healthcare provider or read the medication label for information regarding the safe and appropriate use
of 25% w/v DEXTROSE INJECTION USP in children or elderly individuals.
Dwaey
All medical information published on the Dwaey website aims to increase medical awareness and health education among users. However, it is not a substitute for professional medical advice. Always consult with a specialist doctor. We strongly advise against using any information or medicine found on the site without referring to your healthcare provider.
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