DEXKEVITAE 25mg Tablets/Film-coated

What is DEXKEVITAE 25mg

DEXKEVITAE 25mg is a non-steroidal anti-inflammatory drug (NSAID) containing Dexketoprofen as its active ingredient. It is designed for short-term relief of mild to moderate pain, such as musculoskeletal pain, dental pain, dysmenorrhea (painful menstruation), and post-operative pain. Dexketoprofen is the active enantiomer of ketoprofen, meaning it offers potent analgesic and anti-inflammatory effects at lower doses with potentially fewer gastrointestinal side effects compared to racemic ketoprofen.

• Generic Name: Dexketoprofen
• Form: Film-coated Tablets
• Strength: 25 mg per tablet
• Packaging: 20 tablets (10s blister pack × 2)
• Indications: Relief of musculoskeletal pain, dental pain, menstrual pain, post-operative pain, and other acute painful conditions.

DEXKEVITAE 25mg acts quickly, usually providing noticeable pain relief within 30 minutes after oral administration.

How to use DEXKEVITAE 25mg

To achieve the best therapeutic results with minimal side effects, follow these guidelines when using DEXKEVITAE 25mg:

• Route: Oral administration.
• Timing: Ideally taken before meals to enhance its effectiveness; however, if gastrointestinal discomfort occurs, it can be taken with food.
• Capsule Handling: Swallow the tablet whole with a sufficient amount of water. Do not crush, split, or chew the tablet.
• Consistency: Use the minimum effective dose for the shortest duration necessary to control symptoms.
• Missed Dose: If a dose is missed, take it as soon as possible. If it is near the time of the next dose, skip the missed dose. Do not double up to make up for a missed one.

Always follow your physician’s instructions carefully. Do not exceed the recommended dose without medical advice to avoid the risk of adverse reactions.

Mode of Action DEXKEVITAE 25mg

DEXKEVITAE 25mg works by inhibiting the production of substances in the body that cause pain and inflammation:

• COX Inhibition: Dexketoprofen selectively inhibits cyclooxygenase (COX) enzymes, particularly COX-2, reducing the formation of prostaglandins, which are chemical mediators involved in pain, inflammation, and fever.
• Rapid Onset: Due to its high solubility and rapid absorption, dexketoprofen offers quick analgesic effects, typically noticeable within 30 minutes of ingestion.
• Short Half-life: It has a relatively short half-life (~1-2 hours), allowing for flexible dosing schedules and reduced accumulation in the body.

This mechanism makes DEXKEVITAE effective for acute pain management with rapid relief, especially beneficial in conditions requiring quick onset of action.

DEXKEVITAE 25mg Interactions DEXKEVITAE 25mg

Several medications can interact with DEXKEVITAE 25mg, potentially affecting its efficacy or increasing the risk of adverse effects:

• Anticoagulants (e.g., Warfarin): Increased risk of bleeding due to additive anticoagulant effects.
• Antiplatelet Agents (e.g., Aspirin, Clopidogrel): Enhanced risk of gastrointestinal bleeding.
• Other NSAIDs or Corticosteroids: Concurrent use increases the risk of gastrointestinal ulcers and bleeding.
• Diuretics (e.g., Furosemide): Reduced diuretic and antihypertensive effect, risk of nephrotoxicity.
• ACE Inhibitors and ARBs: Possible increased risk of kidney impairment when used with NSAIDs.
• SSRIs (e.g., Sertraline): Increased risk of gastrointestinal bleeding.
• Lithium: Risk of elevated lithium levels and toxicity.

Always inform your healthcare provider of all prescription, non-prescription drugs, and supplements you are taking before starting DEXKEVITAE 25mg.

Dosage of DEXKEVITAE 25mg

Standard dosing instructions for DEXKEVITAE 25mg are:

• Adults: 12.5 mg every 4-6 hours or 25 mg every 8 hours as needed for pain control.
• Maximum Daily Dose: Do not exceed 75 mg per day.
• Short-Term Use: Recommended for short-term treatment (typically no longer than a few days).
• Special Populations:
  • Use with caution and lower dosing in elderly patients.
  • Patients with mild to moderate renal or hepatic impairment may require dosage adjustment or increased monitoring.

Use the lowest effective dose for the shortest period consistent with treatment goals to minimize risks.

Possible side effects of DEXKEVITAE 25mg

While effective, DEXKEVITAE 25mg may cause some side effects:

• Common Side Effects:
  • Nausea
  • Dyspepsia (indigestion)
  • Abdominal pain
  • Diarrhea
  • Headache
  • Dizziness
• Less Common Side Effects:
  • Flatulence
  • Constipation
  • Somnolence (sleepiness)
  • Skin rash
• Serious Side Effects (rare):
  • Gastrointestinal bleeding or ulcers
  • Severe allergic reactions (anaphylaxis, angioedema)
  • Kidney dysfunction
  • Severe skin reactions (Stevens-Johnson syndrome)

If any severe reactions occur, discontinue the medication and seek immediate medical attention.

DEXKEVITAE 25mg Contraindications DEXKEVITAE 25mg

Use of DEXKEVITAE 25mg is contraindicated in the following situations:

• Hypersensitivity: Allergy to dexketoprofen, other NSAIDs, or any excipients in the formulation.
• Active Peptic Ulcer or Gastrointestinal Bleeding: NSAIDs can exacerbate bleeding or perforation.
• Severe Heart Failure: NSAIDs can cause fluid retention and worsen heart failure.
• Severe Renal or Hepatic Impairment: Risk of further organ damage.
• Asthma: NSAID-exacerbated respiratory disease (NERD).
• Pregnancy and Lactation: Particularly contraindicated in the third trimester.

Careful patient selection and risk assessment are crucial before initiating treatment with DEXKEVITAE 25mg.

Storage of DEXKEVITAE 25mg

Proper storage ensures DEXKEVITAE’s effectiveness and safety:

• Temperature: Store below 25°C (77°F).
• Humidity: Keep in a dry place, away from moisture and heat sources.
• Packaging: Keep the tablets in the original blister pack until use to protect them from light and humidity.
• Child Safety: Store out of reach of children.
• Expiration: Do not use the medicine beyond the expiry date printed on the packaging. Dispose of expired products safely.

Following storage guidelines ensures that DEXKEVITAE remains potent and safe to use throughout its shelf life.