PANADOL SINUS RELIEF PE Tablets (Caplets)

What is PANADOL SINUS RELIEF PE

PANADOL SINUS RELIEF PE is a combination over-the-counter medication formulated to relieve symptoms associated with sinus congestion and cold. It comes in the form of caplets (tablets) and contains two active ingredients:

• Paracetamol (500 mg): A widely used analgesic (pain reliever) and antipyretic (fever reducer).
• Phenylephrine Hydrochloride (5 mg): A decongestant that helps relieve nasal and sinus congestion.

This medication is typically used for short-term relief of symptoms such as:

• Sinus headache and facial pain
• Nasal and sinus congestion
• Fever associated with cold or sinusitis
• Pressure and swelling in the sinuses

PANADOL SINUS RELIEF PE is suitable for adults and adolescents over 12 years old, and should be used as directed. It is not an antibiotic and does not treat the underlying infection if one is present.

How to use PANADOL SINUS RELIEF PE

Correct usage of PANADOL SINUS RELIEF PE ensures maximum effectiveness and reduces the risk of side effects. Always follow the instructions provided on the packaging or as directed by your healthcare provider.

• Dosage Frequency: Take 2 caplets every 4 to 6 hours as needed for relief.
• Maximum Daily Dose: Do not exceed 8 caplets in 24 hours.
• Swallow Whole: Caplets should be swallowed whole with water. Do not crush, chew, or break them.
• With or Without Food: Can be taken with or without food. Taking it after meals may reduce stomach discomfort.
• Duration of Use: Do not use for more than 3 consecutive days without medical advice.

Important Considerations:

• Do not use this medication in combination with other paracetamol-containing products to avoid overdose.
• Avoid taking this medication late in the day to prevent insomnia caused by phenylephrine.
• If symptoms persist or worsen, consult a healthcare professional.

Misuse or exceeding the recommended dose can result in serious liver damage (from paracetamol) or cardiovascular issues (from phenylephrine).

Mode of Action PANADOL SINUS RELIEF PE

PANADOL SINUS RELIEF PE combines two pharmacologically active compounds that work synergistically to relieve sinus-related discomfort:

• Paracetamol:
• Inhibits cyclooxygenase (COX) enzymes, primarily in the brain, which are involved in the synthesis of prostaglandins—chemicals that promote pain and fever.
• Reduces fever by acting on the hypothalamic heat-regulating center.
• Provides effective relief from headaches and facial pain associated with sinus pressure.
• Phenylephrine HCl:
• Acts as a selective alpha-1 adrenergic receptor agonist.
• Causes vasoconstriction (narrowing of blood vessels) in the nasal mucosa.
• This vasoconstriction reduces blood flow to the sinuses and nasal passages, leading to decreased swelling and mucus formation.

Together, these mechanisms help relieve sinus congestion and associated symptoms while addressing pain and fever.

PANADOL SINUS RELIEF PE Interactions PANADOL SINUS RELIEF PE

PANADOL SINUS RELIEF PE may interact with several medications, potentially altering their effects or increasing the risk of side effects.

• Other Paracetamol-Containing Products: Risk of liver damage due to cumulative paracetamol intake.
• MAO Inhibitors (e.g., phenelzine, tranylcypromine): May cause dangerous increases in blood pressure. Avoid using PANADOL SINUS RELIEF PE within 14 days of stopping an MAOI.
• Beta-Blockers (e.g., atenolol, metoprolol): May enhance the hypertensive effects of phenylephrine.
• Tricyclic Antidepressants (e.g., amitriptyline): Can also increase the risk of elevated blood pressure when combined with phenylephrine.
• Warfarin and Other Anticoagulants: Paracetamol may increase the risk of bleeding when taken regularly over a long period.
• Sympathomimetic Drugs: Combining with other decongestants or stimulants can amplify cardiovascular side effects.

Alcohol: Should be avoided as it may increase the risk of liver damage when taken with paracetamol.

Always consult your healthcare provider before using PANADOL SINUS RELIEF PE if you are on any long-term medications or have a chronic health condition.

Dosage of PANADOL SINUS RELIEF PE

Correct dosage ensures the medicine’s effectiveness while minimizing risks.

• Adults and Children Over 12 Years: Take 2 caplets every 4 to 6 hours as needed.
• Maximum Dose: No more than 8 caplets in a 24-hour period.
• Children Under 12: Not recommended unless advised by a doctor.

Special Populations:

• Elderly: Use with caution. Start with the lowest effective dose due to potential sensitivity to side effects.
• Hepatic Impairment: Use is contraindicated or should be done under strict medical supervision due to the risk of liver toxicity from paracetamol.
• Renal Impairment: Use with caution; dosing intervals may need to be adjusted.

Never exceed the recommended dose or frequency. If you miss a dose, take it as soon as you remember, but skip it if the next dose is near.

Possible side effects of PANADOL SINUS RELIEF PE

While PANADOL SINUS RELIEF PE is generally well tolerated, side effects can occur, especially if used improperly or in sensitive individuals.

• Common Side Effects:
• Nausea or stomach upset
• Headache
• Nervousness or restlessness (due to phenylephrine)
• Insomnia
• Less Common Side Effects:
• Increased blood pressure
• Palpitations
• Dizziness
• Dry mouth or throat
• Serious but Rare Side Effects:
• Allergic reactions (rash, swelling, difficulty breathing)
• Liver damage from paracetamol overdose
• Heart rhythm disturbances (especially in those with pre-existing conditions)

Stop taking the medication and seek immediate medical help if any signs of allergic reactions or liver toxicity (e.g., yellowing of skin, dark urine, extreme fatigue) appear.

PANADOL SINUS RELIEF PE Contraindications PANADOL SINUS RELIEF PE

PANADOL SINUS RELIEF PE should not be used in certain individuals due to the potential risk of severe adverse effects.

• Known Allergy: Hypersensitivity to paracetamol, phenylephrine, or any other ingredients in the formulation.
• Severe Hypertension: Phenylephrine may exacerbate high blood pressure.
• Severe Coronary Artery Disease: Decongestants can cause vasoconstriction, worsening cardiac symptoms.
• Use of MAO Inhibitors: Do not use if currently or recently (within 14 days) using monoamine oxidase inhibitors due to hypertensive risk.
• Severe Hepatic Impairment: High risk of liver damage from paracetamol.

Use with Caution:

• In individuals with thyroid disease, diabetes, or glaucoma
• Pregnant or breastfeeding women (only under medical advice)

Always consult your doctor before using this medication if you have chronic illnesses or are on multiple medications.

Storage of PANADOL SINUS RELIEF PE

Proper storage helps maintain the medication’s efficacy and safety.

• Temperature: Store below 25°C (77°F). Avoid exposure to high heat or humidity.
• Packaging: Keep in original blister packaging until use to protect from moisture and contamination.
• Keep Out of Reach of Children: Store in a safe location to prevent accidental ingestion.
• Avoid Refrigeration or Freezing: These conditions may degrade the drug components.

Do not use after the expiration date printed on the pack. Return unused or expired medications to a pharmacy for proper disposal.