What is 10% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP
10% Dextrose & 0.45% Sodium Chloride Injection USP is a sterile, non-pyrogenic intravenous solution supplied in a 1000ml plastic bag. It is designed for fluid replenishment, electrolyte balance, and caloric supplementation in patients requiring parenteral support.
- Dextrose 10% (w/v): Provides readily metabolizable glucose, essential in patients with increased energy needs or at risk of hypoglycemia.
- Sodium Chloride 0.45% (w/v): Offers a hypotonic saline solution that supplies sodium and chloride, crucial for maintaining extracellular fluid balance and cellular function.
It is typically used in clinical settings for:
- Fluid maintenance in fasting or post-operative patients.
- Correcting moderate dehydration with concurrent caloric needs.
- Preventing ketosis during periods of low oral intake.
- Providing a dual source of hydration and energy.
How to use 10% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP
Proper use is vital to ensure efficacy and patient safety. The following practices are recommended:
- Ensure the solution is clear, and the bag is free from leaks or damage before use.
- Use aseptic technique to connect the bag to an IV line or infusion pump.
- Infuse intravenously, typically through a peripheral or central venous catheter.
- Adjust the infusion rate based on patient condition, age, weight, and ongoing fluid losses.
- Monitor fluid balance, electrolytes, and glucose levels regularly during use.
Avoid using with incompatible drugs and ensure any additives are mixed properly if introduced. This solution is not intended for intramuscular or subcutaneous injection.
Mode of Action 10% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP
The therapeutic action of this combination is based on two main components:
- Dextrose: Metabolized to carbon dioxide and water via glycolysis and the Krebs cycle, dextrose provides essential calories. It helps prevent protein catabolism and ketone production during fasting.
- Sodium Chloride: Helps replenish sodium losses and maintain plasma osmolality. It is vital for nerve conduction, muscle function, and acid-base balance.
The combination:
- Addresses both energy and electrolyte requirements in one solution.
- Supports patients in catabolic or post-operative states.
- Helps restore hydration while avoiding hypertonic sodium overload.
10% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP Interactions 10% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP
Drug interactions may occur when used concurrently with certain medications:
- Insulin: Enhances cellular uptake of glucose, potentially causing hypoglycemia if glucose intake is insufficient.
- Diuretics: Loop and thiazide diuretics may alter fluid and electrolyte balance.
- Steroids (e.g., prednisone): Can cause fluid retention and increase blood glucose levels.
- ACE inhibitors: May exacerbate hyperkalemia when sodium levels are altered.
- Digoxin: Electrolyte disturbances, especially hypokalemia or hypernatremia, can increase the risk of toxicity.
Careful monitoring of electrolytes and glucose is essential when combining with other systemic therapies.
Dosage of 10% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP
Dosage should be individualized based on the patient's age, weight, fluid and electrolyte needs, and clinical status.
- Adults: Commonly 1000–3000 ml/day, infused over 24 hours, adjusted as needed.
- Children: Typically dosed at 20–100 ml/kg/day, based on fluid and caloric requirements.
Important considerations:
- Use infusion pumps for controlled delivery.
- Monitor for signs of overhydration, such as edema or increased blood pressure.
- Adjust dosage in patients with renal, hepatic, or cardiac impairment.
Possible side effects of 10% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP
Like all intravenous solutions, this product may lead to side effects, especially if administered inappropriately or in susceptible individuals:
- Hyperglycemia: Especially in diabetic or insulin-resistant patients.
- Hyponatremia or hypernatremia: Depending on volume and electrolyte balance.
- Fluid overload: Can cause pulmonary or peripheral edema.
- Thrombophlebitis: Local irritation or vein inflammation at the infusion site.
- Hypokalemia: Dilutional effects may lead to potassium deficiency.
Immediate discontinuation and appropriate management are required in case of adverse reactions.
10% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP Contraindications 10% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP
Do not use this solution in the following situations:
- Severe hyperglycemia or diabetes mellitus without insulin regulation.
- Acute or chronic heart failure: Risk of fluid overload and pulmonary edema.
- Severe renal insufficiency: Inability to excrete excess sodium and fluid.
- Known hypersensitivity: To dextrose or sodium chloride.
- Fluid overload states: Such as ascites or generalized edema.
Use with extreme caution in elderly patients and those with impaired electrolyte homeostasis.
Storage of 10% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP
Proper storage maintains the integrity and sterility of the solution:
- Store at controlled room temperature between 15°C–25°C (59°F–77°F).
- Protect from excessive heat and direct sunlight.
- Do not freeze. Discard if the solution has been frozen.
- Inspect visually for clarity and container integrity before use.
- Use immediately after opening and discard any unused portion.
Follow institutional protocols for storage, handling, and disposal of parenteral solutions.
10% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP features an exceptional active ingredient renowned for its potent effects, comprising Dextrose (anhydrous), Sodium chloride. This powerful formulation provides a superior solution for addressing diverse health concerns. With 100mg, 4.5mg/ml concentration and an easily manageable Infusion/Solution for, it remains a preferred option for countless individuals seeking effective treatment.
Introduction
All you need to know about 10% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP .
Welcome to Dwaey, specifically on 10% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP page.
This medicine contains an important and useful components, as it consists of Dextrose (anhydrous), Sodium chloride.
10% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP is available in the market in concentration 100mg, 4.5mg/ml and in the form of Infusion/Solution for.
QATAR PHARMA is the producer of 10% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP and it is imported from QATAR,
The most popular alternatives of 10% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP are listed downward .
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Dextrose (anhydrous), Sodium chloride
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Frequently Asked Questions
10% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP should be stored according to the instructions provided by QATAR PHARMA.
In general, it is recommended to store 10% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP in a cool, dry place, away from direct sunlight
and out of the reach of children.
The duration of treatment with 10% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP may vary depending on the condition being treated
and the guidance of your healthcare provider. It is important to follow the prescribed treatment
plan and continue taking 10% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP for the recommended duration, even if your symptoms improve.
If you have any concerns or questions about the duration of treatment, consult your healthcare provider.
It is important to check with your healthcare provider or read the medication label for specific
instructions regarding alcohol consumption while taking 10% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP . Some medications, including
10% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP , may have interactions with alcohol that can reduce effectiveness, increase side
effects, or pose other risks to your health. It is best to follow the guidance provided by your
healthcare professional.
If you miss a dose of 10% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP , take it as soon as you remember. However, if it is close
to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing
schedule. Do not take a double dose to make up for a missed one unless advised by your healthcare provider.
No, do not stop taking 10% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP without consulting your healthcare provider, even if your
symptoms improve. It is important to complete the full course of treatment as prescribed. Stopping
the medication prematurely may lead to a relapse or incomplete resolution of the condition. If you
have concerns about the duration of treatment, consult your healthcare provider for guidance.
It is important to consult your healthcare provider before taking 10% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP if you are
pregnant or breastfeeding. They will be able to assess the potential risks and benefits based on your
specific situation. Please note that the safety and suitability of 10% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP during pregnancy
or breastfeeding may depend on the active substance [Active Substance], concentration 100mg, 4.5mg/ml,
and the specific recommendations of QATAR PHARMA.
The effects of 10% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP on your ability to drive or operate machinery can vary depending on
the active substance [Active Substance], concentration 100mg, 4.5mg/ml, and individual factors.
Some medications may cause drowsiness, dizziness, or other side effects that can impair your judgment
or coordination. It is important to read the medication label or consult your healthcare provider to
understand any potential effects on your ability to perform tasks that require alertness.
The instructions for taking 10% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP with or without food may vary depending on the medication
and the recommendations of QATAR PHARMA. Some medications may be more effective when taken with
food to enhance absorption or reduce stomach irritation, while others may need to be taken on an empty
stomach for optimal absorption. Read the medication label or consult your healthcare provider for specific instructions.
The use of 10% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP in children or elderly individuals may depend on various factors, including
the specific medication, type Infusion/Solution for, and the recommendations of QATAR PHARMA. Some
medications may have specific dosing instructions or precautions for these age groups. Consult your
healthcare provider or read the medication label for information regarding the safe and appropriate use
of 10% w/v DEXTROSE & 0.45% w/v SODIUM CHLORIDE INJECTION USP in children or elderly individuals.
Dwaey
All medical information published on the Dwaey website aims to increase medical awareness and health education among users. However, it is not a substitute for professional medical advice. Always consult with a specialist doctor. We strongly advise against using any information or medicine found on the site without referring to your healthcare provider.
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