What is 2.5% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP
2.5% W/V Dextrose & 0.45% W/V Sodium Chloride (MEDISAL) is a sterile intravenous infusion solution commonly used in clinical settings to provide both fluid and nutritional support. It combines two essential components: dextrose and sodium chloride, formulated in a balanced manner to address dehydration, electrolyte imbalances, and mild energy deficits.
- Dextrose (2.5%) is a form of glucose, a simple sugar that serves as a critical energy source for cellular metabolism. It supports patients who cannot consume adequate calories orally or who require supplemental glucose during illness or fasting.
- Sodium Chloride (0.45%) is a hypotonic saline solution that helps restore sodium and chloride ions lost due to dehydration, sweating, or other medical conditions. It maintains osmotic balance and supports proper nerve and muscle function.
- This particular formulation is slightly hypotonic, meaning it can provide free water to cells while maintaining vascular volume, making it ideal for maintenance hydration or correcting mild electrolyte disturbances.
- It comes in a 500ml plastic bottle suitable for controlled intravenous infusion under medical supervision.
How to use 2.5% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP
This solution is designed strictly for intravenous infusion and must be administered by healthcare professionals in controlled clinical environments. Proper administration is crucial to avoid complications.
- Administration Route: Intravenous infusion through a suitable venous access device (e.g., cannula or central line).
- Preparation: Before use, inspect the solution for clarity, colorlessness, and absence of particulate matter. Do not use if the container is damaged or the solution appears cloudy.
- Infusion Rate: Tailored to the patient's fluid and metabolic needs, typically started at a slow rate and adjusted according to clinical response and laboratory results.
- Monitoring: Continuous monitoring of vital signs, blood glucose, and serum electrolytes is recommended, especially for patients with diabetes, renal impairment, or cardiac disease.
- Compatibility: Avoid mixing with incompatible drugs in the same infusion line unless compatibility is verified.
- Single-use container: Discard any unused portion after opening to prevent contamination.
Mode of Action 2.5% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP
The therapeutic effects arise from the combined physiological actions of dextrose and sodium chloride in this infusion.
- Dextrose:
- Rapidly metabolized by cells to produce energy via glycolysis, supporting vital functions during fasting or illness.
- Helps maintain blood glucose levels, preventing hypoglycemia in patients unable to eat or with increased metabolic demands.
- Acts as a protein-sparing agent, reducing catabolism of body proteins by providing an alternative energy source.
- Sodium Chloride:
- Supplies sodium ions essential for maintaining extracellular fluid volume and osmotic pressure.
- Supports neuromuscular function by preserving ionic gradients across membranes.
- Provides chloride ions, which play a role in acid-base balance and gastric secretions.
- The hypotonic nature facilitates free water movement into cells, aiding in cellular hydration.
2.5% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP Interactions 2.5% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP
While generally safe, this infusion can interact with certain medications and clinical conditions, which must be taken into account during treatment planning.
- Insulin and Hypoglycemic Agents: Insulin enhances cellular glucose uptake; concomitant use may increase the risk of hypoglycemia if dextrose supply is insufficient or if insulin dosage is not adjusted.
- Diuretics (Loop and Thiazide): May cause enhanced loss of sodium and potassium, potentially leading to electrolyte imbalances when combined with this infusion.
- Corticosteroids and Mineralocorticoids: These can promote sodium retention and potassium loss, exacerbating fluid overload or electrolyte disturbances.
- Cardiac Glycosides (e.g., Digoxin): Electrolyte imbalances, particularly hypokalemia, induced by this infusion or other drugs can increase the risk of digoxin toxicity.
- Renal Impairment: Reduced clearance of sodium and fluids can lead to fluid overload and electrolyte imbalance, necessitating close monitoring.
Dosage of 2.5% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP
Dosage depends on the individual patient's clinical condition, fluid requirements, and metabolic status. Only a qualified healthcare provider should determine dosing.
- Adults: Typically administered at 500 to 1000 mL per day, adjusted based on hydration status and electrolyte needs.
- Children: Dose is weight-based, generally ranging from 20 to 100 mL/kg/day, with careful monitoring of fluid balance.
- Elderly and Patients with Renal/Cardiac Disease: Reduced volume and slower infusion rates are recommended to avoid fluid overload.
- Special Conditions: Dosage may vary in conditions such as burns, surgery, or metabolic disturbances, guided by ongoing clinical and laboratory evaluation.
- Infusion Rate: Should not exceed metabolic capacity to metabolize glucose (~4-6 mg/kg/min) to prevent hyperglycemia and osmotic diuresis.
Possible side effects of 2.5% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP
Although generally well tolerated, side effects can occur, especially if used improperly or in vulnerable populations.
- Common Side Effects:
- Infusion site irritation, pain, or phlebitis
- Mild fluid retention or peripheral edema
- Transient headaches or dizziness
- Serious Side Effects:
- Hyperglycemia, particularly in diabetic patients or if glucose metabolism is impaired
- Electrolyte disturbances such as hyponatremia or hypernatremia if improperly dosed
- Fluid overload leading to pulmonary edema, especially in cardiac or renal impairment
- Thrombophlebitis or vascular complications at infusion site
- Rare Allergic Reactions: Rash, itching, or very rarely anaphylaxis
2.5% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP Contraindications 2.5% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP
The infusion should be avoided or used cautiously in patients with certain medical conditions.
- Known hypersensitivity to any component of the infusion.
- Hyperglycemia or uncontrolled diabetes mellitus: Additional glucose may worsen hyperglycemia.
- Hypernatremia or fluid overload states: Use may exacerbate volume overload or increase sodium levels.
- Severe renal impairment or anuria: Risk of fluid retention and electrolyte imbalance.
- Intracranial or intraspinal hemorrhage: Hyperosmolar solutions like dextrose may worsen cerebral edema.
- Severe dehydration with hyperosmolarity: Risk of osmotic shifts causing complications.
Storage of 2.5% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP
Proper storage conditions are essential to maintain the safety and efficacy of the infusion solution.
- Store the solution at controlled room temperature, preferably below 25°C (77°F).
- Protect from direct sunlight, heat sources, and freezing conditions, as these can degrade the solution.
- Ensure the plastic bottle remains sealed and intact; do not use if the container is damaged or shows signs of leakage.
- Use before the expiration date printed on the label; do not use expired solutions.
- After opening, use immediately and discard any unused portion to avoid contamination and infection risk.
- Handle under aseptic conditions during preparation and administration to maintain sterility.
2.5% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP features an exceptional active ingredient renowned for its potent effects, comprising Dextrose (anhydrous), Sodium chloride. This powerful formulation provides a superior solution for addressing diverse health concerns. With 25mg, 4.5mg/ml concentration and an easily manageable Infusion/Solution for, it remains a preferred option for countless individuals seeking effective treatment.
Introduction
All you need to know about 2.5% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP .
Welcome to Dwaey, specifically on 2.5% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP page.
This medicine contains an important and useful components, as it consists of Dextrose (anhydrous), Sodium chloride.
2.5% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP is available in the market in concentration 25mg, 4.5mg/ml and in the form of Infusion/Solution for.
QATAR PHARMA is the producer of 2.5% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP and it is imported from QATAR,
The most popular alternatives of 2.5% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP are listed downward .
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Active Substance
Dextrose (anhydrous), Sodium chloride
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Frequently Asked Questions
2.5% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP should be stored according to the instructions provided by QATAR PHARMA.
In general, it is recommended to store 2.5% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP in a cool, dry place, away from direct sunlight
and out of the reach of children.
The duration of treatment with 2.5% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP may vary depending on the condition being treated
and the guidance of your healthcare provider. It is important to follow the prescribed treatment
plan and continue taking 2.5% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP for the recommended duration, even if your symptoms improve.
If you have any concerns or questions about the duration of treatment, consult your healthcare provider.
It is important to check with your healthcare provider or read the medication label for specific
instructions regarding alcohol consumption while taking 2.5% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP. Some medications, including
2.5% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP, may have interactions with alcohol that can reduce effectiveness, increase side
effects, or pose other risks to your health. It is best to follow the guidance provided by your
healthcare professional.
If you miss a dose of 2.5% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP, take it as soon as you remember. However, if it is close
to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing
schedule. Do not take a double dose to make up for a missed one unless advised by your healthcare provider.
No, do not stop taking 2.5% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP without consulting your healthcare provider, even if your
symptoms improve. It is important to complete the full course of treatment as prescribed. Stopping
the medication prematurely may lead to a relapse or incomplete resolution of the condition. If you
have concerns about the duration of treatment, consult your healthcare provider for guidance.
It is important to consult your healthcare provider before taking 2.5% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP if you are
pregnant or breastfeeding. They will be able to assess the potential risks and benefits based on your
specific situation. Please note that the safety and suitability of 2.5% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP during pregnancy
or breastfeeding may depend on the active substance [Active Substance], concentration 25mg, 4.5mg/ml,
and the specific recommendations of QATAR PHARMA.
The effects of 2.5% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP on your ability to drive or operate machinery can vary depending on
the active substance [Active Substance], concentration 25mg, 4.5mg/ml, and individual factors.
Some medications may cause drowsiness, dizziness, or other side effects that can impair your judgment
or coordination. It is important to read the medication label or consult your healthcare provider to
understand any potential effects on your ability to perform tasks that require alertness.
The instructions for taking 2.5% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP with or without food may vary depending on the medication
and the recommendations of QATAR PHARMA. Some medications may be more effective when taken with
food to enhance absorption or reduce stomach irritation, while others may need to be taken on an empty
stomach for optimal absorption. Read the medication label or consult your healthcare provider for specific instructions.
The use of 2.5% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP in children or elderly individuals may depend on various factors, including
the specific medication, type Infusion/Solution for, and the recommendations of QATAR PHARMA. Some
medications may have specific dosing instructions or precautions for these age groups. Consult your
healthcare provider or read the medication label for information regarding the safe and appropriate use
of 2.5% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP in children or elderly individuals.
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All medical information published on the Dwaey website aims to increase medical awareness and health education among users. However, it is not a substitute for professional medical advice. Always consult with a specialist doctor. We strongly advise against using any information or medicine found on the site without referring to your healthcare provider.
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