DI-GEL (Lemon/Orange) Liquid (Oral)

What is DI-GEL (Lemon/Orange)

DI-GEL (Lemon/Orange) is an oral liquid medication formulated to relieve symptoms of heartburn, indigestion, upset stomach, and gas-related discomfort. It combines three active pharmaceutical ingredients:

• Aluminum Hydroxide – an antacid that neutralizes stomach acid.
• Magnesium Hydroxide – a fast-acting antacid that also helps prevent constipation caused by aluminum salts.
• Simethicone – an anti-foaming agent that breaks up gas bubbles in the gut.

DI-GEL is available in a flavored liquid suspension (lemon or orange) for easy ingestion and quick relief. It is commonly used to treat:

• Acid indigestion
• Heartburn
• Flatulence and bloating
• Gas pressure and discomfort

This product is suitable for adults and children over 12 years and is often recommended for symptomatic relief related to diet, stress, or gastrointestinal sensitivity.

How to use DI-GEL (Lemon/Orange)

Using DI-GEL correctly maximizes its benefits and reduces the risk of unwanted side effects. Follow these general guidelines or your healthcare provider’s advice:

• Shake Well: Always shake the bottle thoroughly before use to ensure uniform distribution of active ingredients.
• Measuring the Dose: Use a dosing cup or a calibrated medicine spoon. Avoid using household teaspoons, as they may lead to incorrect dosing.
• Timing:
  • Take DI-GEL after meals and at bedtime, or whenever symptoms occur.
  • May be taken with or without food.
• Swallow Slowly: For better mucosal coverage, slowly swallow the liquid and follow with a small sip of water if desired.
• Avoid Exceeding Dosage: Do not take more than the recommended amount without medical advice. Overuse can lead to side effects like constipation or electrolyte imbalance.

Consult a doctor if symptoms persist for more than two weeks or worsen. Long-term use without supervision may mask more serious gastrointestinal disorders.

Mode of Action DI-GEL (Lemon/Orange)

DI-GEL provides symptom relief through a synergistic mechanism involving three components that target different aspects of gastrointestinal discomfort.

• Aluminum Hydroxide:
  • Neutralizes gastric hydrochloric acid, reducing acidity in the stomach.
  • Forms aluminum chloride upon reacting with stomach acid, helping soothe the gastric lining.
  • Slower onset but longer-lasting antacid effect.
• Magnesium Hydroxide:
  • Acts rapidly to neutralize stomach acid.
  • Counteracts the constipating effects of aluminum by promoting a mild laxative effect.
• Simethicone:
  • Reduces surface tension of gas bubbles in the stomach and intestines.
  • Helps break up large gas bubbles into smaller ones, facilitating their passage and relieving bloating and pressure.
  • Does not affect gastric acidity, making it safe and effective in combination with antacids.

Together, these agents deliver rapid relief from heartburn, indigestion, and gas without significantly altering digestive functions or absorption processes.

DI-GEL (Lemon/Orange) Interactions DI-GEL (Lemon/Orange)

Although DI-GEL is available over-the-counter, it can interact with several prescription and non-prescription medications, primarily by affecting their absorption or activity.

• Antibiotics: May reduce the effectiveness of tetracyclines (e.g., doxycycline) and fluoroquinolones (e.g., ciprofloxacin). Separate administration by 2–4 hours.
• Thyroid Hormones: Can interfere with the absorption of levothyroxine. Take DI-GEL at least 4 hours apart.
• Iron Supplements: Absorption of oral iron (ferrous sulfate) may be reduced. Administer at different times.
• Bisphosphonates: Used for osteoporosis (e.g., alendronate) — antacids may hinder their bioavailability.
• Heart Medications: May alter the absorption of digoxin or propranolol. Monitor cardiac status and spacing of doses.
• Other Antacids or Laxatives: Using similar products concurrently may increase the risk of electrolyte imbalance or gastrointestinal side effects.

Always provide your healthcare provider with a complete list of medications and supplements you’re using before starting DI-GEL, especially if using it regularly.

Dosage of DI-GEL (Lemon/Orange)

Correct dosing is essential to achieve effective symptom relief while avoiding adverse effects. Below are standard guidelines for use:

• Adults and Children ≥12 Years:
  • Take 2 to 4 teaspoonfuls (10–20 mL) by mouth between meals, at bedtime, or as needed for symptoms.
  • Maximum dose: Do not exceed 12 teaspoonfuls (60 mL) in 24 hours unless directed by a physician.
• Children Under 12 Years:
  • Not typically recommended without medical supervision.
  • Pediatric use should be based on body weight and doctor’s advice.
• Method:
  • Shake the bottle well before each use.
  • Use a medical-grade measuring device to ensure correct dosing.
• Long-Term Use:
  • Should not be used continuously for more than two weeks unless under medical supervision.
  • Persistent symptoms may indicate an underlying condition that requires diagnosis.

Possible side effects of DI-GEL (Lemon/Orange)

DI-GEL is generally safe for most individuals when used as directed. However, certain side effects may occur, particularly with overuse or prolonged administration.

• Common Side Effects:
  • Constipation (from aluminum)
  • Diarrhea (from magnesium)
  • Mild nausea or stomach upset
• Less Common Side Effects:
  • Chalky taste in the mouth
  • Dry mouth or belching
• Serious Side Effects (Rare):
  • Electrolyte imbalance (especially in those with kidney issues)
  • Hypermagnesemia or aluminum toxicity (typically with chronic high-dose use)
  • Allergic reactions (rash, itching, swelling)

Seek immediate medical help if serious side effects such as confusion, irregular heartbeat, or muscle weakness occur. Patients with kidney conditions are especially at risk and should use the product only under supervision.

DI-GEL (Lemon/Orange) Contraindications DI-GEL (Lemon/Orange)

Certain conditions and factors may preclude the safe use of DI-GEL. In such cases, alternative therapies should be considered or medical supervision is required.

• Renal Dysfunction: Individuals with impaired kidney function should avoid products containing aluminum and magnesium due to accumulation and potential toxicity.
• Hypophosphatemia: Aluminum-based antacids can further lower phosphate levels, potentially causing weakness, fatigue, and bone demineralization.
• Appendicitis or Intestinal Obstruction: Symptoms like abdominal pain and bloating may mask more serious conditions.
• Allergic Reactions: Known hypersensitivity to any component, including flavorings or preservatives.
• Chronic GI Disorders: Persistent GI symptoms should be evaluated by a physician before using antacids long term.
• Pediatric Use: Not recommended for young children unless under physician guidance due to altered physiology and risk of electrolyte disturbance.

Discuss all medical history and medications with your provider before using DI-GEL, especially if you have existing chronic illnesses or are pregnant or breastfeeding.

Storage of DI-GEL (Lemon/Orange)

Proper storage of DI-GEL ensures the stability, efficacy, and safety of the product over time. Follow these guidelines:

• Temperature: Store at controlled room temperature, between 15°C and 30°C (59°F to 86°F).
• Avoid Freezing: Do not freeze the suspension. If frozen, discard the product.
• Protect from Light: Store in the original bottle with cap tightly closed, away from direct sunlight or heat sources.
• Keep Out of Reach of Children: Store in a safe place to prevent accidental ingestion.
• Shake Before Use: As a suspension, the product needs to be well shaken each time before dosing.
• Check Expiry Date: Discard any product that is past its expiration or appears discolored, separated, or altered in texture.

Following these storage instructions helps maintain the product’s integrity and ensures safe use throughout its shelf life.