DEXTROKUF 15mg/5ml Syrup

What is DEXTROKUF 15mg/5ml

DEXTROKUF 15mg/5ml is a cough suppressant syrup containing Dextromethorphan Hydrobromide as its active ingredient. It is primarily used to relieve dry, irritating, non-productive coughs associated with conditions such as the common cold, bronchitis, or other respiratory illnesses. Dextromethorphan works by acting on the brain's cough center to reduce the urge to cough without affecting respiratory function significantly.

• Generic Name: Dextromethorphan Hydrobromide
• Form: Syrup
• Size: 100ml glass bottle
• Primary Use: Symptomatic relief of persistent, dry coughs

Unlike expectorants, which help bring up mucus, Dextrokuf suppresses the cough reflex, making it suitable for treating dry coughs that interfere with sleep or daily activities.

How to use DEXTROKUF 15mg/5ml

Correct usage of DEXTROKUF 15mg/5ml ensures optimal effectiveness and reduces the risk of side effects:

• Dosage Measurement: Always use a proper measuring spoon or cup. Do not use household teaspoons as they may not provide the correct dose.
• Administration: The syrup should be taken by mouth, with or without food. If gastrointestinal upset occurs, it can be taken with food or milk.
• Frequency: Administer the syrup exactly as prescribed by a healthcare provider, usually every 4–6 hours as needed for cough control.
• Avoid Overuse: Do not exceed the prescribed frequency or dosage, as high doses can lead to serious side effects.
• Hydration: Drinking plenty of fluids while on Dextrokuf may help loosen mucus in the lungs.

Always read the label carefully and consult a doctor if cough persists for more than 7 days, returns, or is accompanied by fever, rash, or persistent headache.

Mode of Action DEXTROKUF 15mg/5ml

DEXTROKUF 15mg/5ml acts centrally on the cough reflex:

• Central Cough Suppressant: Dextromethorphan is a non-opioid derivative that suppresses the cough reflex by directly acting on the medulla oblongata (specifically, the cough center of the brain).
• NMDA Receptor Antagonism: It also acts as a low-affinity antagonist at the N-methyl-D-aspartate (NMDA) receptors, which may contribute to its cough-suppressing effects without significant sedative or analgesic effects.
• No Respiratory Depression: Unlike opioids like codeine, dextromethorphan, when used at therapeutic doses, does not cause respiratory depression or addiction.

This dual action allows it to effectively control dry cough without affecting breathing patterns, making it safer for a wide range of patients when used appropriately.

DEXTROKUF 15mg/5ml Interactions DEXTROKUF 15mg/5ml

DEXTROKUF 15mg/5ml can interact with various medications, requiring caution:

• Monoamine Oxidase Inhibitors (MAOIs): Concurrent use (or within 14 days of stopping an MAOI) can cause serious, life-threatening reactions like serotonin syndrome.
• Selective Serotonin Reuptake Inhibitors (SSRIs): Co-administration increases the risk of serotonin syndrome symptoms like agitation, confusion, and tremors.
• Other CNS Depressants (alcohol, antihistamines, sedatives): May enhance drowsiness, dizziness, and risk of overdose.
• Antidepressants: Combining with tricyclic antidepressants or SNRIs can further increase the risk of serotonin toxicity.

Always inform your healthcare provider of all medications, including over-the-counter drugs and supplements, before starting Dextrokuf therapy.

Dosage of DEXTROKUF 15mg/5ml

The typical dosing of DEXTROKUF 15mg/5ml depends on the age and clinical needs of the patient:

• Adults and Children over 12 years: 10–20 mg every 4 hours as needed, or 30 mg every 6–8 hours. Maximum dose: 120 mg/day.
• Children 6–12 years: 5–10 mg every 4 hours as needed, or 15 mg every 6–8 hours. Maximum dose: 60 mg/day.
• Children under 6 years: Use is not generally recommended unless prescribed by a physician due to the risk of side effects.

Never exceed the maximum recommended daily dose, and use only as directed by a healthcare professional to prevent accidental overdose, particularly in children.

Possible side effects of DEXTROKUF 15mg/5ml

DEXTROKUF 15mg/5ml is generally well-tolerated when used properly but can cause side effects:

• Common Side Effects:
  • Drowsiness
  • Dizziness
  • Nausea or vomiting
  • Upset stomach
• Less Common Side Effects:
  • Confusion or disorientation
  • Excitation (particularly in children)
  • Agitation or nervousness
• Serious Side Effects (Rare):
  • Allergic reactions (rash, itching, swelling)
  • Breathing difficulties
  • Serotonin syndrome (especially with other serotonergic drugs)

Seek immediate medical help if any signs of a serious allergic reaction or serotonin syndrome develop.

DEXTROKUF 15mg/5ml Contraindications DEXTROKUF 15mg/5ml

Use of DEXTROKUF 15mg/5ml is contraindicated in the following situations:

• Hypersensitivity: Allergy to dextromethorphan or any component of the formulation.
• Concurrent Use with MAOIs: Risk of hypertensive crisis or serotonin syndrome.
• Severe Respiratory Conditions: Such as chronic bronchitis, emphysema, or asthma unless specifically prescribed and monitored.
• Children under 6 years old: Unless directed by a healthcare provider.

Careful evaluation of the patient’s health history is essential before initiating treatment.

Storage of DEXTROKUF 15mg/5ml

Proper storage is crucial to maintain the quality and effectiveness of DEXTROKUF 15mg/5ml:

• Temperature: Store at room temperature between 20°C and 25°C (68°F and 77°F).
• Light Protection: Keep the bottle tightly closed and protected from direct sunlight.
• Keep Out of Reach: Store away from children to prevent accidental ingestion.
• Do Not Freeze: Freezing may degrade the formulation.
• Expiration: Discard the syrup after the expiry date mentioned on the bottle label.

Shake the bottle well before each use and replace the cap tightly after dosing to ensure product integrity.