Overview

Welcome to Dwaey, specifically on AVLOCAN 400 mg Tablet/Film-coated page.
This medicine contains an important and useful components, as it consists of Moxifloxacin .
AVLOCAN 400 mg is available in the market in concentration 400 mg/tablet and in the form of Tablet/Film-coated.

ADCAN PHARMA is the producer of AVLOCAN 400 mg and it is imported from UAE, The most popular alternatives of AVLOCAN 400 mg are listed downward .

Mode Of Action & Indication

Moxifloxacin inhibits the topoisomerase II (DNA gyrase) and topoisomerase IV required for bacterial DNA replication, transcription, repair and recombination.

Indication

• Intra-abdominal infections
• Chronic bronchitis
• Acute bacterial sinusitis
• Community-acquired pneumonia
• Skin and skin structure infections
• Typhoid Fever

Precaution

Maintain adequate fluid intake; Patient w/ previous tendon disorders (e.g. rheumatoid arthritis), significant bradycardia or acute myocardial ischaemia, heart failure w/ reduced LVEF, known history of symptomatic arrhythmias, known or suspected CNS disorders (e.g. severe cerebral arteriosclerosis, epilepsy) or other risk factors that predispose to seizures; diabetes. Kidney, heart or lung transplant recipients. Hepatic impairment. Pregnancy and lactation. Patient Counselling This drug may cause dizziness and lightheadedness, if affected do not drive or operate machinery. Rest and refrain from doing strenuous physical activity as it may increase risk of tendon rupture. Avoid exposure to sunlight or artificial UV light (e.g. tanning beds, UVA/UVB treatment) and use protective measures (e.g. sunscreen, wear loose-fitting clothes) if staying outdoors is necessary during therapy. Monitoring Parameters Monitor WBC and signs of infection.

Side Effects

• 1-10% Nausea (7%)
• Diarrhea (6%)
• Dizziness (3%)
• Decreased amylase (2%)
• Decreased basophils
• eosinophils
• hemoglobin
• prothrombin time
• red blood cells
• neutrophils (2%)
• Decreased serum glucose (2%)
• Increased serum chloride (2%)
• Increased serum ionized calcium (2%)
• Immune hypersensitivity reaction (0.1-2%)
• Prolonged QT interval (0.1-2%) <1% Acute renal failure
• Agranulocytosis
• Anaphylactoid reaction
• Aplastic anemia
• Extrinsic allergic alveolitis
• Hemolytic anemia
• Hepatic failure
• Hepatic necrosis
• Hepatitis
• Pancytopenia
• Seizure
• Serum sickness due to drug
• Stevens-Johnson syndrome
• Tendon rupture
• tendinitis
• Thrombocytopenia
• Torsades de pointes
• Toxic epidermal necrolysis

Contra indication

Known hypersensitivity to moxifloxacin, other quinolones. Patients w/ known prolongation of QT interval, uncorrected hypokalaemia, myasthenia gravis. Concurrent use of class Ia (e.g.quinidine, procainamide, class III (e.g. amiodarone, sotalol) antiarrhythmic drugs or w/ other drugs that prolong QT interval (e.g. erythromycin, TCAs, antipsychotic agents).

Pregnancy and lactation

Pregnancy category: C

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks