DESLADIN 5 mg Tablet/Film coated

What is DESLADIN 5 mg

DIPROGENTA Cream is a topical medication used primarily for the treatment of inflammatory skin conditions, particularly those that are complicated by bacterial infections. This cream contains a combination of two active ingredients: betamethasone dipropionate, a potent corticosteroid, and gentamicin sulfate, an aminoglycoside antibiotic. Betamethasone dipropionate is responsible for reducing inflammation, swelling, and itching by inhibiting the release of substances that cause these reactions in the body. On the other hand, gentamicin sulfate works by inhibiting bacterial protein synthesis, thereby preventing the growth and proliferation of bacteria.

By combining these two active ingredients, DIPROGENTA Cream is effective in treating a wide variety of dermatological conditions such as eczema, psoriasis, and dermatitis that are also at risk of bacterial infections. This dual-action approach ensures that the inflammatory symptoms are controlled while simultaneously treating or preventing any potential bacterial infection in the affected area.

It is important to understand that the use of DIPROGENTA Cream should be restricted to the areas of the skin affected by the conditions for which it was prescribed. Prolonged or inappropriate use of topical corticosteroids like betamethasone can lead to side effects, such as skin thinning or an increased risk of infection. Additionally, misuse of antibiotics like gentamicin can result in antibiotic resistance, which is a serious concern in both dermatological and systemic infections.

Clinical studies have demonstrated the efficacy of DIPROGENTA Cream in rapidly alleviating the symptoms of inflammatory skin conditions while effectively reducing the bacterial load in infected areas. Patients generally report a noticeable reduction in redness, swelling, and itching within a few days of initiating treatment.

However, DIPROGENTA Cream is not suitable for use in viral or fungal skin infections, as its antibacterial action does not extend to these types of pathogens. Furthermore, corticosteroids may exacerbate certain viral infections such as herpes simplex, which can lead to complications.

It is also worth noting that patients who have hypersensitivity to either betamethasone, gentamicin, or any other components of the cream should avoid its use. Hypersensitivity reactions, although rare, can include severe skin irritation, rashes, and allergic contact dermatitis.

Due to the potent nature of the ingredients in DIPROGENTA Cream, its use should be closely monitored by a healthcare professional, especially in children or individuals with compromised immune systems. Understanding the mechanism of action and the appropriate usage of this cream can help ensure that it delivers maximum therapeutic benefit while minimizing potential risks.

How to use DESLADIN 5 mg

How to Use DIPROGENTA Cream: Proper application of DIPROGENTA Cream is crucial for achieving the desired therapeutic effects while minimizing the risk of side effects. The cream should only be used on the affected areas as directed by a healthcare provider, and patients should strictly adhere to the prescribed dosing schedule.

• Frequency of Application: Generally, DIPROGENTA Cream is applied once or twice daily, depending on the severity of the skin condition and the recommendation of the healthcare provider. Patients should not exceed the recommended frequency to avoid the risk of corticosteroid overuse and antibiotic resistance.
• Method of Application: Before applying the cream, the affected area should be gently cleaned and dried. A thin layer of the cream should then be applied evenly over the area and gently massaged into the skin. It is important to wash hands thoroughly after application to avoid accidentally transferring the cream to sensitive areas such as the eyes or mouth.
• Duration of Use: The duration of treatment with DIPROGENTA Cream depends on the condition being treated and the patients response to the medication. In most cases, it is used for a short period (generally no longer than two weeks), but the exact duration should be determined by the healthcare provider.
• Avoid Occlusive Dressings: Unless specifically directed by a healthcare provider, occlusive dressings (which can trap moisture and heat) should not be used over the area where the cream has been applied, as this can increase the absorption of betamethasone, potentially leading to systemic side effects.
• Avoid Application to Broken Skin: The cream should not be applied to areas of broken skin, as this can lead to increased absorption of the active ingredients and heighten the risk of systemic side effects, particularly with prolonged use.

Patients should be reminded not to use DIPROGENTA Cream for conditions other than those for which it was prescribed, and they should follow up with their healthcare provider if symptoms do not improve or worsen after a few days of treatment. Misuse or overuse of the cream can lead to complications such as skin thinning, discoloration, or the development of resistance to gentamicin.

Mode of Action DESLADIN 5 mg

Mechanism of Action: DIPROGENTA Cream functions through the combined effects of its two active ingredients—betamethasone dipropionate and gentamicin sulfate. Each of these ingredients targets different aspects of the inflammatory and infectious process to provide comprehensive relief from skin conditions that are complicated by bacterial infections.

• Betamethasone Dipropionate: Betamethasone dipropionate is a potent corticosteroid that works by inhibiting the production of inflammatory mediators such as prostaglandins and leukotrienes. These substances are normally released in response to injury or irritation and lead to the characteristic symptoms of inflammation, including redness, swelling, and itching. By blocking their production, betamethasone helps to quickly reduce these symptoms.
• Gentamicin Sulfate: Gentamicin sulfate is an antibiotic that belongs to the aminoglycoside class. It exerts its effect by binding to bacterial ribosomes and inhibiting protein synthesis. This action prevents the bacteria from growing and multiplying, ultimately leading to their death. Gentamicin is effective against a wide range of Gram-negative and Gram-positive bacteria, making it suitable for treating bacterial infections that complicate inflammatory skin conditions.
• Combined Action: The combination of these two active ingredients allows DIPROGENTA Cream to address both the inflammatory and infectious components of many dermatological conditions. While betamethasone reduces the inflammatory response, gentamicin ensures that any bacterial infection is simultaneously treated. This dual action makes DIPROGENTA Cream a versatile and effective treatment option for a range of skin conditions.

The synergistic effects of these two active ingredients ensure that DIPROGENTA Cream provides rapid relief from symptoms while also addressing the underlying bacterial infection, if present. This dual mechanism of action is particularly beneficial for patients whose skin conditions are at risk of becoming secondarily infected, as it eliminates the need for separate anti-inflammatory and antibiotic treatments.

DESLADIN 5 mg Interactions DESLADIN 5 mg

Drug Interactions with DIPROGENTA Cream: Although DIPROGENTA Cream is applied topically, there is a potential for interactions with other medications, particularly when used over large areas of the skin or for prolonged periods.

• Other Topical Corticosteroids: The concurrent use of multiple topical corticosteroids can increase the risk of systemic corticosteroid side effects, such as adrenal suppression or skin thinning. Patients should avoid using other steroid-containing creams unless directed by their healthcare provider.
• Systemic Antibiotics: While the risk of interactions with systemic antibiotics is low, caution should be exercised if the patient is also receiving aminoglycoside antibiotics, such as gentamicin injections or oral medications, to avoid exceeding safe levels of the drug in the body.
• Immunosuppressive Agents: Patients using immunosuppressive medications, such as methotrexate or cyclosporine, should inform their healthcare provider before using DIPROGENTA Cream, as the corticosteroid component may increase the risk of infections and other complications.
• Herbal Supplements: Some herbal supplements, such as St. John's Wort, may affect the metabolism of corticosteroids and should be used with caution. Patients should inform their healthcare provider of any supplements they are taking.

While the risk of systemic drug interactions with DIPROGENTA Cream is relatively low due to its topical nature, it is still important for patients to provide a complete list of all medications they are taking, including prescription drugs, over-the-counter products, and herbal supplements. This will help healthcare providers assess the potential for any interactions and ensure that DIPROGENTA Cream is used safely.

Dosage of DESLADIN 5 mg

Dosage and Administration of DIPROGENTA Cream: The recommended dosage of DIPROGENTA Cream depends on the severity of the condition being treated and the response to the medication. However, there are general guidelines that patients should follow to ensure proper use.

• Application Frequency: DIPROGENTA Cream is typically applied to the affected area once or twice daily. The exact frequency of application will depend on the severity of the condition and the recommendation of the healthcare provider. Patients should not apply the cream more frequently than prescribed to avoid increasing the risk of side effects.
• Amount of Cream: A thin layer of DIPROGENTA Cream should be applied to the affected area and gently massaged into the skin. Patients should avoid applying the cream in thick layers or using occlusive dressings unless directed by their healthcare provider.
• Duration of Use: The duration of treatment with DIPROGENTA Cream will vary depending on the condition being treated and the patient's response to the medication. In general, the cream should not be used for longer than two weeks without reassessment by a healthcare provider.
• Missed Doses: If a dose is missed, the patient should apply it as soon as they remember. However, if it is almost time for the next scheduled dose, the missed dose should be skipped to avoid over-application.

Patients should follow the dosing instructions provided by their healthcare provider and should not adjust their dosage without consulting their healthcare provider. Misuse or overuse of the cream can lead to adverse effects, including skin thinning and bacterial resistance.

Possible side effects of DESLADIN 5 mg

Side Effects of DIPROGENTA Cream: Like all medications, DIPROGENTA Cream can cause side effects. Most side effects are localized to the area where the cream is applied and are generally mild. However, systemic side effects may occur, particularly when the cream is used over large areas of the skin, under occlusive dressings, or for extended periods.

• Local Side Effects: Common local side effects of DIPROGENTA Cream include skin irritation, burning, itching, and redness at the site of application. These side effects are usually mild and resolve on their own once the cream is discontinued. However, if the irritation persists or worsens, patients should contact their healthcare provider.
• Skin Thinning: Prolonged use of corticosteroids, such as betamethasone, can lead to skin thinning, a condition known as atrophy. This side effect is more likely to occur when the cream is used on delicate areas of the skin, such as the face or groin, or when occlusive dressings are used.
• Systemic Side Effects: Although rare, systemic side effects can occur, particularly when the cream is used over large areas of the skin or for long periods. These side effects may include adrenal suppression, hyperglycemia (elevated blood sugar levels), and Cushing's syndrome (a condition characterized by weight gain, high blood pressure, and a round face).
• Allergic Reactions: In rare cases, patients may develop an allergic reaction to one of the ingredients in DIPROGENTA Cream. Symptoms of an allergic reaction include severe itching, rash, swelling, and difficulty breathing. Patients who experience these symptoms should seek medical attention immediately.

Patients should be aware of the potential side effects of DIPROGENTA Cream and should report any unusual or persistent symptoms to their healthcare provider. In most cases, the benefits of using DIPROGENTA Cream to treat inflammatory skin conditions outweigh the potential risks, particularly when the cream is used as directed.

DESLADIN 5 mg Contraindications DESLADIN 5 mg

Information not available.

Storage of DESLADIN 5 mg

Storage Instructions for DIPROGENTA Cream: Proper storage of DIPROGENTA Cream is essential to ensure the stability and effectiveness of the medication. Patients should follow these guidelines to ensure that the cream remains safe and effective for use throughout its shelf life.

• Temperature: DIPROGENTA Cream should be stored at room temperature, away from direct heat or sunlight. It is important to avoid exposing the cream to extreme temperatures, as this can affect its potency and stability.
• Moisture: The cream should be stored in a dry place, away from moisture and humidity. Exposure to moisture can cause the cream to degrade and lose its effectiveness.
• Container: DIPROGENTA Cream should be kept in its original container with the cap tightly closed when not in use. This helps to protect the cream from contamination and moisture.
• Expiration Date: Patients should always check the expiration date on the packaging before using DIPROGENTA Cream. If the cream has expired, it should not be used, as it may no longer be effective and could potentially cause harm.
• Keep Out of Reach of Children: As with all medications, DIPROGENTA Cream should be stored out of the reach of children to prevent accidental ingestion or misuse.

By following these storage guidelines, patients can help ensure that DIPROGENTA Cream remains safe and effective for use throughout the duration of treatment. Improper storage can reduce the potency of the cream and increase the risk of complications.