DELSTRIGO Tablets/Film-coated

What is DELSTRIGO

DELSTRIGO is a combination antiretroviral medication used in the treatment of HIV-1 infection in adults. It contains three active ingredients: Doravirine, Lamivudine, and Tenofovir disoproxil fumarate, which work together to suppress the replication of HIV in the body. This combination helps to reduce the amount of HIV in the blood (viral load) and increases the number of CD4+ cells (immune cells), helping to improve immune function and decrease the risk of HIV-related complications.

Doravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI), which blocks the HIV enzyme reverse transcriptase, preventing the virus from copying its genetic material and replicating. Lamivudine and Tenofovir disoproxil fumarate are nucleoside reverse transcriptase inhibitors (NRTIs), which also target the reverse transcriptase enzyme, but through a different mechanism of action. Together, these drugs provide a powerful barrier to HIV replication.

DELSTRIGO comes in the form of film-coated tablets, packaged in an HDPE bottle containing 30 tablets. It is designed to be taken once daily, simplifying the treatment regimen for individuals with HIV. While DELSTRIGO is effective in managing HIV, it is not a cure for the infection. It should be used as part of a comprehensive treatment plan that includes regular monitoring and adherence to the prescribed regimen to maintain viral suppression and prevent resistance.

How to use DELSTRIGO

How to take DELSTRIGO:

• Take one tablet of DELSTRIGO once daily, exactly as prescribed by your healthcare provider. It can be taken with or without food.
• Swallow the tablet whole with water. Do not split, chew, or crush the tablet, as this may affect how the medication is absorbed by your body.
• If you miss a dose of DELSTRIGO, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take two doses at once.
• Adhere to your prescribed schedule, as skipping doses or stopping treatment may lead to an increase in viral load and resistance to the medication.

It is crucial to continue taking DELSTRIGO as directed, even if you feel well. Consistent use helps to maintain viral suppression and supports long-term health. If you experience side effects or difficulty adhering to the regimen, consult your healthcare provider for advice on how to manage these issues.

Mode of Action DELSTRIGO

Mode of action of DELSTRIGO:

• Doravirine (NNRTI): Doravirine works by binding to the reverse transcriptase enzyme, which is essential for the HIV virus to copy its RNA into DNA. By inhibiting this enzyme, Doravirine prevents the virus from replicating and spreading in the body.
• Lamivudine (NRTI): Lamivudine is incorporated into the viral DNA by reverse transcriptase, but it acts as a faulty building block. This prevents the HIV virus from forming complete DNA chains, halting replication.
• Tenofovir disoproxil fumarate (NRTI): Similar to Lamivudine, Tenofovir disoproxil is also incorporated into the viral DNA, leading to premature chain termination. This further disrupts the viruss ability to multiply.

By targeting reverse transcriptase through two different mechanisms (NNRTI and NRTI), DELSTRIGO provides a potent triple-action approach to preventing HIV replication. This combined effect reduces the viral load, helps to restore immune function, and prevents the progression of HIV-related diseases. Regular use of DELSTRIGO, along with other antiretroviral agents, is necessary to maintain control over HIV infection.

DELSTRIGO Interactions DELSTRIGO

Interactions with DELSTRIGO:

• Other Antiretrovirals: Combining DELSTRIGO with other antiretroviral medications may lead to drug interactions that could either reduce the effectiveness of treatment or increase the risk of side effects. Consult your healthcare provider before taking any other HIV medications alongside DELSTRIGO.
• Medications for Other Conditions: Some medications, including those used to treat seizures (e.g., carbamazepine), tuberculosis (e.g., rifampin), and certain fungal infections (e.g., ketoconazole), can interact with DELSTRIGO, affecting how it is metabolized in the body. Be sure to inform your doctor of all medications you are taking.
• Herbal Supplements: Herbal products like St. John’s Wort may reduce the effectiveness of DELSTRIGO by increasing the breakdown of the active ingredients, leading to decreased blood levels of the medication.

It is important to provide your healthcare provider with a complete list of all medications, including over-the-counter drugs and supplements, to avoid potential interactions. Your healthcare provider may adjust your dosage or monitor for side effects if interactions are a concern.

Dosage of DELSTRIGO

Dosage of DELSTRIGO:

The standard dosage of DELSTRIGO is one tablet taken orally once daily. Each tablet contains 100 mg of Doravirine, 300 mg of Lamivudine, and 300 mg of Tenofovir disoproxil fumarate. It is important to follow your healthcare provider’s dosing instructions carefully and not alter the dosage without medical advice.

• Adults: One tablet should be taken once daily, with or without food. Consistency in taking the medication at the same time each day is important to maintain stable drug levels in the blood.
• Missed Dose: If you miss a dose of DELSTRIGO, take it as soon as you remember unless it is almost time for your next dose. Do not double the dose to make up for the missed one.

DELSTRIGO is not recommended for patients with certain types of kidney disease. Your healthcare provider may adjust your treatment if you have kidney or liver problems, or if you are taking other medications that affect these organs. Regular blood tests may be required to monitor your kidney function and overall health during treatment.

Possible side effects of DELSTRIGO

Possible side effects of DELSTRIGO:

Like all medications, DELSTRIGO may cause side effects, although not everyone experiences them. Common side effects include:

• Headache
• Nausea
• Diarrhea
• Dizziness
• Fatigue

More serious side effects can occur in some individuals, particularly with long-term use:

• Kidney problems: Tenofovir disoproxil can affect kidney function. Regular monitoring is required to detect early signs of kidney damage.
• Bone density loss: Tenofovir disoproxil may cause a decrease in bone mineral density, leading to an increased risk of fractures over time.
• Lactic acidosis: In rare cases, DELSTRIGO may cause lactic acidosis, a serious condition where too much lactic acid builds up in the blood. Symptoms include muscle pain, trouble breathing, and fatigue.

Contact your healthcare provider if you experience any severe or persistent side effects. If you develop symptoms of an allergic reaction, such as rash, swelling, or difficulty breathing, seek immediate medical attention.

DELSTRIGO Contraindications DELSTRIGO

Information not available.

Storage of DELSTRIGO

Storage of DELSTRIGO:

• Store DELSTRIGO in its original HDPE bottle at room temperature (between 20°C to 25°C), away from moisture and direct heat.
• Keep the bottle tightly closed when not in use and store it out of the reach of children and pets.
• Do not use the medication after the expiration date printed on the packaging. Dispose of any expired or unused medication according to local regulations.

If you are unsure how to dispose of unused or expired medication, consult your pharmacist for guidance. Proper storage helps maintain the effectiveness of the medication and ensures safety for you and your family.