DFEROL 50 Capsules (Soft Gelatin)

What is DFEROL 50

DFEROL 50 is a soft gelatin capsule formulation containing Cholecalciferol (Vitamin D3), an essential fat-soluble vitamin required for calcium and phosphorus homeostasis in the body. Each capsule typically provides 50,000 IU of Vitamin D3, making it a high-dose supplement used in the prevention and treatment of vitamin D deficiency or insufficiency.

• Class: Nutritional Supplement / Vitamin
• Primary Ingredient: Cholecalciferol (Vitamin D3)
• Common Uses: Treatment of Vitamin D deficiency, support in osteoporosis, rickets, osteomalacia, and certain autoimmune conditions.
• Form: Soft gelatin capsule for oral use

DFEROL 50 is often prescribed for individuals who have low vitamin D levels due to inadequate dietary intake, limited sun exposure, malabsorption syndromes, or certain medical conditions.

How to use DFEROL 50

DFEROL 50 should be taken exactly as prescribed by your healthcare provider. Due to its high potency, it is usually administered weekly or biweekly depending on the indication and the patient’s serum vitamin D levels.

• Take the capsule orally with water, preferably with a meal to enhance absorption.
• Do not crush or chew the capsule.
• Adherence to the prescribed dosing schedule is crucial to avoid overdose or toxicity.
• Regular monitoring of serum calcium and vitamin D levels may be advised during prolonged therapy.

Always follow the instructions provided on the label or by your physician. If a dose is missed, take it as soon as you remember, unless it’s almost time for the next dose—do not double up.

Mode of Action DFEROL 50

Cholecalciferol (Vitamin D3), the active ingredient in DFEROL 50, functions primarily by regulating calcium and phosphate metabolism in the body. Once ingested, it undergoes conversion in the liver to 25-hydroxycholecalciferol, and then in the kidneys to its active form, 1,25-dihydroxycholecalciferol (calcitriol).

• Promotes calcium absorption in the intestine.
• Facilitates calcium and phosphate reabsorption in the kidneys.
• Stimulates bone mineralization and helps maintain proper skeletal structure.
• Modulates immune response and has anti-inflammatory effects.

Through these mechanisms, DFEROL 50 helps in correcting hypocalcemia, improving bone health, and supporting various biological functions influenced by vitamin D levels.

DFEROL 50 Interactions DFEROL 50

Cholecalciferol can interact with a range of medications, influencing their efficacy or increasing the risk of side effects.

• Thiazide Diuretics (e.g., hydrochlorothiazide): May increase the risk of hypercalcemia.
• Anticonvulsants (e.g., phenytoin, phenobarbital): May reduce vitamin D levels by increasing its metabolism.
• Glucocorticoids: Can reduce calcium absorption and impair vitamin D metabolism.
• Cholestyramine or Orlistat: May impair absorption of fat-soluble vitamins including vitamin D.
• Digoxin: High vitamin D levels can increase the risk of digitalis toxicity due to elevated calcium levels.

Always inform your doctor or pharmacist about all medications or supplements you are taking to avoid potential interactions.

Dosage of DFEROL 50

The dosage of DFEROL 50 depends on the patient's age, baseline vitamin D levels, and the severity of deficiency. The capsule delivers a high dose of 50,000 IU of Cholecalciferol, typically used for short-term correction of deficiency.

• Adults: 50,000 IU once weekly for 6–8 weeks followed by a maintenance dose (e.g., 1,000–2,000 IU daily or as advised).
• Elderly: Similar to adult dosing but with greater monitoring due to age-related changes in metabolism.
• Children and Adolescents: Use only if prescribed by a pediatric specialist, with adjusted dosage.

Do not exceed the prescribed dose. Periodic monitoring of serum 25(OH)D levels and calcium is recommended to assess response and avoid toxicity.

Possible side effects of DFEROL 50

DFEROL 50 is generally well tolerated when taken as prescribed. However, excessive or prolonged intake can lead to vitamin D toxicity, especially in individuals with underlying health conditions.

• Common: Nausea, constipation, headache, fatigue, dry mouth
• Less common: Hypercalcemia (high calcium levels), presenting with symptoms like:
  • Muscle weakness
  • Bone pain
  • Confusion or disorientation
  • Increased thirst or urination
• Rare: Allergic reactions (rash, itching, swelling, dizziness)

Seek medical attention if any signs of allergic reaction or persistent adverse symptoms occur. Regular follow-up may help mitigate risks.

DFEROL 50 Contraindications DFEROL 50

DFEROL 50 should not be used in certain conditions where vitamin D metabolism is impaired or excess calcium levels are already present.

• Known hypersensitivity to cholecalciferol or any excipients in the capsule.
• Hypercalcemia (high blood calcium levels).
• Hypervitaminosis D – a condition of excessive vitamin D in the body.
• Severe renal impairment or nephrolithiasis (kidney stones).
• Sarcoidosis or other granulomatous disorders – may increase sensitivity to vitamin D.

Always consult your healthcare provider before starting the supplement, especially if you have any chronic medical condition.

Storage of DFEROL 50

Proper storage of DFEROL 50 ensures its efficacy and prevents degradation of the active ingredient.

• Store at room temperature between 15°C to 25°C (59°F to 77°F).
• Keep away from direct sunlight, heat, and moisture.
• Do not refrigerate or freeze.
• Keep out of reach of children.
• Do not use after the expiry date printed on the package.

Always store in its original packaging to protect from light and preserve stability.