LIPOCOMB 10mg/10mg Capsules (Hard Gelatin)

What is LIPOCOMB 10mg/10mg

LIPOCOMB 10mg/10mg is a fixed-dose combination capsule containing two lipid-lowering agents: Rosuvastatin zinc, a statin, and Ezetimibe, a cholesterol absorption inhibitor. This medication is designed to target cholesterol reduction from both endogenous (produced in the liver) and exogenous (dietary) sources, offering a dual mechanism to significantly lower low-density lipoprotein cholesterol (LDL-C). LIPOCOMB is commonly prescribed for patients with primary hypercholesterolemia or mixed dyslipidemia who require additional LDL-C lowering beyond statin monotherapy.

• Class: Statin (Rosuvastatin) + Cholesterol absorption inhibitor (Ezetimibe)
• Main Use: Reduces elevated LDL cholesterol and total cholesterol
• Indicated For: Patients at high cardiovascular risk or those who require combination therapy for lipid control
• Brand Strength: Convenient single-capsule combination

How to use LIPOCOMB 10mg/10mg

Take LIPOCOMB 10mg/10mg exactly as directed by your doctor. This medication is typically taken once a day.

• Take one capsule daily, at the same time each day
• Can be taken with or without food
• Swallow the capsule whole with water
• Do not chew, crush, or open the capsule
• Adhere to a low-cholesterol, low-fat diet during therapy

Mode of Action LIPOCOMB 10mg/10mg

LIPOCOMB provides a synergistic cholesterol-lowering effect through two mechanisms:

• Rosuvastatin: Inhibits HMG-CoA reductase in the liver, reducing endogenous cholesterol production and increasing LDL receptor activity to clear LDL from the blood.
• Ezetimibe: Inhibits cholesterol absorption at the brush border of the small intestine, reducing the amount of cholesterol delivered to the liver.
• Combined, these agents significantly lower circulating LDL-C and improve lipid profiles more effectively than either agent alone.

LIPOCOMB 10mg/10mg Interactions LIPOCOMB 10mg/10mg

LIPOCOMB may interact with other drugs, affecting its safety and efficacy.

• Cyclosporine: May increase blood levels of both components; use with caution
• Antacids: May reduce rosuvastatin absorption; administer at least 2 hours after LIPOCOMB
• Warfarin: May enhance anticoagulant effect; monitor INR closely
• Gemfibrozil or other fibrates: Increases risk of muscle toxicity
• Cholestyramine: Reduces ezetimibe absorption; dose apart

Dosage of LIPOCOMB 10mg/10mg

• Typical adult dose: One capsule (10mg rosuvastatin / 10mg ezetimibe) daily
• Not recommended for patients with active liver disease or significant hepatic impairment
• Patients with renal impairment should be assessed for dose adjustment
• Regular monitoring of lipid profile and liver function is advised during treatment

Possible side effects of LIPOCOMB 10mg/10mg

LIPOCOMB is generally well tolerated, but side effects may occur:

• Common: Headache, abdominal pain, muscle pain, fatigue
• Less Common: Nausea, diarrhea, elevated liver enzymes
• Serious (Rare): Myopathy, rhabdomyolysis, liver dysfunction, hypersensitivity reactions
• Seek immediate medical attention for symptoms like muscle weakness, dark urine, or jaundice

LIPOCOMB 10mg/10mg Contraindications LIPOCOMB 10mg/10mg

• Known hypersensitivity to rosuvastatin, ezetimibe, or any excipients
• Active liver disease or unexplained persistent elevations of liver transaminases
• Pregnancy and lactation (statins are contraindicated due to teratogenicity)
• Severe renal impairment without medical supervision

Storage of LIPOCOMB 10mg/10mg

• Store at room temperature (15°C–30°C)
• Keep in original packaging, away from moisture and light
• Do not store in bathroom or freezer
• Keep out of reach of children
• Do not use after the expiration date printed on the pack