PANADOL Night Tablets/Film-coated

What is PANADOL Night

Panadol Night is a combination medication designed to provide relief from pain and discomfort while aiding sleep. It contains two active ingredients:

• Paracetamol (500 mg): An analgesic and antipyretic that alleviates pain and reduces fever.
• Diphenhydramine Hydrochloride (25 mg): An antihistamine with sedative properties to help induce sleep.

This formulation is intended for short-term use in adults and children aged 12 years and over to manage:

• Headaches
• Backache
• Rheumatic and muscle pain
• Toothache
• Period pain
• Pain associated with colds and flu that disrupt sleep

It is available in film-coated tablet form and should be taken at bedtime to minimize daytime drowsiness. Panadol Night is not recommended for children under 12 years unless advised by a healthcare professional.

How to use PANADOL Night

For optimal effectiveness and safety, follow these usage instructions:

• Adults and Children Aged 16 Years and Over: Take 2 tablets with water approximately 20 minutes before bedtime. Do not exceed 2 tablets in 24 hours.
• Children Aged 12–15 Years: Take 1 tablet with water approximately 20 minutes before bedtime. Do not exceed 1 tablet in 24 hours.

Important Considerations:

• Do not take more than the recommended dose.
• Avoid combining with other paracetamol-containing products to prevent overdose.
• Do not use for more than 7 consecutive nights without consulting a healthcare provider.
• Not recommended for children under 12 years unless directed by a doctor.
• May cause drowsiness; do not drive or operate machinery after taking.
• Avoid alcohol consumption while using this medication.

Mode of Action PANADOL Night

Panadol Night combines two active ingredients that work synergistically to provide pain relief and promote sleep:

• Paracetamol: Acts centrally in the brain to inhibit the synthesis of prostaglandins, chemicals responsible for pain and fever, thereby reducing discomfort and lowering body temperature.
• Diphenhydramine Hydrochloride: A first-generation antihistamine that crosses the blood-brain barrier to block histamine receptors, leading to sedative effects that help induce sleep.

This combination addresses both the physical pain and the sleep disturbances often associated with conditions like headaches, back pain, and flu symptoms, allowing for a more restful night.

PANADOL Night Interactions PANADOL Night

Be aware of potential drug interactions when using Panadol Night:

• Alcohol: Concurrent use may enhance sedative effects and increase the risk of liver damage due to paracetamol.
• CNS Depressants: Combining with other central nervous system depressants (e.g., sedatives, tranquilizers) may potentiate drowsiness and respiratory depression.
• Antihistamines: Using with other antihistamine-containing products can lead to excessive sedation and anticholinergic side effects.
• Monoamine Oxidase Inhibitors (MAOIs): Use with caution; may intensify anticholinergic effects.
• Tricyclic Antidepressants: Increased risk of anticholinergic side effects such as dry mouth, blurred vision, and urinary retention.
• Warfarin: Chronic use of paracetamol may enhance the anticoagulant effect, increasing bleeding risk; monitor INR levels.

Always consult a healthcare provider before combining Panadol Night with other medications.

Dosage of PANADOL Night

Adhering to the recommended dosage is crucial to ensure safety and effectiveness:

• Adults and Children Aged 16 Years and Over: Take 2 tablets with water 20 minutes before bedtime. Do not exceed 2 tablets in 24 hours.
• Children Aged 12–15 Years: Take 1 tablet with water 20 minutes before bedtime. Do not exceed 1 tablet in 24 hours.

Maximum Daily Dose: Do not exceed 4,000 mg of paracetamol from all sources in a 24-hour period.

Duration of Use: Do not use for more than 7 consecutive nights without consulting a healthcare provider.

If pain persists beyond this period, seek medical advice to rule out underlying conditions.

Possible side effects of PANADOL Night

While Panadol Night is generally well-tolerated, some individuals may experience side effects:

• Common Side Effects:
  • Drowsiness
  • Dizziness
  • Dry mouth
  • Headache
• Less Common Side Effects:
  • Blurred vision
  • Difficulty concentrating
  • Gastrointestinal disturbances (e.g., nausea, constipation)
• Rare but Serious Side Effects:
  • Allergic reactions (e.g., rash, itching, swelling)
  • Severe drowsiness or confusion
  • Breathing difficulties
  • Unusual bruising or bleeding

If any serious side effects occur, discontinue use and seek immediate medical attention.

PANADOL Night Contraindications PANADOL Night

Panadol Night should not be used in the following situations:

• Hypersensitivity: Known allergy to paracetamol, diphenhydramine, or any other component of the product.
• Liver Disease: Severe hepatic impairment or active liver disease.
• Renal Disease: Severe renal impairment.
• Respiratory Conditions: Conditions like asthma or chronic obstructive pulmonary disease (COPD) where respiratory depression is a concern.
• Glaucoma: Narrow-angle glaucoma.
• Prostatic Hypertrophy: Benign prostatic hyperplasia with urinary retention.
• Children Under 12 Years: Not recommended unless advised by a healthcare professional.
• Pregnancy and Breastfeeding: Should not be used during pregnancy or lactation unless directed by a healthcare provider.

Consult a healthcare provider before use if you have any underlying health conditions or are taking other medications.

Storage of PANADOL Night

Proper storage ensures the medication remains effective and safe to use:

• Temperature: Store below 25°C in a dry place.
• Packaging: Keep in the original packaging to protect from moisture and light.
• Child Safety: Keep out of reach and sight of children to prevent accidental ingestion.
• Expiration: Do not use after the expiration date printed on the packaging.

If you have any unused or expired medication, consult a pharmacist for proper disposal methods.