PANADOL Sinus Tablets (Caplets)

What is PANADOL Sinus

PANADOL Sinus is a combination over-the-counter (OTC) medication designed to provide relief from symptoms associated with sinus congestion, pressure, and headache caused by colds, flu, or allergies. It is available in caplet form and contains two active ingredients: Paracetamol (also known as acetaminophen) and Pseudoephedrine Hydrochloride.

• Paracetamol: A widely used analgesic and antipyretic that helps reduce fever and relieve mild to moderate pain such as headaches, sinus pain, and sore throat.
• Pseudoephedrine HCl: A nasal decongestant that acts on the blood vessels in the nasal passages to reduce swelling and congestion.

This combination makes PANADOL Sinus particularly effective for relieving sinus pressure, facial pain, nasal congestion, and associated headaches. It does not treat the underlying infection but provides symptomatic relief.

It comes in a pack of 24 caplets (2 blisters of 12 each), designed for short-term use in adults and adolescents above a certain age threshold, typically 12 years and above.

As with any medicine, PANADOL Sinus should be used as directed and not be taken for extended periods without consulting a healthcare provider.

How to use PANADOL Sinus

Using PANADOL Sinus correctly ensures maximum benefit while minimizing the risk of side effects or overdose. This medication is intended for short-term use only and should be taken as per the dosage instructions provided on the label or by your healthcare provider.

• Administration: Taken orally with water. It can be taken with or without food.
• Recommended Age: Typically for adults and children over 12 years. Always check age restrictions on the package or with a healthcare provider.
• Dosage Frequency: 1 to 2 caplets every 4 to 6 hours as needed, not exceeding 8 caplets in 24 hours.
• Duration: Do not use for more than 7 consecutive days without medical advice.

Important usage tips:

• Do not crush or chew the caplets; swallow whole with a full glass of water.
• If a dose is missed, take it as soon as you remember unless it’s close to the next dose. Do not double the dose.
• Avoid using other paracetamol-containing products while taking PANADOL Sinus to prevent accidental overdose.

Consult your doctor if symptoms persist beyond 7 days, worsen, or are accompanied by high fever or rash. Misuse can lead to serious side effects including liver damage from paracetamol overdose or cardiovascular issues from pseudoephedrine misuse.

Mode of Action PANADOL Sinus

PANADOL Sinus acts through a dual mechanism thanks to its combination of two pharmacologically active components: Paracetamol and Pseudoephedrine HCl. Each plays a distinct role in symptom relief.

• Paracetamol:
  • Works by inhibiting the cyclooxygenase (COX) enzyme in the central nervous system (CNS), which in turn decreases the formation of prostaglandins.
  • Prostaglandins are responsible for the pain and fever response, so their suppression results in pain relief and antipyresis.
  • Unlike NSAIDs, paracetamol does not have anti-inflammatory properties and has minimal effects on the peripheral COX enzymes, reducing gastrointestinal side effects.
• Pseudoephedrine HCl:
  • Acts as a sympathomimetic amine and works by stimulating alpha-adrenergic receptors in the nasal mucosa.
  • This stimulation causes vasoconstriction of the blood vessels in the nasal passages, reducing swelling and mucus production.
  • This leads to decreased nasal congestion and improved sinus drainage.

Together, these mechanisms provide targeted relief from sinus-related pain, headache, and nasal congestion, improving breathing and comfort during colds and flu.

PANADOL Sinus Interactions PANADOL Sinus

PANADOL Sinus contains two active ingredients—Paracetamol and Pseudoephedrine—which may interact with other medications, supplements, or health conditions. It's essential to inform your healthcare provider of all medicines you are taking to avoid adverse interactions.

• With other drugs:
  • Monoamine Oxidase Inhibitors (MAOIs): Concurrent use with pseudoephedrine can cause hypertensive crises. Avoid use within 14 days of stopping MAOIs.
  • Beta-blockers and other antihypertensives: Pseudoephedrine may reduce their effectiveness.
  • Warfarin: High-dose or prolonged use of paracetamol may enhance anticoagulant effects, increasing bleeding risk.
  • Other paracetamol-containing drugs: May lead to hepatotoxicity if taken together.
• With food/alcohol:
  • Alcohol increases the risk of liver damage when taken with paracetamol.
• Medical conditions:
  • Use cautiously in patients with hypertension, cardiovascular disease, diabetes, thyroid disease, or prostatic hypertrophy.

Always check with your doctor or pharmacist before starting or stopping any medications while on PANADOL Sinus.

Dosage of PANADOL Sinus

Proper dosing of PANADOL Sinus is critical for effective relief and safety. Always follow the dosage recommendations provided on the packaging or prescribed by a healthcare professional.

• Adults and Children over 12 years:
  • Take 1 to 2 caplets every 4 to 6 hours as needed.
  • Do not exceed 8 caplets in a 24-hour period.
• Children under 12 years:
  • Not recommended unless directed by a physician.

Important dosage notes:

• Do not exceed the recommended dose to avoid liver toxicity from paracetamol and cardiovascular issues from pseudoephedrine.
• If no improvement in symptoms occurs after 7 days, or if fever persists, seek medical advice.
• Space doses evenly throughout the day and avoid nighttime use if you are sensitive to stimulants.

If you suspect an overdose, seek immediate medical help, especially in cases of nausea, vomiting, confusion, abdominal pain, or rapid heartbeat.

Possible side effects of PANADOL Sinus

Most individuals tolerate PANADOL Sinus well when used as directed. However, like all medications, it can cause side effects, especially if taken in excess or by individuals sensitive to its ingredients.

• Common side effects:
  • Insomnia or restlessness (due to pseudoephedrine)
  • Headache
  • Dry mouth or throat
  • Nausea or mild gastrointestinal discomfort
• Less common but serious side effects:
  • Increased blood pressure or heart palpitations
  • Liver damage (especially from overdose or chronic alcohol use)
  • Allergic reactions like rash, itching, swelling, or difficulty breathing

If any of the serious side effects occur, stop the medication immediately and seek medical attention. Always report unusual symptoms to a healthcare professional promptly.

PANADOL Sinus Contraindications PANADOL Sinus

PANADOL Sinus should not be used in certain conditions where it may pose health risks. Be sure to consult a doctor before use, especially if you have preexisting health conditions.

• Absolute contraindications:
  • Known hypersensitivity to paracetamol, pseudoephedrine, or any of the excipients
  • Severe hypertension or coronary artery disease
  • Concurrent or recent use of MAO inhibitors (within 14 days)
  • Severe liver impairment
• Relative contraindications (Use with caution):
  • Diabetes mellitus
  • Thyroid disorders
  • Prostatic hypertrophy with urinary retention
  • Pregnancy and breastfeeding (consult a physician)

Do not self-medicate if you fall into any of the above categories. Always seek advice from your healthcare provider.

Storage of PANADOL Sinus

Proper storage of PANADOL Sinus ensures that the medication retains its effectiveness and prevents accidental ingestion by children or pets.

• Storage Conditions:
  • Store below 25°C (77°F).
  • Keep in original packaging to protect from moisture and light.
• Keep out of reach of children:
  • This medication should always be stored in a secure place, preferably in a locked cabinet.
• Do not use:
  • Past the expiry date printed on the pack.
  • If the packaging is damaged or the tablets appear discolored.

Unused or expired medications should be disposed of responsibly, following local guidelines or through a pharmacy take-back program.