DAIVONEX 50mcg/ml Scalp Solution

What is DAIVONEX 50mcg/ml

DAIVONEX 50 mcg/ml Scalp Solution is a topical dermatological treatment used primarily in the management of scalp psoriasis. It contains the active ingredient Calcipotriol, a synthetic derivative of vitamin D3. This solution is specifically formulated to treat the flaky, scaly, and inflamed lesions associated with plaque psoriasis localized on the scalp.

Psoriasis is a chronic, inflammatory skin condition characterized by rapid skin cell turnover, resulting in thickened patches of red, scaly skin. DAIVONEX helps restore the normal growth cycle of skin cells and reduces symptoms such as scaling, redness, and itching.

Key Features of DAIVONEX:

• Active Ingredient: Calcipotriol 50 mcg/ml
• Formulation: Alcohol-based clear solution suitable for the scalp
• Presentation: 30ml squeeze bottle for targeted, easy application
• Indicated for: Mild to moderate plaque psoriasis of the scalp

It is typically prescribed for short-term treatment and should be used under medical supervision, especially if combined with other topical agents or corticosteroids.

How to use DAIVONEX 50mcg/ml

Correct application of DAIVONEX Scalp Solution ensures effective results and minimizes the risk of side effects. It is a topical medicine and should not be ingested or used on the face.

Instructions for Use:

• Step 1: Shake the bottle gently before each use.
• Step 2: Apply the solution directly onto the affected areas of the scalp using the nozzle tip of the squeeze bottle.
• Step 3: Gently rub it into the scalp using clean fingers until fully absorbed.
• Step 4: Wash hands thoroughly after application to avoid accidental contact with the eyes or face.

Dos and Don’ts:

• Do not apply to the face, eyes, or broken/infected skin.
• Do not exceed the recommended dosage (usually no more than 60 ml/week).
• Avoid washing hair immediately after application; allow time for absorption.
• Do not use occlusive (airtight) dressings over the treated area unless directed by your doctor.

This product is for external use only and should be used exactly as directed by a healthcare professional.

Mode of Action DAIVONEX 50mcg/ml

DAIVONEX (Calcipotriol) acts by correcting the abnormal cell turnover seen in psoriasis. Calcipotriol is a synthetic analogue of vitamin D3 that regulates skin cell production and differentiation, which is typically disrupted in psoriatic skin.

Mechanism of Action:

• Modulation of Keratinocyte Growth: Calcipotriol binds to vitamin D receptors in skin cells, which slows down the excessive proliferation of keratinocytes, a hallmark of psoriasis.
• Normalization of Cell Differentiation: Helps restore the proper maturation of epidermal cells, reducing thick and scaly plaques.
• Anti-inflammatory Properties: Although not primarily an anti-inflammatory, Calcipotriol also has some immune-modulating effects that contribute to reducing local inflammation.

By targeting the underlying mechanisms of psoriasis rather than merely suppressing symptoms, DAIVONEX offers a non-steroidal option for long-term psoriasis management, particularly suitable for areas like the scalp where steroid use may be limited by safety concerns.

DAIVONEX 50mcg/ml Interactions DAIVONEX 50mcg/ml

DAIVONEX Scalp Solution is generally well tolerated, but it may interact with certain medications or topical products. Careful coordination with a healthcare provider is necessary when combining treatments.

Potential Drug Interactions:

• Topical Corticosteroids: Can be used in combination for improved effect but should be applied at different times of day (e.g., corticosteroid in the morning, Calcipotriol at night) to prevent interference.
• Systemic Vitamin D Supplements: Risk of hypercalcemia if large amounts of vitamin D analogs are used concurrently.
• Other Topical Psoriasis Treatments: Avoid mixing DAIVONEX with coal tar, salicylic acid, or other keratolytic agents directly on the skin, as they may inactivate Calcipotriol or irritate the skin.
• Phototherapy (UVB): Use with caution; Calcipotriol may enhance UV-induced skin sensitivity. If used concurrently, apply Calcipotriol after phototherapy, not before.

Precaution: Always inform your doctor or pharmacist about all the topical and systemic medications being used to ensure safety and therapeutic efficacy.

Dosage of DAIVONEX 50mcg/ml

The correct dosage of DAIVONEX Scalp Solution is essential to balance effectiveness with safety. This medication is potent and should be used according to prescribed guidelines.

Typical Adult Dosage:

• Apply to affected areas of the scalp twice daily (morning and evening), unless otherwise directed by your doctor.
• The total weekly dose should not exceed 60 ml of solution.

Duration of Use:

• Usually prescribed for 6 to 8 weeks, depending on response and tolerability.
• Chronic use beyond 8 weeks should be under medical supervision.

Dosage Adjustments:

• Elderly patients: No routine adjustment needed unless comorbidities exist.
• Children: Not typically recommended for children under 18 without specialist advice.

Overuse may lead to systemic absorption of Calcipotriol and risk of hypercalcemia, so adherence to dosage limits is crucial.

Possible side effects of DAIVONEX 50mcg/ml

DAIVONEX Scalp Solution is usually well-tolerated, but side effects can occur, especially with prolonged or improper use. Most are localized to the application site.

Common Side Effects (Mild):

• Itching, dryness, or irritation at the site of application
• Burning or stinging sensation shortly after use
• Redness or inflammation of the scalp

Less Common or Severe Reactions:

• Allergic contact dermatitis
• Worsening of psoriasis (psoriasis flare or pustular psoriasis)
• Skin discoloration or temporary hair texture change

Systemic Effects (Rare):

• Hypercalcemia: Occurs when the medication is overused or absorbed in excess; symptoms include fatigue, nausea, muscle weakness, and confusion.

When to Seek Medical Attention:

• Signs of allergy: swelling, rash, or difficulty breathing
• Worsening of skin condition or development of pustules
• Unexplained fatigue, confusion, or frequent urination (signs of calcium imbalance)

Report any persistent or severe side effects to your healthcare provider promptly.

DAIVONEX 50mcg/ml Contraindications DAIVONEX 50mcg/ml

DAIVONEX Scalp Solution should not be used in certain individuals due to the risk of adverse effects or ineffective treatment. Below are the key contraindications and precautions:

Absolute Contraindications:

• Known hypersensitivity to Calcipotriol or any ingredient in the formulation
• Patients with hypercalcemia or evidence of calcium metabolism disorders
• Severe hepatic or renal impairment, due to increased risk of systemic side effects

Relative Contraindications (Use with Caution):

• Use on the face or other sensitive areas is not recommended due to risk of irritation
• Children and adolescents: Safety and efficacy have not been well established
• Pregnancy and breastfeeding: Use only if the potential benefit justifies the potential risk to the fetus or infant

Always perform a risk-benefit assessment before starting therapy, particularly in patients with multiple comorbidities or those already using systemic therapies for psoriasis.

Storage of DAIVONEX 50mcg/ml

Proper storage of DAIVONEX Scalp Solution ensures that the product retains its efficacy and remains safe for use throughout its shelf life.

• Temperature: Store below 25°C (77°F). Do not freeze.
• Light Sensitivity: Protect from direct sunlight and UV exposure, which may degrade the active ingredient.
• Container: Keep the bottle tightly closed when not in use. Ensure the cap is secure to prevent evaporation or contamination.
• Position: Store the squeeze bottle upright to avoid leakage.
• Hygiene: Do not allow the nozzle to come into contact with the scalp directly to avoid contamination.
• Expiry: Do not use after the expiry date printed on the packaging. Discard any unused product after the recommended in-use period post opening (usually 3–6 months unless otherwise specified).

Keep out of reach of children and do not store near open flames or heat sources due to the alcohol content in the solution.