(BAXTER) Sodium Chloride 0.45% w/v and Glucose 5.0% w/v Solution for infusion

What is (BAXTER) Sodium Chloride 0.45% w/v and Glucose 5.0% w/v

BAXTER Sodium Chloride 0.45% w/v and Glucose 5.0% w/v is a sterile, non-pyrogenic, dual-purpose infusion solution intended for intravenous administration. It is used to provide both fluid and electrolyte replenishment as well as caloric support. The sodium chloride component helps maintain electrolyte balance, while glucose supplies energy. This formulation is particularly beneficial for patients requiring rehydration with simultaneous nutritional supplementation.

• Form: Solution for infusion
• Contents per 100 ml: 0.45 g Sodium Chloride and 5 g Glucose
• Pack Size: 20 bags × 500 ml (Viaflo bags)
• Additional Nutrients: Often used in conjunction with Calcium Carbonate, Calcium Lactate Gluconate, Vitamin C, and Vitamin D3 for metabolic balance and bone health

This solution is commonly used in hospitals for patients suffering from mild to moderate dehydration, fasting, or recovery from surgery. It serves as a supportive fluid in electrolyte therapy and is ideal for those who cannot meet their nutritional needs orally.

How to use (BAXTER) Sodium Chloride 0.45% w/v and Glucose 5.0% w/v

This solution is administered intravenously and should be used under the direct supervision of a healthcare provider. The method of administration depends on the clinical condition and age of the patient.

• Administration Route: Intravenous infusion using sterile IV equipment
• Infusion Rate: Adjusted according to patient needs; often 100–200 ml/hour in adults
• Pre-Use Inspection: Check bag integrity, clarity, and absence of particulate matter
• Mixing with Additives: Calcium Carbonate, Vitamin C, and Vitamin D3 can be co-administered separately; ensure compatibility if mixing

The solution must be infused slowly, especially in patients with renal or cardiac conditions. Always monitor blood glucose, electrolytes, and hydration status throughout the therapy. For patients requiring specific nutrients, separate infusions or sequential administration may be necessary to avoid precipitation or incompatibility.

Mode of Action (BAXTER) Sodium Chloride 0.45% w/v and Glucose 5.0% w/v

This combination works by addressing both fluid-electrolyte imbalances and caloric needs. The sodium chloride component restores extracellular sodium and chloride levels, while the glucose component serves as a readily available energy source for cellular metabolism.

• Sodium (Na⁺): Maintains extracellular fluid volume, aids in nerve impulse transmission
• Chloride (Cl⁻): Supports acid-base homeostasis and osmotic pressure
• Glucose: Supplies metabolic energy and prevents ketosis during periods of starvation or fasting
• With Calcium & Vitamins: Supports musculoskeletal health, immune function, and enzymatic activity

The hypotonic sodium content ensures gentle rehydration, while glucose prevents catabolism. When co-administered with calcium and vitamin formulations, the therapy supports bone mineralization, antioxidant function, and overall metabolic health, especially in patients with nutritional deficiencies or chronic illnesses.

(BAXTER) Sodium Chloride 0.45% w/v and Glucose 5.0% w/v Interactions (BAXTER) Sodium Chloride 0.45% w/v and Glucose 5.0% w/v

This solution can interact with other medications and nutrients, particularly when used in combination therapies. Drug compatibility should always be verified prior to co-administration.

• Calcium Carbonate/Lactate Gluconate: Risk of precipitation if mixed in the same line; administer sequentially
• Vitamin C (Ascorbic Acid): Generally compatible, but high doses may increase renal oxalate load
• Vitamin D3: Synergistic effect with calcium on bone metabolism; monitor calcium levels to avoid hypercalcemia
• Insulin or Oral Hypoglycemics: May require dose adjustment due to the glucose content of the solution
• Diuretics or Corticosteroids: May affect sodium balance and fluid retention

Pharmacodynamic interactions must be considered, especially in patients receiving multiple infusions. Blood chemistry and glucose levels should be monitored to prevent metabolic disturbances. Incompatibility or co-precipitation risks should be managed by flushing lines between infusions.

Dosage of (BAXTER) Sodium Chloride 0.45% w/v and Glucose 5.0% w/v

Dosage should be individualized based on patient-specific factors such as age, weight, clinical status, and laboratory values. The goal is to correct fluid imbalances while maintaining energy supply.

• Adults: 500–2000 ml/day depending on hydration and nutritional requirements
• Pediatrics: 20–50 ml/kg/day, adjusted based on age and metabolic needs
• Infusion Rate: Typically 100–200 ml/hour in adults; slower in pediatric or cardiac patients
• Special Populations: Patients with renal or hepatic impairment require close monitoring and reduced volume

The infusion rate should be reduced in the presence of fluid overload or electrolyte imbalance. In critical care, this solution may serve as a basal infusion, while nutritional supplementation is administered parenterally. Monitor glucose and electrolyte levels routinely to ensure safe administration.

Possible side effects of (BAXTER) Sodium Chloride 0.45% w/v and Glucose 5.0% w/v

Though generally well tolerated, side effects may occur with improper administration, rapid infusion, or prolonged use. Monitoring can help prevent most complications.

• Common Side Effects:
• Mild swelling or edema
• Injection site reactions like redness or phlebitis
• Changes in serum sodium or glucose levels
• Serious Side Effects:
• Hyperglycemia or hypoglycemia
• Electrolyte imbalance (e.g., hyponatremia, hyperchloremia)
• Volume overload leading to pulmonary edema
• Rare Reactions: Allergic responses to additives, metabolic alkalosis (if given in large amounts)

Patients with diabetes, renal dysfunction, or congestive heart failure are at higher risk for adverse effects. Promptly discontinue the infusion if severe symptoms occur and initiate appropriate corrective treatment.

(BAXTER) Sodium Chloride 0.45% w/v and Glucose 5.0% w/v Contraindications (BAXTER) Sodium Chloride 0.45% w/v and Glucose 5.0% w/v

This solution should be avoided in patients with certain pre-existing conditions where hypotonic glucose solutions could cause harm.

• Severe Hyponatremia or Water Intoxication: May worsen electrolyte imbalance
• Uncontrolled Diabetes Mellitus: Risk of exacerbating hyperglycemia
• Severe Renal Impairment: May lead to fluid overload and impaired glucose clearance
• Acute Pulmonary Edema or Congestive Heart Failure: Increased risk of volume overload
• Known hypersensitivity: To any solution component or added nutrients

Use with caution in pregnant or breastfeeding women, and only when clinically indicated. In surgical or ICU settings, this product must be integrated into a broader fluid and nutritional management plan, especially when combining with calcium or vitamin-based therapies.

Storage of (BAXTER) Sodium Chloride 0.45% w/v and Glucose 5.0% w/v

Proper storage ensures the safety, efficacy, and sterility of this IV infusion solution.

• Storage Temperature: Store below 25°C; do not freeze
• Light Protection: Keep in original overwrap to protect from light
• Bag Integrity: Do not use if the container is damaged, leaking, or shows signs of contamination
• Shelf Life: Use before the expiration date printed on the label
• Post-Opening: Use immediately after opening; discard unused portions

Store in a clean, dry environment away from direct heat sources. Do not mix with other medications unless compatibility is confirmed. Dispose of in accordance with institutional or local biomedical waste protocols.