DEXASALYL Ointment

What is DEXASALYL

DEXASALYL is a topical ointment that combines two active ingredients: Dexamethasone acetate, a potent corticosteroid, and Salicylic acid, a keratolytic agent. It is commonly used for the treatment of various skin conditions that involve inflammation, scaling, and hyperkeratosis.

• Dexamethasone acetate: A synthetic corticosteroid that reduces inflammation, redness, and itching by suppressing the immune response in the skin.
• Salicylic acid: A beta-hydroxy acid that promotes the shedding of the outer layer of the skin (keratolytic action), softens scales, and enhances the penetration of other topical medications.
• Form: Ointment
• Packaging: 20g Tube

DEXASALYL is particularly useful in treating conditions such as psoriasis, eczema, seborrheic dermatitis, chronic dermatitis, and other inflammatory skin disorders where thickening or scaling of the skin is present.

How to use DEXASALYL

To achieve the best therapeutic outcomes, DEXASALYL should be used exactly as prescribed by your healthcare provider. Here is a general guideline for its proper use:

• Wash and dry the affected area thoroughly before applying the ointment. Use mild soap and water, and pat the area dry with a clean towel.
• Apply a thin layer of DEXASALYL to the affected area. Gently massage it into the skin until it is evenly distributed. Avoid using large amounts unless instructed by a healthcare professional.
• Frequency: Typically applied 1 to 2 times daily, depending on the severity of the condition and the doctor's recommendation.
• Avoid contact with eyes, mouth, and mucous membranes. If accidental contact occurs, rinse thoroughly with water.
• Do not cover the treated area with occlusive dressings unless directed by a physician. This may increase systemic absorption and risk of side effects.
• Wash your hands after each application unless you are treating your hands.

It is important not to use DEXASALYL for longer than prescribed, as prolonged use of corticosteroids can lead to skin thinning and other complications.

Mode of Action DEXASALYL

DEXASALYL works through a combination of anti-inflammatory and keratolytic mechanisms provided by its two active ingredients:

• Dexamethasone acetate:
  • Acts on intracellular glucocorticoid receptors to modulate gene expression.
  • Suppresses the production of pro-inflammatory cytokines and enzymes such as prostaglandins and leukotrienes.
  • Reduces capillary permeability, thereby minimizing local swelling and redness.
  • Inhibits immune cell migration to inflamed skin tissues, reducing immune-mediated damage.
• Salicylic acid:
  • Breaks down keratin, a protein that causes skin cells to stick together, thus promoting exfoliation.
  • Softens the outer skin layer, improving the penetration of dexamethasone.
  • Has mild antiseptic and anti-inflammatory effects that contribute to the healing process.

This dual action makes DEXASALYL especially effective for skin disorders that involve both inflammation and thickened, scaly skin.

DEXASALYL Interactions DEXASALYL

While DEXASALYL is a topical formulation and systemic absorption is limited, certain interactions may still occur, especially with prolonged or large-area use:

• Other topical corticosteroids: Concurrent use may increase the risk of cumulative skin thinning and systemic steroid effects.
• Topical retinoids or acne medications (e.g., tretinoin, benzoyl peroxide): May increase skin irritation when used with salicylic acid.
• Oral anticoagulants (e.g., warfarin): There may be a theoretical risk of enhanced anticoagulant effect due to systemic absorption of salicylic acid.
• Phototherapy: Using DEXASALYL before UV treatment may increase photosensitivity or reduce the effectiveness of phototherapy in conditions like psoriasis.
• Other keratolytic agents: Products containing urea, lactic acid, or sulfur may cause excessive peeling and irritation if used with salicylic acid.

Always inform your healthcare provider of all topical and systemic medications you are using to avoid potential interactions.

Dosage of DEXASALYL

The dosage of DEXASALYL should be individualized based on the severity and location of the skin condition, as well as patient response. Below are general guidelines:

• Recommended frequency: Apply a thin layer once or twice daily, or as directed by your healthcare provider.
• Amount per application: Enough ointment to cover the affected area with a thin, even film. A fingertip unit (about 0.5g) can treat an area the size of two adult hands.
• Maximum duration: Use should generally not exceed 2 consecutive weeks without medical supervision. Long-term use increases the risk of local and systemic corticosteroid side effects.
• Special populations:
  • Children: Use with caution and only under medical supervision, as they are more susceptible to systemic absorption and growth suppression.
  • Elderly: No specific adjustment is usually needed, but monitor for increased skin sensitivity.

Do not exceed the recommended dose, and consult your doctor if no improvement is seen after a few days of regular use.

Possible side effects of DEXASALYL

DEXASALYL is generally well tolerated when used as prescribed, but like all medications, it may cause side effects. These can be categorized into local and, rarely, systemic effects:

• Common local side effects:
  • Burning or stinging sensation at the application site
  • Redness or irritation
  • Dryness or peeling of skin
  • Itching or discomfort
• Less common side effects:
  • Skin thinning (atrophy)
  • Stretch marks (striae)
  • Increased hair growth in treated areas
  • Skin discoloration
• Rare but serious effects (usually with prolonged or extensive use):
  • Suppression of the hypothalamic-pituitary-adrenal (HPA) axis
  • Systemic corticosteroid side effects (e.g., mood changes, increased blood sugar)
  • Allergic contact dermatitis

If any signs of allergic reaction (e.g., rash, swelling, difficulty breathing) or worsening skin condition occur, discontinue use and seek medical attention immediately.

DEXASALYL Contraindications DEXASALYL

DEXASALYL should not be used in certain clinical scenarios due to the risk of adverse effects or lack of efficacy. Contraindications include:

• Hypersensitivity: Known allergy to dexamethasone, salicylic acid, or any component of the ointment base.
• Viral skin infections: Herpes simplex, varicella (chickenpox), or other viral dermatoses may worsen with corticosteroid use.
• Tubercular or fungal skin infections: Topical corticosteroids can exacerbate these infections and mask symptoms.
• Open wounds or broken skin: Increased absorption may occur, leading to systemic side effects.
• Use in infants: Not recommended due to increased percutaneous absorption and higher risk of systemic effects.
• Acne vulgaris or rosacea: Corticosteroids can aggravate these conditions.

Consult a healthcare professional before using DEXASALYL if you have any underlying conditions or are using other medications.

Storage of DEXASALYL

Proper storage of DEXASALYL is essential to maintain its stability, effectiveness, and safety. Follow these guidelines:

• Temperature: Store at room temperature, ideally between 15°C and 25°C (59°F and 77°F). Avoid exposure to heat or direct sunlight.
• Humidity: Keep in a dry place. Do not store in bathrooms where humidity is high.
• Keep container tightly closed: Always replace the cap securely after each use to prevent contamination and drying out of the ointment.
• Do not freeze: Freezing may alter the texture and effectiveness of the product.
• Keep out of reach of children: Accidental ingestion may be harmful.
• Check expiration date: Do not use past the expiry date printed on the tube or outer packaging.

Discard any unused medication safely as per your pharmacist's or local waste disposal guidelines. Do not flush it down the toilet or pour into drains.