LEVOMAC 500 Tablets/Film-coated

What is LEVOMAC 500

LEVOMAC 500 is a prescription antibiotic medicine that contains Levofloxacin as its active ingredient. It belongs to the fluoroquinolone class of antibiotics, known for their broad-spectrum antibacterial activity. LEVOMAC 500 is formulated as film-coated tablets and is available in a 5’s blister pack, making it suitable for short-course therapies in outpatient or hospital settings.

Key highlights:

• Generic Name: Levofloxacin
• Form: Film-coated tablet
• Strength: 500mg
• Primary Use: Treatment of respiratory infections, urinary tract infections, gastrointestinal infections, skin infections, and some sexually transmitted infections.
• Mode: Works by directly killing bacteria, stopping infection progression quickly and effectively.

How to use LEVOMAC 500

Correct usage of LEVOMAC 500 ensures effective eradication of infection and minimizes the risk of bacterial resistance. Always follow your healthcare provider’s instructions precisely when using this medicine.

Usage instructions:

• Take one 500mg tablet by mouth, usually once daily unless otherwise directed.
• Swallow the tablet whole with plenty of water; do not crush, chew, or break it.
• It can be taken with or without food. If stomach upset occurs, taking it with food may help.
• If you are also using antacids, iron, or zinc supplements, take LEVOMAC 2 hours before or after these products to avoid absorption issues.
• Complete the full prescribed course, even if symptoms resolve early, to prevent recurrence or antibiotic resistance.
• If you miss a dose, take it as soon as you remember. If it’s almost time for the next dose, skip the missed one. Never double dose to catch up.

Mode of Action LEVOMAC 500

LEVOMAC 500 works by directly interfering with bacterial DNA processes, resulting in the death of the bacteria and resolution of the infection.

Mechanism of action:

• Inhibits bacterial enzymes called DNA gyrase and topoisomerase IV.
• DNA gyrase is crucial for supercoiling DNA, a necessary process for replication and transcription.
• Topoisomerase IV plays a key role during bacterial cell division by separating replicated DNA.
• Inhibition of these enzymes leads to DNA damage, preventing bacteria from multiplying and causing bacterial cell death.
• This bactericidal activity makes LEVOMAC highly effective against a broad range of Gram-positive and Gram-negative bacteria.

LEVOMAC 500 Interactions LEVOMAC 500

LEVOMAC 500 can interact with other medications, potentially altering its effects or increasing side effects. It's crucial to inform your doctor about all the medicines and supplements you are taking.

Common interactions include:

• Antacids containing magnesium or aluminum: Reduce absorption of Levofloxacin; take separately by at least 2 hours.
• Iron supplements and multivitamins: Can also impair absorption; maintain a safe gap.
• Warfarin: May increase the risk of bleeding; regular monitoring of INR is recommended.
• NSAIDs (e.g., ibuprofen): Can enhance the risk of central nervous system stimulation, such as seizures.
• Antidiabetic drugs: Risk of blood sugar fluctuations; careful glucose monitoring is necessary.

Dosage of LEVOMAC 500

The dosage of LEVOMAC 500 depends on the infection being treated, the patient’s age, weight, kidney function, and severity of the infection. Always follow the prescribed dosage without modifications.

Typical dosage guidelines:

• Acute sinusitis: 500mg once daily for 10–14 days.
• Community-acquired pneumonia: 500mg once daily for 7–14 days.
• Urinary tract infections (complicated): 500mg once daily for 7–14 days.
• Skin and soft tissue infections: 500mg once or twice daily for 7–14 days depending on severity.
• Kidney impairment: Dose adjustment is necessary based on creatinine clearance (renal function tests must be evaluated before prescribing).

Possible side effects of LEVOMAC 500

While LEVOMAC 500 is generally well-tolerated, some individuals may experience side effects ranging from mild to serious. Immediate medical consultation is advised if severe reactions occur.

Common side effects:

• Nausea, diarrhea, and vomiting
• Headache, dizziness, or lightheadedness
• Insomnia or sleep disturbances
• Constipation or abdominal pain

Serious side effects (seek urgent medical help):

• Tendon rupture or tendinitis, especially in the elderly
• Peripheral neuropathy (numbness, tingling)
• Seizures or convulsions
• Severe allergic reactions (rash, swelling, difficulty breathing)
• Psychiatric symptoms (hallucinations, confusion, depression)

LEVOMAC 500 Contraindications LEVOMAC 500

LEVOMAC 500 is contraindicated in specific patient groups where risks far outweigh potential benefits. Careful patient history assessment is essential before prescribing.

Contraindications include:

• Known hypersensitivity to Levofloxacin or other quinolones
• Patients with a history of tendon disorders associated with quinolone use
• Children and adolescents (<18 years old) due to the risk of musculoskeletal disorders
• Pregnancy and breastfeeding unless the benefits clearly outweigh risks
• Patients with epilepsy or those predisposed to seizures
• Severe renal impairment without appropriate dosage adjustment

Storage of LEVOMAC 500

Proper storage of LEVOMAC 500 helps preserve its effectiveness and ensures patient safety during its shelf life.

Storage recommendations:

• Store at controlled room temperature between 15°C and 30°C (59°F–86°F).
• Keep the medicine in its original packaging to protect it from moisture and light.
• Do not store in the bathroom or other humid areas.
• Keep out of the reach of children and pets.
• Do not use after the expiry date stated on the packaging. Dispose of expired tablets safely as per pharmacy or local disposal guidelines.