What is DEXTRAN (40) 10% w/v in Normal Saline
DEXTRAN (40) 10% w/v in Normal Saline is a sterile, non-pyrogenic solution composed of Dextran 40 (10%) and Sodium Chloride (0.9%) in water for injection. It is primarily used as a plasma volume expander in cases of hypovolemia, typically caused by blood loss or shock. Dextran 40 is a low-molecular-weight polysaccharide that helps maintain blood volume and pressure when plasma volume is depleted. The isotonic saline component assists in restoring electrolyte balance.
- Generic Name: Dextran 40 10% + Sodium Chloride 0.9%
- Form: Infusion solution
- Size: 500ml plastic bottle
- Primary Indications: Hypovolemia, shock, low blood volume, prevention of thrombosis, and during surgeries to support circulation.
It is commonly used in emergency and surgical settings to quickly stabilize patients suffering from volume depletion and to prevent complications related to low blood flow, such as clot formation.
How to use DEXTRAN (40) 10% w/v in Normal Saline
The administration of DEXTRAN (40) 10% w/v in Normal Saline must be done with care and under medical supervision:
- Route: Intravenous (IV) infusion only.
- Preparation: Ensure that the solution is clear and free from particles before use. Do not use if the solution is discolored or contains precipitates.
- Administration: Connect the bottle to a sterile IV set. Infuse at a controlled rate as directed by the healthcare provider based on the patient’s hemodynamic status and fluid needs.
- Monitoring: Continuous monitoring of vital signs (blood pressure, heart rate, oxygen saturation) and urine output during administration is crucial.
- Special Considerations: An initial small test dose may be given to monitor for hypersensitivity reactions before administering the full volume.
Proper aseptic techniques should be used throughout to avoid infection. Always adhere to the prescribed flow rate and volume to minimize the risk of complications such as fluid overload.
Mode of Action DEXTRAN (40) 10% w/v in Normal Saline
DEXTRAN (40) 10% w/v in Normal Saline acts through several mechanisms:
- Volume Expansion: Dextran 40 molecules increase plasma osmotic pressure, drawing fluid into the vascular compartment and thereby expanding blood volume.
- Improved Microcirculation: By reducing blood viscosity, dextran improves microcirculatory blood flow and oxygen delivery to tissues.
- Antithrombotic Effect: Dextran inhibits platelet aggregation and decreases blood viscosity, helping to prevent thrombus (clot) formation in vulnerable patients.
- Electrolyte Balance: Sodium chloride in the solution helps maintain isotonicity and corrects any concurrent electrolyte disturbances, particularly hyponatremia.
Overall, Dextran 40 serves to rapidly restore circulatory stability in critically ill patients while providing some protection against thrombosis.
DEXTRAN (40) 10% w/v in Normal Saline Interactions DEXTRAN (40) 10% w/v in Normal Saline
Certain medications and medical conditions can interact with DEXTRAN (40) 10% w/v in Normal Saline:
- Anticoagulants (e.g., Heparin, Warfarin): Additive effects may increase bleeding risk.
- Diuretics (e.g., Furosemide): Concurrent use requires caution to avoid electrolyte imbalance and kidney dysfunction.
- Blood products: Mixing dextran with blood in the same infusion set without proper flushing can cause clot formation.
- Hypertonic or Hypotonic Solutions: Concurrent use with non-isotonic fluids should be carefully controlled to avoid shifts in osmolarity.
Always inform the healthcare provider about all ongoing treatments before starting infusion therapy with dextran-containing solutions to avoid adverse interactions.
Dosage of DEXTRAN (40) 10% w/v in Normal Saline
Dosage must be individualized based on the patient’s clinical condition:
- Typical Initial Dose: 500 mL infused over 1 to 2 hours for acute volume replacement.
- Maintenance Dose: Additional 250-500 mL depending on the patient’s hemodynamic response and fluid requirements.
- Maximum Daily Dose: Generally should not exceed 20 mL/kg/day of Dextran 40 to avoid renal overload and risk of bleeding.
- Infusion Rate: Should be carefully controlled, typically not exceeding 10 mL/minute during initial infusion stages.
Always adjust infusion based on clinical response, ongoing blood losses, urine output, and laboratory parameters such as hematocrit and electrolytes.
Possible side effects of DEXTRAN (40) 10% w/v in Normal Saline
While generally effective and well-tolerated, DEXTRAN (40) 10% w/v in Normal Saline can cause adverse effects:
- Common Side Effects:
- Volume overload (pulmonary edema, hypertension)
- Peripheral edema
- Mild allergic reactions (rash, itching)
- Serious Side Effects:
- Severe anaphylactic reactions (rare but potentially life-threatening)
- Bleeding tendencies (due to anti-platelet effects)
- Kidney dysfunction (especially with excessive doses)
- Electrolyte disturbances (hypernatremia, hyperchloremia)
Immediate medical attention is necessary if any signs of anaphylaxis (difficulty breathing, swelling of the face or throat) or pulmonary edema develop during or after the infusion.
DEXTRAN (40) 10% w/v in Normal Saline Contraindications DEXTRAN (40) 10% w/v in Normal Saline
Use of DEXTRAN (40) 10% w/v in Normal Saline is contraindicated in the following conditions:
- Severe Congestive Heart Failure: Risk of exacerbating fluid overload.
- Severe Renal Dysfunction or Anuria: Dextran is excreted by the kidneys; impaired renal function can lead to toxicity.
- Known Hypersensitivity to Dextran: Risk of severe allergic reaction.
- Severe Hemorrhagic Conditions: Risk of enhanced bleeding due to platelet inhibition.
- Uncontrolled Hypertension: Volume expansion can worsen high blood pressure.
Always perform a thorough clinical assessment before initiating therapy with dextran solutions.
Storage of DEXTRAN (40) 10% w/v in Normal Saline
Proper storage conditions are vital for maintaining the efficacy and safety of DEXTRAN (40) 10% w/v in Normal Saline:
- Temperature: Store between 15°C and 25°C (59°F and 77°F).
- Light Protection: Protect from excessive light exposure.
- Do Not Freeze: Freezing may compromise the integrity of the solution.
- Handling: Use only if the solution is clear and free from particulate matter. Do not use if cloudy or if the container is damaged.
- Shelf-life: Follow the manufacturer’s expiration date. Do not use beyond the expiry date printed on the packaging.
After opening, any unused portion should be discarded to prevent contamination and infection risks.
DEXTRAN (40) 10% w/v in Normal Saline features an exceptional active ingredient renowned for its potent effects, comprising Dextran 40 / Sodium chloride. This powerful formulation provides a superior solution for addressing diverse health concerns. With 100mg, 9mg/ml concentration and an easily manageable Infusion/Solution for, it remains a preferred option for countless individuals seeking effective treatment.
DEXTRAN (40) 10% w/v in Normal Saline
LMD (dextran 40) is a sterile, nonpyrogenic preparation of low molecular weight dextran (average mol. wt. 40,000) in 5% Dextrose Injection or 0.9% Sodium Chloride Injection. It is administered by intravenous infusion.
CONTRAINDICATIONS of DEXTRAN (40)
LMD (dextran 40) is contraindicated in patients with known hypersensitivity to dextran, in those with marked hemostatic defects of all types (thrombocytopenia, hypofibrinogenemia, etc.) including those caused by drugs (heparin, warfarin, etc.), marked cardiac decompensation and in renal disease with severe oliguria or anuria.
INDICATIONS AND USAGE of DEXTRAN (40)
LMD (dextran 40) is indicated for use in the adjunctive treatment of shock or impending shock due to hemorrhage, burns, surgery or other trauma. It is not indicated as a replacement for whole blood or blood components if they are available. It should not replace other forms of therapy known to be of value in the treatment of shock.
LMD is also indicated for use as a priming fluid, either as a sole prime or as an additive, in pump oxygenators during extracorporeal circulation.
LMD is also indicated for use in prophylaxis of venous thrombosis and pulmonary embolism in patients undergoing procedures known to be associated with a high incidence of thromboembolic complications, such as hip surgery.
Introduction
All you need to know about DEXTRAN (40) 10% w/v in Normal Saline .
Welcome to Dwaey, specifically on DEXTRAN (40) 10% w/v in Normal Saline page.
This medicine contains an important and useful components, as it consists of Dextran 40 / Sodium chloride.
DEXTRAN (40) 10% w/v in Normal Saline is available in the market in concentration 100mg, 9mg/ml and in the form of Infusion/Solution for.
KUWAIT SAUDI PHARMACEUTICAL INDUSTRIES CO. (KSPICO) is the producer of DEXTRAN (40) 10% w/v in Normal Saline and it is imported from KUWAIT,
The most popular alternatives of DEXTRAN (40) 10% w/v in Normal Saline are listed downward .
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Active Substance
Dextran 40 / Sodium chloride
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Size
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Indications
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Type
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Company
KUWAIT SAUDI PHARMACEUTICAL INDUSTRIES CO. (KSPICO)
Frequently Asked Questions
DEXTRAN (40) 10% w/v in Normal Saline should be stored according to the instructions provided by KUWAIT SAUDI PHARMACEUTICAL INDUSTRIES CO. (KSPICO).
In general, it is recommended to store DEXTRAN (40) 10% w/v in Normal Saline in a cool, dry place, away from direct sunlight
and out of the reach of children.
The duration of treatment with DEXTRAN (40) 10% w/v in Normal Saline may vary depending on the condition being treated
and the guidance of your healthcare provider. It is important to follow the prescribed treatment
plan and continue taking DEXTRAN (40) 10% w/v in Normal Saline for the recommended duration, even if your symptoms improve.
If you have any concerns or questions about the duration of treatment, consult your healthcare provider.
It is important to check with your healthcare provider or read the medication label for specific
instructions regarding alcohol consumption while taking DEXTRAN (40) 10% w/v in Normal Saline. Some medications, including
DEXTRAN (40) 10% w/v in Normal Saline, may have interactions with alcohol that can reduce effectiveness, increase side
effects, or pose other risks to your health. It is best to follow the guidance provided by your
healthcare professional.
If you miss a dose of DEXTRAN (40) 10% w/v in Normal Saline, take it as soon as you remember. However, if it is close
to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing
schedule. Do not take a double dose to make up for a missed one unless advised by your healthcare provider.
No, do not stop taking DEXTRAN (40) 10% w/v in Normal Saline without consulting your healthcare provider, even if your
symptoms improve. It is important to complete the full course of treatment as prescribed. Stopping
the medication prematurely may lead to a relapse or incomplete resolution of the condition. If you
have concerns about the duration of treatment, consult your healthcare provider for guidance.
It is important to consult your healthcare provider before taking DEXTRAN (40) 10% w/v in Normal Saline if you are
pregnant or breastfeeding. They will be able to assess the potential risks and benefits based on your
specific situation. Please note that the safety and suitability of DEXTRAN (40) 10% w/v in Normal Saline during pregnancy
or breastfeeding may depend on the active substance [Active Substance], concentration 100mg, 9mg/ml,
and the specific recommendations of KUWAIT SAUDI PHARMACEUTICAL INDUSTRIES CO. (KSPICO).
The effects of DEXTRAN (40) 10% w/v in Normal Saline on your ability to drive or operate machinery can vary depending on
the active substance [Active Substance], concentration 100mg, 9mg/ml, and individual factors.
Some medications may cause drowsiness, dizziness, or other side effects that can impair your judgment
or coordination. It is important to read the medication label or consult your healthcare provider to
understand any potential effects on your ability to perform tasks that require alertness.
The instructions for taking DEXTRAN (40) 10% w/v in Normal Saline with or without food may vary depending on the medication
and the recommendations of KUWAIT SAUDI PHARMACEUTICAL INDUSTRIES CO. (KSPICO). Some medications may be more effective when taken with
food to enhance absorption or reduce stomach irritation, while others may need to be taken on an empty
stomach for optimal absorption. Read the medication label or consult your healthcare provider for specific instructions.
The use of DEXTRAN (40) 10% w/v in Normal Saline in children or elderly individuals may depend on various factors, including
the specific medication, type Infusion/Solution for, and the recommendations of KUWAIT SAUDI PHARMACEUTICAL INDUSTRIES CO. (KSPICO). Some
medications may have specific dosing instructions or precautions for these age groups. Consult your
healthcare provider or read the medication label for information regarding the safe and appropriate use
of DEXTRAN (40) 10% w/v in Normal Saline in children or elderly individuals.
Dwaey
All medical information published on the Dwaey website aims to increase medical awareness and health education among users. However, it is not a substitute for professional medical advice. Always consult with a specialist doctor. We strongly advise against using any information or medicine found on the site without referring to your healthcare provider.
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