OXIRA 8mg Tablets/Film-coated

What is OXIRA 8mg

OXIRA 8mg is a prescription medication that contains Lornoxicam, a non-steroidal anti-inflammatory drug (NSAID) from the oxicam class. It is primarily used for the treatment of acute and chronic pain and inflammation related to musculoskeletal disorders such as osteoarthritis, rheumatoid arthritis, and postoperative pain.

• Active Ingredient: Lornoxicam (8mg per tablet)
• Drug Class: NSAID (Oxicam group)
• Form: Film-coated tablet
• Packaging: 20 tablets (10s Blister x 2)

OXIRA 8mg works by reducing substances in the body that cause inflammation, pain, and fever. It offers both analgesic and anti-inflammatory properties, making it suitable for short-term pain relief and long-term management of inflammatory conditions.

How to use OXIRA 8mg

OXIRA 8mg should be used strictly under medical supervision. The dosage and frequency depend on the medical condition being treated, the severity of symptoms, and patient-specific factors such as age, liver/kidney function, and concurrent medications.

• Oral Administration: Take the tablet with water, preferably after food to reduce gastrointestinal discomfort.
• Dosage Frequency: Typically once or twice daily, as prescribed by a healthcare provider.
• Do Not Crush: Swallow the tablet whole; do not crush, chew, or break it.
• Consistency: Take the medication at the same time each day to maintain even levels in the bloodstream.
• Missed Dose: If a dose is missed, take it as soon as you remember. If it’s near the time for the next dose, skip the missed dose. Do not double the dose.

Patients should avoid alcohol and other NSAIDs while on OXIRA, as these may increase the risk of gastrointestinal bleeding or liver toxicity. Always follow the doctor’s instructions carefully and report any side effects promptly.

Mode of Action OXIRA 8mg

Lornoxicam, the active ingredient in OXIRA 8mg, exerts its effects through the inhibition of prostaglandin synthesis.

• COX Inhibition: Lornoxicam inhibits both COX-1 and COX-2 enzymes, which are responsible for the conversion of arachidonic acid into prostaglandins.
• Analgesic Effect: Reduction in prostaglandin levels leads to decreased sensitivity of pain receptors, thus providing pain relief.
• Anti-inflammatory Action: Prostaglandins play a role in the inflammatory response. By suppressing their production, Lornoxicam reduces redness, swelling, and heat at the affected site.
• Onset and Duration: OXIRA provides relatively quick symptom relief with a half-life of approximately 4 hours, making it effective for both acute and chronic use.

This dual inhibition mechanism ensures effective pain and inflammation control, although it may carry a slightly higher risk of gastrointestinal and renal side effects compared to selective COX-2 inhibitors.

OXIRA 8mg Interactions OXIRA 8mg

OXIRA 8mg (Lornoxicam) can interact with various medications, potentially altering their effects or increasing the risk of side effects.

• Anticoagulants (e.g., Warfarin): Increased risk of bleeding due to synergistic effects on platelet function.
• ACE inhibitors & ARBs: May reduce antihypertensive effects and increase the risk of renal impairment.
• Diuretics: Combined use may decrease diuretic efficiency and elevate renal risk.
• SSRIs & SNRIs: Increased risk of gastrointestinal bleeding.
• Methotrexate: Lornoxicam may increase serum levels and toxicity of methotrexate.
• Cyclosporine: Concurrent use may potentiate nephrotoxicity.
• Other NSAIDs or Corticosteroids: Should be avoided due to cumulative gastrointestinal and renal side effects.

Patients should inform their doctor of all prescription drugs, OTC medications, and herbal supplements they are taking before starting OXIRA 8mg.

Dosage of OXIRA 8mg

The appropriate dosage of OXIRA 8mg depends on the patient's specific condition and response to treatment. Below are typical dosing guidelines:

• Adults (General Pain/Inflammation): 8 mg to 16 mg daily, divided into 1-2 doses.
• Acute Pain Episodes: An initial 8 mg dose can be administered, followed by another 8 mg after 12 hours if needed.
• Maximum Daily Dose: Should not exceed 16 mg per day.
• Long-term Use: Consider lower maintenance doses for chronic conditions to minimize side effects.

OXIRA should be taken after meals to reduce gastrointestinal irritation. Elderly patients or those with liver/kidney issues may require dose adjustments. Do not exceed the prescribed dose without medical supervision.

Possible side effects of OXIRA 8mg

Like other NSAIDs, OXIRA 8mg can cause side effects, although not everyone experiences them. The risk increases with prolonged use or higher doses.

• Common Side Effects:
  • Abdominal pain
  • Nausea and vomiting
  • Indigestion or heartburn
  • Dizziness or headache
• Less Common but Serious Side Effects:
  • Gastrointestinal bleeding or ulcers
  • Liver enzyme elevation or hepatitis
  • Kidney function impairment
  • Allergic reactions such as rash, itching, or swelling
  • Hypertension or edema
• Rare Side Effects:
  • Hematologic changes (e.g., leukopenia)
  • Visual disturbances
  • Tinnitus (ringing in the ears)

Seek immediate medical attention if you notice signs of gastrointestinal bleeding (black/tarry stools), allergic reactions (hives, swelling), or breathing difficulties.

OXIRA 8mg Contraindications OXIRA 8mg

OXIRA 8mg should not be used in certain medical conditions due to the risk of severe adverse effects.

• Known Allergy: Hypersensitivity to Lornoxicam, other oxicams, or any excipient in the formulation.
• Peptic Ulcer or GI Bleeding: History of recurrent ulcers or active gastrointestinal bleeding.
• Severe Liver or Renal Impairment: Risk of drug accumulation and toxicity.
• Uncontrolled Heart Failure: NSAIDs may worsen fluid retention and elevate blood pressure.
• Pregnancy (Especially 3rd Trimester): May harm fetal cardiovascular function (e.g., premature closure of ductus arteriosus).
• Bleeding Disorders: Increased risk of bleeding due to platelet function inhibition.

Always consult a healthcare provider before initiating therapy, particularly in patients with a complex medical history or those on multiple medications.

Storage of OXIRA 8mg

Proper storage ensures the medication remains effective and safe to use throughout its shelf life.

• Temperature: Store at room temperature, between 20°C and 25°C (68°F–77°F).
• Humidity: Keep in a dry place, away from moisture and humidity sources such as bathrooms.
• Light Protection: Store in the original blister packaging to protect from direct sunlight and light exposure.
• Keep Away from Children: Store out of reach and sight of children to avoid accidental ingestion.
• Disposal: Do not flush unused tablets down the toilet. Dispose of them via a medication take-back program or as advised by a pharmacist.

Improper storage can degrade the active compound, reducing efficacy or increasing the risk of adverse effects. Always check the expiry date before use.