PANADOL COLD & FLU NIGHT RELIEF PE Tablets (Caplets)

What is PANADOL COLD & FLU NIGHT RELIEF PE

Panadol Cold & Flu Night Relief PE is an over-the-counter medication formulated to provide nighttime relief from multiple cold and flu symptoms. It combines three active ingredients:

• Paracetamol (500 mg): A pain reliever and fever reducer.
• Phenylephrine Hydrochloride (5 mg): A nasal decongestant.
• Chlorphenamine Maleate (2 mg): An antihistamine to relieve allergy symptoms.

This medicine is intended to alleviate symptoms such as headache, fever, body aches, nasal congestion, sneezing, runny nose, and sore throat—especially at night when such symptoms can disrupt sleep. It is typically presented in a pack of 24 caplets (2 blister strips of 12 each).

Panadol Cold & Flu Night Relief PE is widely trusted for temporary relief and is commonly used during cold and flu seasons. However, it should not be taken continuously for more than 7 days unless under medical supervision. Because it contains multiple active ingredients, caution is advised when taking it with other medications to avoid duplication or interactions.

How to use PANADOL COLD & FLU NIGHT RELIEF PE

Correct use of Panadol Cold & Flu Night Relief PE ensures both safety and effectiveness. Here are the standard usage guidelines:

• Adults and children over 12 years: Take 1–2 caplets every 4–6 hours at night as needed.
• Maximum dose: Do not exceed 8 caplets in 24 hours.
• Duration of use: Do not take for more than 7 consecutive days without medical advice.

Swallow the caplets whole with water. Do not chew, crush, or dissolve them. This medicine is formulated for nighttime use due to the sedative effects of chlorphenamine.

Important Considerations

• Avoid alcohol while using this medication due to enhanced drowsiness and liver toxicity risk.
• Do not take with other medications containing paracetamol.
• Consult a doctor if symptoms persist beyond 7 days or worsen.

Always read the label and package insert before use. If unsure about dosage or compatibility with other medications, seek guidance from a healthcare professional.

Mode of Action PANADOL COLD & FLU NIGHT RELIEF PE

This combination drug works through the synergistic action of its three components:

• Paracetamol: Acts as an analgesic and antipyretic by inhibiting prostaglandin synthesis in the central nervous system. It reduces fever and alleviates mild to moderate pain.
• Phenylephrine: A sympathomimetic that stimulates alpha-adrenergic receptors, causing vasoconstriction of blood vessels in the nasal passages, thereby reducing nasal congestion.
• Chlorphenamine: An H1 receptor antagonist (antihistamine) that relieves sneezing, watery eyes, and runny nose. It also has mild sedative properties, promoting better sleep during illness.

The combination targets both upper respiratory congestion and systemic symptoms of cold and flu. The nighttime formulation helps ensure that symptoms are suppressed while the patient rests and recovers.

PANADOL COLD & FLU NIGHT RELIEF PE Interactions PANADOL COLD & FLU NIGHT RELIEF PE

Before using this medication, inform your healthcare provider of all current medications. Key interactions include:

Paracetamol

• Alcohol: Increases risk of liver toxicity.
• Warfarin: High doses may enhance anticoagulant effect.
• Enzyme-inducing drugs (e.g., rifampicin): May elevate hepatotoxic risk.

Phenylephrine

• MAO Inhibitors: Can cause a hypertensive crisis if taken within 14 days.
• Beta-blockers or tricyclic antidepressants: May enhance cardiovascular side effects.

Chlorphenamine

• Alcohol or sedatives: Additive CNS depression and sedation.
• Anticholinergics: May worsen dry mouth, blurred vision, or urinary retention.

Do not combine this product with other cold and flu remedies unless directed by a healthcare provider.

Dosage of PANADOL COLD & FLU NIGHT RELIEF PE

Adhering to the recommended dosage is essential for safety and efficacy:

• Adults and children aged 12 and over: Take 1–2 caplets every 4 to 6 hours as needed.
• Do not exceed: 8 caplets within 24 hours.
• Course duration: Maximum of 7 days unless advised otherwise by a physician.

Caplets should be taken whole with water. They are intended for nighttime use due to their sedating effects. Elderly patients or those with chronic illnesses should consult a healthcare provider before use.

Never take more than the recommended dose, as paracetamol overdose can cause serious liver damage. In case of accidental overdose, seek immediate medical attention.

Possible side effects of PANADOL COLD & FLU NIGHT RELIEF PE

Common Side Effects

• Drowsiness or sedation (from chlorphenamine)
• Dry mouth or throat
• Constipation or stomach upset
• Dizziness or lightheadedness

Less Common but Serious Side Effects

• Allergic reactions: rash, swelling, or breathing difficulty
• Liver damage with high doses or alcohol use (paracetamol)
• Elevated blood pressure or palpitations (phenylephrine)
• Urinary retention, especially in males with prostate issues

Discontinue use and consult a doctor if any severe reactions occur. Report side effects to your local health authority or pharmacist.

PANADOL COLD & FLU NIGHT RELIEF PE Contraindications PANADOL COLD & FLU NIGHT RELIEF PE

Do not take this medicine if you have any of the following conditions:

• Allergy to paracetamol, phenylephrine, or chlorphenamine
• High blood pressure or severe cardiovascular disease
• Thyroid disorders or diabetes (use with caution)
• Prostate enlargement or urinary retention
• Severe liver or kidney disease
• Recent use of MAO inhibitors (within 14 days)
• Children under 12 years of age

Use with caution in pregnant or breastfeeding women—consult a healthcare provider before use. Always inform your doctor about any pre-existing conditions.

Storage of PANADOL COLD & FLU NIGHT RELIEF PE

p>To maintain the quality and efficacy of the medicine, follow these storage guidelines:

• Temperature: Store below 30°C (86°F).
• Packaging: Keep in original blister packaging to protect from moisture and light.
• Keep out of reach of children: Accidental ingestion can be dangerous.
• Do not use: After the expiration date on the pack.

Do not store in bathrooms or near heat sources. Dispose of any expired or unused medicine responsibly, preferably through a pharmacy take-back program.